Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. WiklanderDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Joel Z. NordinDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Aisling O'LoughlinDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, United Kingdom

Ylva GustafssonAdvanced Centre for Translational Regenerative MedicineDepartment for Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

Giulia CorsoDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Imre MägerDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, United Kingdom;Institute of TechnologyUniversity of Tartu, Tartu, Estonia

Pieter VaderDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, United Kingdom

Yi LeeDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, United Kingdom

Helena SorkDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Yiqi SeowMolecular Engineering LaboratoryAgency for Science, Technology and Research (A*STAR), Singapore

Nina HeldringDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Lydia Alvarez-ErvitiDepartment of Clinical NeuroscienceInstitute of Neurology, University College London, London, United Kingdom

CI Edvard SmithDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Katarina Le BlancDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden;Haematology CentreKarolinska University Hospital, Stockholm, Sweden

Paolo MacchiariniAdvanced Centre for Translational Regenerative MedicineDepartment for Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

Philipp JungebluthAdvanced Centre for Translational Regenerative MedicineDepartment for Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;Department of Thoracic SurgeryThoraxklinik, Heidelberg University, Heidelberg, Germany

Matthew J. A. WoodDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, United Kingdom

Samir EL AndaloussiDepartment of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden;Department of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, United KingdomCorrespondence[email protected]

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

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