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Cancer Biology & Therapy Volume 13, 2012 - Issue 11
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Research Paper

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia

Jayashree Karar Department of Radiation Oncology; Perelman School of Medicine of the University of Pennsylvania; Philadelphia, PA USA
,
George J. Cerniglia Department of Radiation Oncology; Perelman School of Medicine of the University of Pennsylvania; Philadelphia, PA USA
,
Tullia Lindsten Immunology Program; Sloan-Kettering Institute; Memorial Sloan-Kettering Cancer Center; New York, NY USA
,
Constantinos Koumenis Department of Radiation Oncology; Perelman School of Medicine of the University of Pennsylvania; Philadelphia, PA USA
&
Amit Maity Department of Radiation Oncology; Perelman School of Medicine of the University of Pennsylvania; Philadelphia, PA USACorrespondence[email protected]
Pages 1102-1111 | Received 18 May 2012, Accepted 17 Jun 2012, Published online: 16 Aug 2012

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Related Research Data

Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome
Source: MDPI AG

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