Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D²EFT

Emmanuelle Papot1 Therapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, AustraliaCorrespondence[email protected]

https://orcid.org/0000-0003-2782-0263 View further author information

Simone Jacoby1 Therapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, AustraliaView further author information

Dona Arlinda2 Indonesia Research Partnership on Infectious Disease, Jakarta, IndonesiaView further author information

Anchalee Avihingsanon3 The HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, ThailandView further author information

Iskandar Azwa4 Infectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaView further author information

Margaret Borok5 University of Zimbabwe Clinical Research Centre, Harare, ZimbabweView further author information

Dannae Brown6 Global Medical, ViiV Healthcare, Abbotsford, AustraliaView further author information

Mohamed Cissé7 Faculté des Sciences et techniques de la santé de l’Université Gamal Abdel Nasser de Conakry, University hospital of Donka, Conakry, Guinea

https://orcid.org/0000-0002-6859-8745 View further author information

Sounkalo Dao8 University Clinical Research Centre, Bamako, MaliView further author information

Nnakelu Eriobu9 Institute of Human Virology, Abuja, NigeriaView further author information

Richard Kaplan10 Desmond Tutu Health Foundation, Cape Town, South AfricaView further author information

Muhammad Karyana2 Indonesia Research Partnership on Infectious Disease, Jakarta, IndonesiaView further author information

Nagalingeswaran Kumarasamy11 Chennai Antiviral Research and Treatment Clinical Research Site, Infectious Diseases Medical Centre, Voluntary Health Services, Chennai, IndiaView further author information

Johnnie Lee12 Global Medical Affairs, Global Public Health, Janssen Pharmaceutical companies of Johnson & Johnson, Plainfield, NJ, USAView further author information

Marcelo H. Losso13 Coordinación en Investigación Clínica Académica en Latinoamérica Fundación IBIS Buenos Aires, Buenos Aires, ArgentinaView further author information

Gail V. Matthews1 Therapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, AustraliaView further author information

Leonardo Perelis13 Coordinación en Investigación Clínica Académica en Latinoamérica Fundación IBIS Buenos Aires, Buenos Aires, ArgentinaView further author information

Carmen Perez-Casas14 Unitaid, Geneva, SwitzerlandView further author information

Kiat Ruxrungtham3 The HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, ThailandView further author information

Melynda Watkins15 Product Development and Regulatory Affairs, Clinton Health Access Initiative, Boston, MA, USAView further author information

H. Clifford Lane16 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USAView further author information

Anthony Kelleher17 Immunovirology and Pathogenesis Program, The Kirby Institute, University of New South Wales Sydney, Sydney,AustraliaView further author information

Matthew Law18 Biostatistics and Databases Program, The Kirby Institute, University of New South Wales Sydney, Sydney,AustraliaView further author information

Mark N. Polizzotto1 Therapeutic and Vaccine Research Program, The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia;19 Department of Haematology, The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, Australia

https://orcid.org/0000-0002-6446-183X View further author information

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Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D²EFT

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Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D²EFT