Supplemental material
Cell Cycle
Volume 11, 2012 - Issue 12
Related Research Data
Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers.
Source:
Informa UK Limited
A new chronological survival assay in mammalian cell culture.
Source:
Informa UK Limited
Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage
Source:
Informa UK Limited
The molecular scaffold kinase suppressor of Ras 1 is a modifier of Ras V12-induced and replicative senescence
Source:
American Society for Microbiology
Controversial aspects of oncogene-induced senescence.
Source:
Informa UK Limited
Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density.
Source:
Impact Journals, LLC
Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling
Source:
Elsevier BV
EXTENSION OF LIFE-SPAN BY INTRODUCTION OF TELOMERASE INTO NORMAL HUMAN CELLS
Source:
American Association for the Advancement of Science (AAAS)
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α
Source:
Elsevier BV
Rapamycin, proliferation and geroconversion to senescence.
Source:
Informa UK Limited
Hypoxia and gerosuppression: the mTOR saga continues.
Source:
Informa UK Limited
Molecular mechanisms of mTOR-mediated translational control
Source:
Springer Science and Business Media LLC
mTOR signaling in disease
Source:
Elsevier BV
Putting the stress on senescence
Source:
Elsevier BV
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Source:
American Association for the Advancement of Science (AAAS)
Less is more?
Source:
Informa UK Limited
Cellular senescence, cancer and aging: the telomere connection.
Source:
Elsevier BV
Dysregulation of the TSC-mTOR pathway in human disease.
Source:
Springer Science and Business Media LLC
mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
Source:
Elsevier BV
The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.
Source:
Impact Journals, LLC
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
Source:
Cold Spring Harbor Laboratory
Extension of chronological life span in yeast by decreased TOR pathway signaling
Source:
Cold Spring Harbor Laboratory
Ageing, Cellular Senescence and Neurodegenerative Disease.
Source:
MDPI AG
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Source:
American Association for the Advancement of Science (AAAS)
Rapamycin decelerates cellular senescence
Source:
Informa UK Limited
Conserved role of medium acidification in chronological senescence of yeast and mammalian cells
Source:
HAL CCSD
Autophagy is required for extension of yeast chronological life span by rapamycin
Source:
Informa UK Limited
Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.
Source:
Mary Ann Liebert Inc
Mechanisms of cellular senescence in human and mouse cells.
Source:
Springer Science and Business Media LLC
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.
Source:
Informa UK Limited
Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescence Signaling
Source:
American Society for Microbiology
mTORC1 signaling governs hematopoietic stem cell quiescence.
Source:
Informa UK Limited
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
Source:
The Company of Biologists
Upstream and downstream of mTOR
Source:
Cold Spring Harbor Laboratory
Geroconversion: irreversible step to cellular senescence.
Source:
Informa UK Limited
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Source:
Springer Science and Business Media LLC
Hayflick, his limit, and cellular ageing
Source:
Springer Science and Business Media LLC
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Source:
Nature Publishing Group
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.
Source:
American Society for Microbiology
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