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Future Medicinal Chemistry Volume 6, 2014 - Issue 18
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Research Article

Practical Permeability-Based Hepatic Clearance Classification System (Hepccs) in Drug Discovery

Peter W Fan1 Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA94080, USACorrespondence[email protected]
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,
Yang Song2 Department of Analytical Chemistry & DMPK, ChemoCentryx, Inc., 850 W Maude Ave, Mountain View, CA94043, USAView further author information
,
Leonid M Berezhkovskiy1 Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA94080, USAView further author information
,
Jonathan Cheong1 Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA94080, USAView further author information
,
Emile G Plise1 Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA94080, USAView further author information
&
S Cyrus Khojasteh1 Department of Drug Metabolism & Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA94080, USAView further author information
Pages 1995-2012 | Published online: 22 Dec 2014
Supplemental material

Appendix: Modeling of plasma and intracellular water concentration in liver for Classes M, T, P, and C drugs.

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