Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Mallika Valapala Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Christine Wilson Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Stacey Hose Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Imran A Bhutto Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Rhonda Grebe Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Aling Dong Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Seth Greenbaum Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Limin Gu Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA; Department of Ophthalmology of Shanghai Tenth People’s Hospital and Tongji Eye Institute; Tongji University School of Medicine; Shanghai, China

Samhita Sengupta Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Marisol Cano Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Sean Hackett Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Guotong Xu Department of Ophthalmology of Shanghai Tenth People’s Hospital and Tongji Eye Institute; Tongji University School of Medicine; Shanghai, China

Gerard A Lutty Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Lijin Dong National Eye Institute; National Institutes of Health; Bethesda, MD USA

Yuri Sergeev National Eye Institute; National Institutes of Health; Bethesda, MD USA

James T Handa Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Peter Campochiaro Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Eric Wawrousek National Eye Institute; National Institutes of Health; Bethesda, MD USA

J Samuel Zigler, Jr Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USA

Debasish Sinha Wilmer Eye Institute; Johns Hopkins University School of Medicine; Baltimore, MD USACorrespondence[email protected]

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Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

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Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

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