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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 8
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General Xenobiochemistry

Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes

Norimasa JinnoLaboratory for Safety Assessment and ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation Mifuku Izunokuni, ShizuokaJapan;Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka Suruga-ku, ShizuokaJapanCorrespondence[email protected]
,
Mizuka TagashiraLaboratory for Safety Assessment and ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation Mifuku Izunokuni, ShizuokaJapan
,
Kazuyuki TsuruiLaboratory for Safety Assessment and ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation Mifuku Izunokuni, ShizuokaJapan
&
Shizuo YamadaDepartment of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka Suruga-ku, ShizuokaJapan
Pages 677-686 | Received 25 Dec 2013, Accepted 10 Feb 2014, Published online: 27 Feb 2014

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