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Emerging Microbes & Infections Volume 8, 2019 - Issue 1
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Original Articles

Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection

Ying Yana State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Lena Allweissb Department of Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyView further author information
,
Danli Yanga State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Jingting Kangc Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, People’s Republic of ChinaView further author information
,
Jianwen Wanga State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Xiangjun Qiana State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Ting Zhanga State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Hui Liua State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Lu Wanga State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Shuhong Liud Department of Pathology and Hepatology, The 5th Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaView further author information
,
Jianhua Suie Biologics Research Center, National Institute of Biological Sciences, Beijing, People’s Republic of ChinaView further author information
,
Xiangmei Chena State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Maura Dandrib Department of Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;f German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Partner Site, Hamburg, GermanyCorrespondence[email protected]
View further author information
,
Jingmin Zhaod Department of Pathology and Hepatology, The 5th Medical Centre, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Fengmin Lua State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1832-3209View further author information
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Pages 879-894 | Received 06 Feb 2019, Accepted 26 Apr 2019, Published online: 09 Jun 2019

Related Research Data

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients
Source: American Society for Pharmacology & Experimental Therapeutics (ASPET)
Hepatocyte turnover during resolution of a transient hepadnaviral infection
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The Role of cccDNA in HBV Maintenance
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Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D Virus In Vivo.
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Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma.
Source: The Korean Association for the Study of the Liver
Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
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Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters
Source: Springer Science and Business Media LLC
Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver
Source: Elsevier BV
A dileucine motif is involved in plasma membrane expression and endocytosis of rat sodium taurocholate cotransporting polypeptide (Ntcp)
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Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
Source: HAL CCSD
Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infections.
Source: American Society for Microbiology
Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.
Source: American Society for Clinical Investigation
Down-regulation of cell membrane localized NTCP expression in proliferating hepatocytes prevents hepatitis B virus infection
Source: Taylor & Francis
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Hepatocyte turnover in transient and chronic hepadnavirus infections
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Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection
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