Bispecific and Multispecific Antibodies Collection
Antibodies and antibody derived bispecifics are one of the most successful therapeutic classes due to their excellent target specificity and tunable drug-like properties. The ability to tailor antibody functions using modern engineering approaches has ushered in a new wave of bi- and multi-specific antibody therapeutics that unlock novel target classes, biology, and mechanisms of action for the treatment of human diseases. In this collection, we examine the progress in the bispecific antibody landscape over the past decade, emphasizing their design and high-throughput production. Our specific reviews delve into biparatopic and VHH-based bispecific antibodies. Additionally, this collection highlights developability properties, including format, valency, pharmacokinetics, and hydrophobicity. We express our gratitude to the authors for their valuable contributions and anticipate that this compilation will aid readers and scientists worldwide in advancing life-transforming therapies for patients.
Edited by
Dr. Nimish Gera(Mythic Therapeutics)
Dr. Li Zhou(AbbVie)
Dr. Jonathan Sockolosky(Curie.bio)