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Epigenomics Volume 14, 2022 - Issue 23
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Research Article

Opioid Medication Use and Blood Dna Methylation: Epigenome-Wide Association Meta-Analysis

Mikyeong Lee1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USAORCID Iconhttps://orcid.org/0000-0002-3036-3684View further author information
ORCID Icon,
Roby Joehanes2 Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA01702, USAORCID Iconhttps://orcid.org/0000-0001-5549-9054View further author information
ORCID Icon,
Daniel L McCartney3 Centre for Genomic & Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UKView further author information
,
Minjung Kho4 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USAView further author information
,
Anke Hüls5 Department of Epidemiology & Gangarosa, Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USAView further author information
,
Annah B Wyss1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USAView further author information
,
Chunyu Liu6 Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02215, USA;7 Framingham Heart Study, Boston University, Framingham, MA 01702, USAView further author information
,
Rosie M Walker8 Centre for Clinical Brain Science, Chancellor’s Building, 49 Little France Crescent, Edinburgh Bioquarter, Edinburgh, UK;9 School of Psychology, University of Exeter, Exeter, UKView further author information
,
Sharon L R Kardia4 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USAView further author information
,
Thomas S Wingo10 Department of Neurology & Human Genetics, Emory University, Atlanta, GA 30322, USAView further author information
,
Adam Burkholder11 Office of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USAView further author information
,
Jiantao Ma2 Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA01702, USAView further author information
,
Archie Campbell3 Centre for Genomic & Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UKView further author information
,
Aliza P Wingo12 Department of Psychiatry & Behavioral Sciences, Emory University, Atlanta, GA 30322, USAView further author information
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Tianxiao Huan2 Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA01702, USA;13 Department of Ophthalmology, University of Massachusetts Medical School, Worcester, MA 01655, USAView further author information
,
Sinjini Sikdar1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA;14 Department of Mathematics & Statistics, Old Dominion University, Norfolk, VA 23529, USAView further author information
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Amena Keshawarz15 Framingham Heart Study, Framingham, MA 01702, USA;16 Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USAView further author information
,
David A Bennett17 Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USAView further author information
,
Jennifer A Smith4 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USAView further author information
,
Kathryn L Evans3 Centre for Genomic & Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UKView further author information
,
Daniel Levy2 Department of Health and Human Services, Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA01702, USAView further author information
&
Stephanie J London1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4911-5290View further author information
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Pages 1479-1492 | Received 07 Oct 2022, Accepted 13 Jan 2023, Published online: 26 Jan 2023

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