The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4⁺ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

Azlann Arnetta Benaroya Research Institute, Seattle, Washington, USA

Keagan G. Mooa Benaroya Research Institute, Seattle, Washington, USA

Kaitlin J. Flynna Benaroya Research Institute, Seattle, Washington, USA

Thomas B. Sundbergb Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA

Liv Johannessenc Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

Alykhan F. Shamjib Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA

Nathanael S. Grayc Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

Thomas Deckerd Max Perutz Labs, University of Vienna, Vienna, Austria

Ye Zhenge NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA

Vivian H. Gersuka Benaroya Research Institute, Seattle, Washington, USA

Ziaur S. Rahmanf Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

David E. Levyg Department of Pathology, New York University School of Medicine, New York, New York, USA

Isabelle J. Mariég Department of Pathology, New York University School of Medicine, New York, New York, USA

Peter S. Linsleya Benaroya Research Institute, Seattle, Washington, USA

Ramnik J. Xavierh Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;i The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA

Bernard Khora Benaroya Research Institute, Seattle, Washington, USACorrespondence[email protected]

https://orcid.org/0000-0003-4689-5092

show all

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4⁺ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

SUPPLEMENTAL FILE 1 Tables S1 and S2. Download TMCB_A_12277284_SM0001.pdf, PDF file, 0.2 MB.

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4+ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

SUPPLEMENTAL FILE 1 Tables S1 and S2. Download TMCB_A_12277284_SM0001.pdf, PDF file, 0.2 MB.

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4⁺ T Cells via a Novel CDK8-GATA3-FOXP3 Pathway