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Emerging Microbes & Infections Volume 8, 2019 - Issue 1
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Original Articles

Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription

Jingliang Chena Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Zhangping Hea Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Yaochang Yuana Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Feng Huanga Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of China;b Department of Respiration, Affiliated Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Baohong Luoa Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaView further author information
,
Jianhua Zhangc CAS Key Laboratory for Pathogenic Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaView further author information
,
Ting Pana Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
Hui Zhanga Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Junsong Zhanga Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1347-1360 | Received 14 Mar 2019, Accepted 22 Jul 2019, Published online: 13 Sep 2019

Related Research Data

Role of Ebola Virus VP30 in Transcription Reinitiation
Source: American Society for Microbiology
Sequence analysis of the Ebola virus genome: organization, genetic elements, and comparison with the genome of Marburg virus.
Source: Elsevier BV
Dynamic Phosphorylation of VP30 is essential for Ebola virus life cycle
Source: American Society for Microbiology
Assembly and Budding of Ebolavirus
Source: Public Library of Science (PLoS)
The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis.
Source: Public Library of Science (PLoS)
Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells
Source: Oxford University Press (OUP)
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
Source: HAL CCSD
A Novel Life Cycle Modeling System for Ebola Virus Shows a Genome Length-Dependent Role of VP24 in Virus Infectivity
Source: American Society for Microbiology
Phosphorylation of Ebola virus VP30 influences the composition of the viral nucleocapsid complex: impact on viral transcription and replication.
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Ebola virus VP35 blocks stress granule assembly.
Source: Elsevier BV
Role of Protein Phosphatase 1 in Dephosphorylation of Ebola Virus VP30 Protein and Its Targeting for the Inhibition of Viral Transcription
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Oligomerization of Ebola Virus VP40 Is Essential for Particle Morphogenesis and Regulation of Viral Transcription
Source: American Society for Microbiology
The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells
Source: Nature Publishing
Reporter assays for Ebola virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111
Source: Cold Spring Harbor Laboratory
Characterization of the Ebola virus nucleoprotein-RNA complex.
Source: Microbiology Society
Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcription.
Source: Elsevier BV
Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding
Source: Oxford University Press (OUP)
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Source: Wiley
Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication
Source: Public Library of Science (PLoS)
Inclusion Bodies Are a Site of Ebolavirus Replication
Source: American Society for Microbiology
DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
Source: American Society for Microbiology

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