Advanced search
Publication Cover
Emerging Microbes & Infections Volume 8, 2019 - Issue 1
Submit an article Journal homepage
2,409
Views
28
CrossRef citations to date
0
Altmetric
Original Articles

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

Xin Houa Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;b Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;c Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, People’s Republic of China;d Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USAView further author information
,
Kelley R. Healeye Department of Biology, William Paterson University, Wayne, NJ, USAView further author information
,
Erika Shord Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USAView further author information
,
Milena Kordalewskad Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USAView further author information
,
Cristina Jiménez Ortigosad Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USAView further author information
,
Padmaja Paderud Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USAView further author information
,
Meng Xiaoa Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;c Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, People’s Republic of ChinaView further author information
,
He Wanga Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;c Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, People’s Republic of ChinaView further author information
,
Ying Zhaoa Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;c Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, People’s Republic of ChinaView further author information
,
Li-Yan Linf School of Medicine, Peking University Health Science Center, Beijing, People’s Republic of ChinaView further author information
,
Yan-Hai Zhangg Central Laboratory, Hebei Yanda Hospital, Langfang, People’s Republic of ChinaView further author information
,
Yong-Zhe Lia Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;b Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of ChinaView further author information
,
Ying-Chun Xua Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;b Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China;c Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
,
David S. Perlind Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USAView further author information
&
Yanan Zhaod Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA;h Department of Medical Sciences, Hackensack Meridian School of Medicine at Seton Hall University, Nutley, NJ, USACorrespondence[email protected]
View further author information
 show all
Pages 1619-1625 | Received 26 Aug 2019, Accepted 17 Oct 2019, Published online: 12 Nov 2019

Related Research Data

Global trends in the distribution of Candida species causing candidemia
Source: European Society of Clinical Infectious Diseases. Published by Elsevier Ltd.
Mechanism of echinocandin drug resistance
Source: Wiley
Use of RNA-Protein Complexes for Genome Editing in Non-albicans Candida Species
Source: American Society for Microbiology
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Source: American Society for Microbiology
Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant Candida tropicalis and Candida glabrata isolates with delineation of their resistance mechanisms
Source: Informa UK Limited
Follow-Up to a Randomized Clinical Trial
Source: Ovid Technologies (Wolters Kluwer Health)
Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin
Source: Amer Soc Microbiology
Role of FKS Mutations in Candida glabrata: MIC Values, Echinocandin Resistance, and Multidrug Resistance
Source: American Society for Microbiology
ANALYSIS OF RELATIVE GENE EXPRESSION DATA USING REAL-TIME QUANTITATIVE PCR AND THE 2(-DELTA DELTA C(T)) METHOD
Source: Elsevier BV
Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression
Source: Oxford University Press (OUP)
How to calculate sample size in animal studies
Source: Medknow
Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of their disruptant strains by sequential integrative transformation.
Source: Elsevier BV
Specific Substitutions in the Echinocandin Target Fks1p Account for Reduced Susceptibility of Rare Laboratory and Clinical Candida sp. Isolates
Source: American Society for Microbiology
Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
Source: Oxford University Press (OUP)
Candida glabrata Intra-Abdominal Candidiasis Is Characterized by Persistence within the Peritoneal Cavity and Abscesses
Source: American Society for Microbiology

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.