Drug Delivery, Volume 30, Issue 1 (2023)

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Drug Delivery, Volume 30, Issue 1 (2023)

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Research Article

Article
Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery
Ling-Chun Chen, Shyr-Yi Lin, Wei-Jie Cheng, Ming-Thau Sheu, Chi-Yun Chung, Chen-Hsuan Hsu & Hong-Liang Lin
Article: 2158964
Published online: 01 Jan 2023
AbstractforPoloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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RESEARCH ARTICLE

Article
Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks
Abdul Jabbar, Khadija Rehman, Tooba Jabri, Tasmina Kanwal, Samina Perveen, Md Abdur Rashid, Mohsin Kazi, Saeed Ahmad Khan, Salim Saifullah & Muhammad Raza Shah
Article: 2159587
Published online: 31 Jan 2023
AbstractforImproving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks | Full Text | References | PDF (2.8 MB) | EPUB
  • 3660 Views
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Research Article

Article
Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease
Xian Chen, Wenni Dai, Hao Li, Zhe Yan, Zhiwen Liu & Liyu He
Article: 2160518
Published online: 28 Dec 2022
AbstractforTargeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease | Full Text | References | PDF (1 MB) | EPUB
  • 3746 Views
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Open Access
Article
Progress in the application of hydrogels in immunotherapy of gastrointestinal tumors
Hao Zheng, Meng Li, Lili Wu, Wenshang Liu, Yu Liu, Jie Gao & Zhengmao Lu
Article: 2161670
Published online: 01 Jan 2023
AbstractforProgress in the application of hydrogels in immunotherapy of gastrointestinal tumors | Full Text | References | PDF (1.5 MB) | EPUB
  • 2854 Views
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Open Access

Review

Review
Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application
Xiaoming Zhong, Jianqiong Yang, Hongyan Liu, Zhiwen Yang & Ping Luo
Article: 2161671
Published online: 05 Jan 2023
AbstractforPotential lipid-based strategies of amphotericin B designed for oral administration in clinical application | Full Text | References | PDF (2.8 MB) | EPUB
  • 2774 Views
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Research Article

Article
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery
Simeng Xiao, Siying Huang, Xiaojing Yang, Yujie Lei, Mingxiang Chang, Junjie Hu, Yan Meng, Guohua Zheng & Xinyan Chen
Article: 2162156
Published online: 04 Jan 2023
AbstractforThe development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2676 Views
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Open Access
Article
‘Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity’: in-vitro and insilico studies
Mohamed Y. Zakaria, Shady M. Abd El-Halim, Botros Y. Beshay, Islam Zaki & Mohammed A.S Abourehab
Article: 2162157
Published online: 01 Jan 2023
Abstractfor‘Poly phenolic phytoceutical loaded nano-bilosomes for enhanced caco-2 cell permeability and SARS-CoV 2 antiviral activity’: in-vitro and insilico studies | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1993 Views
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Open Access
Article
Development of phospholipon®90H complex nanocarrier with enhanced oral bioavailability and anti-inflammatory potential of genistein
Vaishnavi S. Shete, Darshan R. Telange, Nilesh M. Mahajan, Anil M. Pethe & Debarshi K. Mahapatra
Article: 2162158
Published online: 01 Jan 2023
AbstractforDevelopment of phospholipon®90H complex nanocarrier with enhanced oral bioavailability and anti-inflammatory potential of genistein | Full Text | References | PDF (2.2 MB) | EPUB
  • 2178 Views
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Open Access
Article
Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment
Heba Amin Elgendy, Amna M. A. Makky, Yara E. Elakkad, Radwa M. Ismail & Nihal Farid Younes
Article: 2162159
Published online: 05 Jan 2023
AbstractforSyringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment | Full Text | References | PDF (3.1 MB) | EPUB
  • 2240 Views
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RESEARCH ARTICLE

Article
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion
Congyi Zhang, Zehui Liu, Feng Wang, Bin Zhang, Xirui Zhang, Peiwen Guo, Tianwei Li, Sheng Tai & Changmei Zhang
Article: 2162160
Published online: 29 Dec 2022
AbstractforNanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion | Full Text | References | PDF (3.2 MB) | EPUB
  • 2248 Views
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Article
The cell type dependent sorting of CD9- and CD81 to extracellular vesicles can be exploited to convey tumor sensitive cargo to target cells
Stefania Zuppone, Natasa Zarovni & Riccardo Vago
Article: 2162161
Published online: 29 Dec 2022
AbstractforThe cell type dependent sorting of CD9- and CD81 to extracellular vesicles can be exploited to convey tumor sensitive cargo to target cells | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2088 Views
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Research Article

Article
Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation
Nabil A. Shoman, Rana M. Gebreel, Mohamed A. El-Nabarawi & Alshaimaa Attia
Article: 2162162
Published online: 01 Jan 2023
AbstractforOptimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation | Full Text | References | PDF (1.5 MB) | EPUB
  • 2432 Views
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Article
In-depth study of anticancer drug diffusion through a cross-linked ­pH-responsive polymeric vesicle membrane
Fen Zhang, Qian Yao, Xiaoqi Chen, Haijun Zhou, Mengmeng Zhou, Yantao Li & Hua Cheng
Article: 2162626
Published online: 04 Jan 2023
AbstractforIn-depth study of anticancer drug diffusion through a cross-linked ­pH-responsive polymeric vesicle membrane | Full Text | References | PDF (1.7 MB) | EPUB
  • 1316 Views
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Open Access
Article
MPET2: a multi-network poroelastic and transport theory for predicting absorption of monoclonal antibodies delivered by subcutaneous injection
Hao Wang, Tianyi Hu, Yu Leng, Mario de Lucio & Hector Gomez
Article: 2163003
Published online: 10 Jan 2023
AbstractforMPET2: a multi-network poroelastic and transport theory for predicting absorption of monoclonal antibodies delivered by subcutaneous injection | Full Text | References | PDF (1.7 MB) | EPUB
  • 1504 Views
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Open Access
Article
Formulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment
Rehab Abdelmonem, Hadel A. Abo El-Enin, Ghada Abdelkader & Mohamed Abdel-Hakeem
Article: 2163321
Published online: 29 Dec 2022
AbstractforFormulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3158 Views
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Open Access
Article
Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable in-situ gel formulation for management of osteoporosis
Wesam H. Abdulaal, Khaled M. Hosny, Nabil A. Alhakamy, Rana B. Bakhaidar, Yasir Almuhanna, Fahad Y. Sabei, Mohammed Alissa, Mohammed Majrashi, Jawaher Abdullah Alamoudi, Mohannad S. Hazzazi, Ayman Jafer & Rasha A. Khallaf
Article: 2164094
Published online: 01 Jan 2023
AbstractforFabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable in-situ gel formulation for management of osteoporosis | Full Text | References | PDF (1.1 MB) | EPUB
  • 2853 Views
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Article
Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye
Dong Wei, Ning Pu, Si-Yu Li, Yan-Ge Wang & Ye Tao
Article: 2165736
Published online: 11 Jan 2023
AbstractforApplication of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye | Full Text | References | PDF (1 MB) | EPUB
  • 3603 Views
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Article

Article
Study of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs
Huahua Li, Ziwei Peng, Yang Song, Minhang Dou, Xinying Lu, Minghui Li, Xiaofeng Zhai, Yan Gu, Rexidanmu· Mamujiang, Shouying Du & Jie Bai
Article: 2165737
Published online: 16 Jan 2023
AbstractforStudy of the permeation-promoting effect and mechanism of solid microneedles on different properties of drugs | Full Text | References | PDF (1.9 MB) | EPUB
  • 1769 Views
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Research Article

Article
Design and evaluation of 32P-labeled hydroxyapatite nanoparticles for bone tumor therapy
Dongliang Zhai, Yumei Wang, Songke Yu, Jiren Zhou, Jia Song, Shilei Hao & Xiaoliang Chen
Article: 2168791
Published online: 23 Jan 2023
AbstractforDesign and evaluation of 32P-labeled hydroxyapatite nanoparticles for bone tumor therapy | Full Text | References | PDF (1.5 MB) | EPUB
  • 1245 Views
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Open Access
Article
Silk nanoparticles for the protection and delivery of guava leaf (Psidium guajava L.) extract for cosmetic industry, a new approach for an old herb
Duy Toan Pham, Doan Xuan Tien Nguyen, Ruby Lieu, Quoc Cuong Huynh, Ngoc Yen Nguyen, Tran Thi Bich Quyen & Van De Tran
Article: 2168793
Published online: 24 Jan 2023
AbstractforSilk nanoparticles for the protection and delivery of guava leaf (Psidium guajava L.) extract for cosmetic industry, a new approach for an old herb | Full Text | References | PDF (1.5 MB) | EPUB
  • 2840 Views
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Article

Article
The preparation and relative bioavailability of an artemisin in self-emulsifying drug delivery system
Sijia Gao, Jingcai Chen, Wanqian Peng, Yang Yang, Yong Yang, Lei Hua, Yanlei Guo, Yunhong Wang & Xiaomei Zhang
Article: 2168794
Published online: 28 Jan 2023
AbstractforThe preparation and relative bioavailability of an artemisin in self-emulsifying drug delivery system | Full Text | References | PDF (931.5 KB) | EPUB
  • 1665 Views
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RESEARCH ARTICLE

Article
Nanotherapy for bone repair: milk-derived small extracellular vesicles delivery of icariin
Xinxin Yu, Ming Dong, Lina Wang, Qian Yang, Long Wang, Wenqing Han, Juhong Dong, Tingjiao Liu, Ying Kong & Weidong Niu
Article: 2169414
Published online: 30 Jan 2023
AbstractforNanotherapy for bone repair: milk-derived small extracellular vesicles delivery of icariin | Full Text | References | PDF (2.8 MB) | EPUB
  • 2023 Views
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Research Article

Article
Novel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy
Yuanlei Fu, Ying Kong, Xiangping Li, Dongfang Cheng, Yuqian Hou, Yan Li, Tongfang Li, Yani Xiao, Qiuyan Zhang & Rong Rong
Article: 2171158
Published online: 06 Feb 2023
AbstractforNovel Pt(IV) prodrug self-assembled nanoparticles with enhanced blood circulation stability and improved antitumor capacity of oxaliplatin for cancer therapy | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2021 Views
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RESEARCH ARTICLE

Article
An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis
Nan Wang, Jie Ma, Wenxia Song & Chengwu Zhao
Article: 2173332
Published online: 01 Feb 2023
AbstractforAn injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3475 Views
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Research Article

Article
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes
Naoya Kato, Sakura Yamada, Rino Suzuki, Yoshiki Iida, Makoto Matsumoto, Shintaro Fumoto, Hidetoshi Arima, Hidefumi Mukai & Shigeru Kawakami
Article: 2173333
Published online: 31 Jan 2023
AbstractforDevelopment of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 3390 Views
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Open Access
Article
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis
Adnan Anjum, Kanwal Shabbir, Fakhar Ud Din, Shumaila Shafique, Syed Saoud Zaidi, Ali H Almari, Taha Alqahtani, Aleena Maryiam, Muhammad Moneeb Khan, Adel Al Fatease, Sidra Bashir & Gul Majid Khan
Article: 2173335
Published online: 01 Feb 2023
AbstractforCo-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2353 Views
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Open Access

Article

Article
Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis
Amal M. Sindi, Waleed Y. Rizg, Muhammad Khalid Khan, Hala M. Alkhalidi, Waleed S. Alharbi, Fahad Y. Sabei, Eman Alfayez, Hanaa Alkharobi, Mohammed Korayem, Mohammed Majrashi, Majed Alharbi, Mohammed Alissa, Awaji Y. Safhi, Abdulmajeed M. Jali & Khaled M. Hosny
Article: 2173337
Published online: 27 Jan 2023
AbstractforTailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis | Full Text | References | PDF (1.5 MB) | EPUB
  • 2489 Views
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Research Article

Article
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation
Syeda Nashvia Adin, Isha Gupta, Md Abdur Rashid, Yahya Alhamhoom, Mohd Aqil & Mohd Mujeeb
Article: 2173338
Published online: 02 Feb 2023
AbstractforNanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 2719 Views
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Open Access
Article
Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice
Ruifeng Mao, Jin Wang, Ying Xu, Yuqi Wang, Mengmeng Wu, Lixia Mao, Yingying Chen, Dengchao Li, Tong Zhang, Enjie Diao, Zhenjing Chi, Yefu Wang & Xin Chang
Article: 2173339
Published online: 31 Jan 2023
AbstractforOral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice | Full Text | References | PDF (1.8 MB) | EPUB
  • 1743 Views
  • 3 CrossRef citations
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Article
Investigating the self-assembling of nicotinic hydrazide-based amphiphile into nano-range vesicles and its amphotericin B loading applications
Kashif Hussain, Abdul Jabbar, Khwaja Ali Hasan, Muneeb Ali, Zaheer Ul-Haq, Muhammad Raza Shah, Saeed Ahmad Khan, Md Abdur Rashid, Mohsin Kazi & Muhammad Naseer Abbas
Article: 2174205
Published online: 13 Feb 2023
AbstractforInvestigating the self-assembling of nicotinic hydrazide-based amphiphile into nano-range vesicles and its amphotericin B loading applications | Full Text | References | PDF (2.2 MB) | EPUB
  • 1523 Views
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Article
Recent progress in nanotechnology-based drug carriers for resveratrol delivery
Chunhong Li, Zhen Wang, Hui Lei & Dan Zhang
Article: 2174206
Published online: 28 Feb 2023
AbstractforRecent progress in nanotechnology-based drug carriers for resveratrol delivery | Full Text | References | PDF (1.6 MB) | EPUB
  • 4591 Views
  • 19 CrossRef citations
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Article
Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity
Dalia A. Gaber, Mahasen A. Radwan, Danah A. Alzughaibi, Jenan A. Alail, Rafa S. Aljumah, Reema M. Aloqla, Sara A. Alkhalifah & Siham A. Abdoun
Article: 2174208
Published online: 06 Feb 2023
AbstractforFormulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity | Full Text | References | PDF (1.3 MB) | EPUB
  • 3056 Views
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Article
Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells
Thikryat Neamatallah, Azizah M. Malebari, Abdulmohsin J. Alamoudi, Syed Nazreen, Mohammad Mahboob Alam, Hawazen H. Bin-Melaih, Osama A. Abuzinadah, Shaimaa M. Badr-Eldin, Gharam Alhassani, Lamar Makki & Mohammed Z. Nasrullah
Article: 2174209
Published online: 10 Feb 2023
AbstractforAndrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells | Full Text | References | PDF (1.9 MB) | EPUB
  • 2455 Views
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RESEARCH ARTICLE

Article
SREKA-targeted liposomes for highly metastatic breast cancer therapy
Balázs Vári, Levente Dókus, Adina Borbély, Anikó Gaál, Diána Vári-Mező, Ivan Ranđelović, Anna Sólyom-Tisza, Zoltán Varga, Norbert Szoboszlai, Gábor Mező & József Tóvári
Article: 2174210
Published online: 08 Feb 2023
AbstractforSREKA-targeted liposomes for highly metastatic breast cancer therapy | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2268 Views
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Article

Article
Research progress of ophthalmic preparations of immunosuppressants
Ye Liu, Haonan Xu, Na Yan, Zhan Tang & Qiao Wang
Article: 2175925
Published online: 10 Feb 2023
AbstractforResearch progress of ophthalmic preparations of immunosuppressants | Full Text | References | PDF (2.1 MB) | EPUB
  • 2602 Views
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Research Article

Article
Arenobufagin-loaded PEG-PLA nanoparticles for reducing toxicity and enhancing cancer therapy
Yang Jiaying, Sun Bo, Wei Xiaolu, Zhou Yanyan, Wang Hongjie, Si Nan, Gao Bo, Wang Linna, Zhang Yan, Gao Wenya, Luo Keke, Jiang Shan, Luo Chuan, Zhao Yu, Zhao Qinghe & Zhao Haiyu
Article: 2177362
Published online: 11 Feb 2023
AbstractforArenobufagin-loaded PEG-PLA nanoparticles for reducing toxicity and enhancing cancer therapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 1977 Views
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RESEARCH ARTICLE

Article
Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke
Shereen A. Sabry, Amal M. Abd El Razek, Mohamed Nabil, Shaimaa M. Khedr, Hanan M. El-Nahas & Noura G. Eissa
Article: 2179127
Published online: 15 Feb 2023
AbstractforBrain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke | Full Text | References | PDF (2.1 MB) | EPUB
  • 2182 Views
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Research Article

Article
A quality by design approach for the synthesis of palmitoyl-L-carnitine-loaded nanoemulsions as drug delivery systems
E. M. Arroyo-Urea, María Muñoz-Hernando, Marta Leo-Barriga, Fernando Herranz & Ana González-Paredes
Article: 2179128
Published online: 19 Feb 2023
AbstractforA quality by design approach for the synthesis of palmitoyl-L-carnitine-loaded nanoemulsions as drug delivery systems | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1698 Views
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Article
A comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration
Sadek Ahmed, Maha M. Amin & Sinar Sayed
Article: 2179129
Published online: 14 Feb 2023
AbstractforA comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration | Full Text | References | PDF (1.8 MB) | EPUB
  • 2108 Views
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Article
Application of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells
Xiaoyan Xu, Tianhao Zhou, Xudong Wei, Xuelian Jiang & Jiyan Cao
Article: 2180112
Published online: 21 Feb 2023
AbstractforApplication of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 1280 Views
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Article
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring
Willem de Laat, Lisa Pagan, R. Karl Malcolm, Maarten Wiegerinck, Victor Nickolson, Bertine Huisman, Rik Stuurman, Michiel van Esdonk & Naomi Klarenbeek
Article: 2180113
Published online: 22 Feb 2023
AbstractforFirst-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 1763 Views
  • 1 CrossRef citations
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Article
Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma
Qian Ju, Rong Huang, Ruimin Hu, Junjie Fan, Dinglin Zhang, Jun Ding & Rong Li
Article: 2181743
Published online: 01 Mar 2023
AbstractforPhytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1977 Views
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Article
Folic acid-modified reverse micelle-lipid nanocapsules overcome intestinal barriers and improve the oral delivery of peptides
Jibiao He, Ruihuan Ding, Yuping Tao, Zhenyu Zhao, Ranran Yuan, Houqian Zhang, Aiping Wang, Kaoxiang Sun, Youxin Li & Yanan Shi
Article: 2181744
Published online: 01 Mar 2023
AbstractforFolic acid-modified reverse micelle-lipid nanocapsules overcome intestinal barriers and improve the oral delivery of peptides | Full Text | References | PDF (1.8 MB) | EPUB
  • 2369 Views
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Article
Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis
Xin Li, Shuang Guan, Henan Li, Dong Li, Dan Liu, Jing Wang, Wenquan Zhu, Guihua Xing, Liling Yue, Defu Cai & Qi Zhang
Article: 2181746
Published online: 21 Feb 2023
AbstractforPolysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis | Full Text | References | PDF (3.1 MB) | EPUB
  • 2226 Views
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Article
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats
Shahinaze A. Fouad, Mahmoud H. Teaima, Mostafa I. Gebril, Fathy I. Abd Allah, Mohamed A. El-Nabarawi & Sammar Fathy Elhabal
Article: 2181747
Published online: 20 Feb 2023
AbstractforFormulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats | Full Text | References | PDF (2.4 MB) | EPUB
  • 2141 Views
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Article
Tumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy
Ru Wang, Nuannuan Li, Tianyu Zhang, Yiying Sun, Xiaoyan He, Xiaoyan Lu, Liuxiang Chu & Kaoxiang Sun
Article: 2182254
Published online: 25 Feb 2023
AbstractforTumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 1609 Views
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Article
Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy
Yuan Gao, Yingxi Zhang, Hong Xia, Yuqing Ren, Haibin Zhang, Siwen Huang, Meiju Li, Yongjun Wang, Heran Li & Hongzhuo Liu
Article: 2183814
Published online: 27 Feb 2023
AbstractforBiomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy | Full Text | References | PDF (4.3 MB) | EPUB
  • 2337 Views
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Article
A detailed insight of the tumor targeting using nanocarrier drug delivery system
Sibgha Batool, Saba Sohail, Fakhar ud Din, Ali H. Alamri, Ahmad S. Alqahtani, Mohammad A. Alshahrani, Mohammed A. Alshehri & Han Gon Choi
Article: 2183815
Published online: 03 Mar 2023
AbstractforA detailed insight of the tumor targeting using nanocarrier drug delivery system | Full Text | References | PDF (1.7 MB) | EPUB
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Review Article

Review Article
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques
Jae Geun Song, Kshitis Chandra Baral, Gyu-Lin Kim, Ji-Won Park, Soo-Hwa Seo, Da-Hyun Kim, Dong Hoon Jung, Nonye Linda Ifekpolugo & Hyo-Kyung Han
Article: 2183816
Published online: 06 Mar 2023
AbstractforQuantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques | Full Text | References | PDF (1.4 MB) | EPUB
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Research Article

Article
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice
Shiyun Xian, Jiabin Zhu, Yuchen Wang, Haihan Song & Hangxiang Wang
Article: 2183821
Published online: 02 Mar 2023
AbstractforOral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice | Full Text | References | PDF (3 MB) | EPUB
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RESEARCH ARTICLE

Article
Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs
Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang & Zhenhai Zhang
Article: 2183830
Published online: 28 Feb 2023
AbstractforExploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs | Full Text | References | PDF (3.3 MB) | EPUB
  • 1483 Views
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Research Article

Article
Preparation and in vivo evaluation of an intravenous emulsion loaded with an aprepitant-phospholipid complex
Yan Li, Hong Yin, Chensi Wu, Jia He, Chunyan Wang, Bo Ren, Heping Wang, Dandan Geng, Yirong Zhang & Ligang Zhao
Article: 2183834
Published online: 27 Feb 2023
AbstractforPreparation and in vivo evaluation of an intravenous emulsion loaded with an aprepitant-phospholipid complex | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1718 Views
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Article
Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model
Prakash Haloi, B. Siva Lokesh, Saurabh Chawla & V. Badireenath Konkimalla
Article: 2184307
Published online: 28 Feb 2023
AbstractforFormulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 3153 Views
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Article
Utilization of experimental design in the formulation and optimization of hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil nanoemulsion for gingivitis
Amal M. Sindi, Khaled M. Hosny, Waleed Y. Rizg, Fahad Y. Sabei, Osama A. Madkhali, Mohammed Ali Bakkari, Eman Alfayez, Hanaa Alkharobi, Samar A Alghamdi, Arwa A. Banjar, Mohammed Majrashi & Mohammed Alissa
Article: 2184311
Published online: 27 Feb 2023
AbstractforUtilization of experimental design in the formulation and optimization of hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil nanoemulsion for gingivitis | Full Text | References | PDF (1.8 MB) | EPUB
  • 2121 Views
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Article
Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode
Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin & Dongzhi Hou
Article: 2184312
Published online: 03 Mar 2023
AbstractforPhysicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode | Full Text | References | PDF (1.7 MB) | EPUB
  • 1787 Views
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Article
Advance in placenta drug delivery: concern for placenta-originated disease therapy
Miao Tang, Xiao Zhang, Weidong Fei, Yu Xin, Meng Zhang, Yao Yao, Yunchun Zhao, Caihong Zheng & Dongli Sun
Article: 2184315
Published online: 08 Mar 2023
AbstractforAdvance in placenta drug delivery: concern for placenta-originated disease therapy | Full Text | References | PDF (2.4 MB) | EPUB
  • 1807 Views
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Article
Design and evaluation of in situ gel eye drops containing nanoparticles of Gemifloxacin Mesylate
Vishwa J. Kalaria, S. Saisivam, Anas Alshishani, Jameel S. Aljariri Alhesan, Sumit Chakraborty & Mohamed Rahamathulla
Article: 2185180
Published online: 06 Mar 2023
AbstractforDesign and evaluation of in situ gel eye drops containing nanoparticles of Gemifloxacin Mesylate | Full Text | References | PDF (1.7 MB) | EPUB
  • 2449 Views
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Article
Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors
Mohammad Souri, Mohammad Kiani Shahvandi, Mohsen Chiani, Farshad Moradi Kashkooli, Ali Farhangi, Mohammad Reza Mehrabi, Arman Rahmim, Van M. Savage & M. Soltani
Article: 2186312
Published online: 09 Mar 2023
AbstractforStimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 2556 Views
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RESEARCH ARTICLE

Article
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy
Yaqin Tu, Wei Zhang, Guorun Fan, Chenming Zou, Jie Zhang, Nan Wu, Jiahui Ding, Wen Qing Zou, Hongjun Xiao & Songwei Tan
Article: 2189106
Published online: 14 Mar 2023
AbstractforPaclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2247 Views
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Research Article

Article
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide
Saeed A. S. Al-Zuhairy, Mahmoud H. Teaima, Nabil A. Shoman, Mohamed Elasaly, Mohamed A. El-Nabarawi & Hossam S. El-Sawy
Article: 2189112
Published online: 14 Mar 2023
AbstractforPEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide | Full Text | References | PDF (2.9 MB) | EPUB
  • 2069 Views
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Article

Article
Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity
Tianyu Zhang, Nuannuan Li, Ru Wang, Yiying Sun, Xiaoyan He, Xiaoyan Lu, Liuxiang Chu & Kaoxiang Sun
Article: 2189118
Published online: 15 Mar 2023
AbstractforEnhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity | Full Text | References | PDF (2.3 MB) | EPUB
  • 2357 Views
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Article
Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management
Haocheng Zhou, Dingquan Zou, Bo Hong, Rong Hu, Tongbiao Yang, Xinning Li, Xin Li, Junjiao Hu, Ruixuan Wang & Yaping Wang
Article: 2189588
Published online: 17 Mar 2023
AbstractforGadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management | Full Text | References | PDF (1.1 MB) | EPUB
  • 2057 Views
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RESEARCH ARTICLE

Article
Merging konjac glucomannan with other copolymeric hydrogels as a cutting-edge liquid raft system for dual delivery of etoricoxib and famotidine
Nabil A. Shoman, Marwa Saady, Mahmoud Teaima, Rehab Abdelmonem, Mohamed A. El-Nabarawi & Sammar Fathy Elhabal
Article: 2189630
Published online: 17 Mar 2023
AbstractforMerging konjac glucomannan with other copolymeric hydrogels as a cutting-edge liquid raft system for dual delivery of etoricoxib and famotidine | Full Text | References | PDF (2.7 MB) | EPUB
  • 1540 Views
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Article
Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives
Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai & Shigeru Kawakami
Article: 2191891
Published online: 25 Mar 2023
AbstractforInvestigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Extravasation of biodegradable microspheres in the rat brain
Anne-Eva van der Wijk, Theodosia Georgakopoulou, Rob Steendam, Johan Zuidema, Peter L. Hordijk, Erik N.T.P. Bakker & Ed van Bavel
Article: 2194579
Published online: 30 Mar 2023
AbstractforExtravasation of biodegradable microspheres in the rat brain | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2657 Views
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Research Article

Article
In vitro comparative study of multimodal imaging nano-assembled microspheres with two clinical drug-eluting beads loaded with doxorubicin
Yiwei He, Tiancheng Xu, Tingting Ding, Yuanchuan Gong, Hui Zeng, Zihan Xi, Yuanxin Ye, Ziyang Song, Ting Pan, Zhewei Zhang, Qian Ma, Lihua Li, Yuqing Zhang & Guoliang Shao
Article: 2197177
Published online: 20 Apr 2023
AbstractforIn vitro comparative study of multimodal imaging nano-assembled microspheres with two clinical drug-eluting beads loaded with doxorubicin | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2660 Views
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Article
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment
Hui Jiang & Zhuping Xu
Article: 2204206
Published online: 16 May 2023
AbstractforHyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment | Full Text | References | PDF (1.6 MB) | EPUB
  • 2979 Views
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Article
Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice
Xiao Wang, Li Fu, Weijian Cheng, Jiamei Chen, Huan Zhang, Huanjun Zhu, Chen Zhang, Chaomei Fu, Yichen Hu & Jinming Zhang
Article: 2204207
Published online: 03 May 2023
AbstractforOral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 3019 Views
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Article
Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases
Lianghui Zhao, Jike Song, Yongle Du, Cong Ren, Bin Guo & Hongsheng Bi
Article: 2219419
Published online: 02 Jun 2023
AbstractforTherapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases | Full Text | References | PDF (1 MB) | EPUB
  • 3592 Views
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Article
Stability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers
Mohamed Mashal, Noha Attia, Santiago Grijalvo, Ramón Eritja, Gustavo Puras & José Luis Pedraz
Article: 2219420
Published online: 15 Jun 2023
AbstractforStability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers | Full Text | References | PDF (1.6 MB) | EPUB
  • 1232 Views
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Article
Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors
Ai Wei Lim, Nicholas J. Talley, Marjorie M. Walker, Gert Storm & Susan Hua
Article: 2219423
Published online: 21 Jun 2023
AbstractforCurrent status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors | Full Text | References | PDF (2.7 MB) | EPUB
  • 2145 Views
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Article
Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy
Wen Zhang, Peng Zhang, Xiaopeng Xu, Minghui Li, Shasha Wang, Hongjie Mu & Kaoxiang Sun
Article: 2219426
Published online: 07 Jun 2023
AbstractforSynergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives
Min Chen, Huanrong Lan, Ketao Jin & Yun Chen
Article: 2219427
Published online: 08 Jun 2023
AbstractforResponsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives | Full Text | References | PDF (1.4 MB) | EPUB
  • 2235 Views
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Article
Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release
Meiyao Wang, Huazhen Xu, Tongfei Li, Ke Li, Quan Zhang, Siyi Chen, Li Zhao, Jincao Chen & Xiao Chen
Article: 2219429
Published online: 02 Jun 2023
AbstractforSonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 1798 Views
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Article
M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver
Xiaochuan Tan, Yumei Hao, Nai Ma, Yige Yang, Wenzhen Jin, Ya Meng, Chuchu Zhou, Wensheng Zheng & Yujia Zhang
Article: 2219432
Published online: 10 Jun 2023
AbstractforM6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1471 Views
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Article
Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability
Ce Yi, Fei Xie, Xin Xu, Dian Xiao, Xinbo Zhou & Maosheng Cheng
Article: 2219433
Published online: 11 Jul 2023
AbstractforGuanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Rationalized design to explore the full potential of PLGA microspheres as drug delivery systems
Rebeca Martinez-Borrajo, Patricia Diaz-Rodriguez & Mariana Landin
Article: 2219864
Published online: 05 Jun 2023
AbstractforRationalized design to explore the full potential of PLGA microspheres as drug delivery systems | Full Text | References | PDF (981.8 KB) | EPUB | Supplemental
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Research article

Article
Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity
Lin Wang, Huanchun Xing, Shuai Guo, Wenbin Cao, Zinan Zhang, Lijuan Huang, Sui Xin, Yuan Luo, Yongan Wang & Jun Yang
Article: 2219869
Published online: 12 Jun 2023
AbstractforNegatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity | Full Text | References | PDF (2.7 MB) | EPUB
  • 1752 Views
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Research Article

Article
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA
Yingying Xu, Yijing Zheng, Xuqiu Ding, Chengyan Wang, Bin Hua, Shilian Hong, Xiaoman Huang, Jiali Lin, Peng Zhang & Wei Chen
Article: 2219870
Published online: 19 Jun 2023
AbstractforPEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2123 Views
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Article
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors
Farshad Moradi Kashkooli, Mohammad Souri, Jahangir (Jahan) Tavakkoli & Michael C. Kolios
Article: 2219871
Published online: 14 Jun 2023
AbstractforA spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1706 Views
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Article
Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution
T. J. Snoeijink, T. G. Vlogman, J. Roosen, E. Groot Jebbink, K. Jain & J.F.W. Nijsen
Article: 2226366
Published online: 21 Jun 2023
AbstractforTransarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1278 Views
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Article
Triptorelin nanoparticle-loaded microneedles for use in assisted reproductive technology
Xiaoyan Lu, Yiying Sun, Meishan Han, Daoyuan Chen, Xiaoyan He, Siqi Wang & Kaoxiang Sun
Article: 2226367
Published online: 30 Jun 2023
AbstractforTriptorelin nanoparticle-loaded microneedles for use in assisted reproductive technology | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1205 Views
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Article
Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system
Jiaqi Weng, Gensuo Zheng, Jiaoli Wen, Jing Yang, Qingliang Yang, Xi Zheng & Qinying Yan
Article: 2232950
Published online: 12 Jul 2023
AbstractforConstruction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system | Full Text | References | PDF (3.5 MB) | EPUB
  • 1721 Views
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Article
A click chemistry-based, free radical-initiated delivery system for the capture and release of payloads
Emily T. DiMartini, Kelly Kyker-Snowman & David I. Shreiber
Article: 2232952
Published online: 11 Jul 2023
AbstractforA click chemistry-based, free radical-initiated delivery system for the capture and release of payloads | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Sustained release gel (polymer-free) of itraconazole-loaded microemulsion for oral candidiasis treatment: time-kill kinetics and cellular uptake
Sukannika Tubtimsri & Yotsanan Weerapol
Article: 2234099
Published online: 14 Jul 2023
AbstractforSustained release gel (polymer-free) of itraconazole-loaded microemulsion for oral candidiasis treatment: time-kill kinetics and cellular uptake | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1038 Views
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Article
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules
Ashif Iqubal, Abul Kalam Najmi, Shadab Md, Huda Mohammed Alkreathy, Javed Ali, Mansoor Ali Syed & Syed Ehtaishamul Haque
Article: 2241661
Published online: 09 Aug 2023
AbstractforOral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules | Full Text | References | PDF (17.6 MB) | EPUB
  • 1939 Views
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Article
Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis
Xiao-Xiao Fu, Han Qu, Jing Wang, Hua-Ying Cai, Hong Jiang, Hao-Hao Chen & Shu Han
Article: 2241664
Published online: 06 Aug 2023
AbstractforNovel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
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Article
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro, in silico, and in-vivo study
Sammar Fathy Elhabal, Mohamed A El-Nabarawi, Nashwa Abdelaal, Mohamed Fathi Mohamed Elrefai, Shrouk A. Ghaffar, Mohamed Mansour Khalifa, Passant M. Mohie, Dania S. Waggas, Ahmed Mohsen Elsaid Hamdan, Samar Zuhair Alshawwa, Essa M. Saied, Nahla A. Elzohairy, Tayseer Elnawawy, Rania A. Gad, Nehal Elfar, Hanaa Mohammed & Mohammad Ahmad Khasawneh
Article: 2241665
Published online: 03 Aug 2023
AbstractforDevelopment of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro, in silico, and in-vivo study | Full Text | References | PDF (2.4 MB) | EPUB
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Drug Delivery

Article
An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications
Wenqing Liang, Chao Zhou, Songtao Jin, Lifeng Fu, Hengjian Zhang, Xiaogang Huang, Hengguo Long, Wenyi Ming & Jiayi Zhao
Article: 2241667
Published online: 01 Dec 2023
AbstractforAn update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications | Full Text | References | PDF (6 MB) | EPUB
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Research Article

Article
Sustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss
Thu Nhan Nguyen, So-Yeol Yoo, Warisraporn Tangchang, Jae-Young Lee, Hwa-Young Son & Jeong-Sook Park
Article: 2242003
Published online: 03 Aug 2023
AbstractforSustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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RESEARCH ARTICLE

Article
Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia
G.R. Nirmal, Chia-Chih Liao, Zih-Chan Lin, Abdullah Alshetaili, Erica Hwang, Shih-Chun Yang & Jia-You Fang
Article: 2245169
Published online: 10 Aug 2023
AbstractforTopically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Research Article

Article
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model
Kainat Nousheen, Fakhar Ud Din, Humzah Jamshaid, Rabia Afza, Saif Ullah Khan, Maimoona Malik, Zakir Ali, Sibgha Batool, Alam Zeb, Abid Mehmood Yousaf, Ali H. Almari, Saud Alqahtani, Salman Khan & Gul Majid Khan
Article: 2251720
Published online: 30 Aug 2023
AbstractforMetformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Review Article

Review Article
Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model
Robert J. Connor, Renee Clift & David W. Kang
Article: 2252999
Published online: 13 Sep 2023
AbstractforIdentifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Review Article
Kartogenin delivery systems for biomedical therapeutics and regenerative medicine
Peixing Chen & Xiaoling Liao
Article: 2254519
Published online: 04 Sep 2023
AbstractforKartogenin delivery systems for biomedical therapeutics and regenerative medicine | Full Text | References | PDF (2.1 MB) | EPUB
  • 1383 Views
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Research Article

Article
Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions
Shimaa A. Elbanna, Heba M. K. Ebada, Ossama Y. Abdallah, Marwa M. Essawy, Hend M. Abdelhamid & Hebatallah S. Barakat
Article: 2254530
Published online: 05 Sep 2023
AbstractforNovel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 1541 Views
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Review Article

Review Article
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases
Xinyu Wang & Ruru Bai
Article: 2256495
Published online: 13 Sep 2023
AbstractforAdvances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases | Full Text | References | PDF (3.3 MB) | EPUB
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Research Article

Article
Spray-dried nanocrystal-loaded polymer microparticles for long-term release local therapies: an opportunity for poorly soluble drugs
Carlos Rodríguez-Nogales, Joke Meeus, Gaby Thonus, Sam Corveleyn, Eric Allémann & Olivier Jordan
Article: 2284683
Published online: 22 Nov 2023
AbstractforSpray-dried nanocrystal-loaded polymer microparticles for long-term release local therapies: an opportunity for poorly soluble drugs | Full Text | References | PDF (6.2 MB) | EPUB | Supplemental
  • 881 Views
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Review Article

Review Article
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum
Koyeli Girigoswami, Pragya Pallavi & Agnishwar Girigoswami
Article: 2284684
Published online: 21 Nov 2023
AbstractforIntricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum | Full Text | References | PDF (9.5 MB) | EPUB
  • 1904 Views
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Review Article
Lipidization as a tool toward peptide therapeutics
Aneta Myšková, David Sýkora, Jaroslav Kuneš & Lenka Maletínská
Article: 2284685
Published online: 27 Nov 2023
AbstractforLipidization as a tool toward peptide therapeutics | Full Text | References | PDF (2.7 MB) | EPUB
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Review Article
Platinum-based drugs and hydrogel: a promising anti-tumor combination
Jiamin Yao, Shaojuan Song, Hang Zhao & Yao Yuan
Article: 2287966
Published online: 11 Dec 2023
AbstractforPlatinum-based drugs and hydrogel: a promising anti-tumor combination | Full Text | References | PDF (8.4 MB) | EPUB
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Review Article
Multifunctional cell membranes-based nano-carriers for targeted therapies: a review of recent trends and future perspective
Mo Li, Qiushi Guo, Chongli Zhong & Ziyan Zhang
Article: 2288797
Published online: 09 Dec 2023
AbstractforMultifunctional cell membranes-based nano-carriers for targeted therapies: a review of recent trends and future perspective | Full Text | References | PDF (9.6 MB) | EPUB
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Review Article
The direct transfer approach for transcellular drug delivery
Yi-Fan Wang, Ze-Fan Shen, Fang-yue Xiang, Heng Wang, Pu Zhang & Qi Zhang
Article: 2288799
Published online: 30 Nov 2023
AbstractforThe direct transfer approach for transcellular drug delivery | Full Text | References | PDF (2.1 MB) | EPUB
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Review Article
Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases
Manxiang Wu, Chengyuan Hong, Chunjuan Shen, Dong Xie, Tianxiang Chen, Aiguo Wu & Qiang Li
Article: 2289846
Published online: 09 Dec 2023
AbstractforPolydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases | Full Text | References | PDF (11.4 MB) | EPUB
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Ferric-loaded lipid nanoparticles inducing ferroptosis-like cell death for antibacterial wound healing
Ying Zhou, Chong-Yang Cai, Cheng Wang, Guo-Ming Hu, Yu-Ting Li, Meng-Jiao Han, Shen Hu & Pu Cheng
Pages: 1-8
Published online: 01 Dec 2022
AbstractforFerric-loaded lipid nanoparticles inducing ferroptosis-like cell death for antibacterial wound healing | Full Text | References | PDF (1.3 MB) | EPUB
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The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma
Haoyue Xu, Yongkang Zhang, Linfeng Li, Yanhong Ren, Feng Qian, Lansheng Wang, Hongwei Ma, Ankang Quan, Hongmei Liu & Rutong Yu
Pages: 1-13
Published online: 29 Dec 2022
AbstractforThe nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Recent advances in drug delivery systems for targeting brain tumors
Yi Zhao, Ping Yue, Yao Peng, Yuanyuan Sun, Xing Chen, Ze Zhao & Bingjie Han
Pages: 1-18
Published online: 03 Jan 2023
AbstractforRecent advances in drug delivery systems for targeting brain tumors | Full Text | References | PDF (2.1 MB) | EPUB
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Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer
Ai-Ho Liao, Yu-An Lee, Dao-Lung Lin, Ho-Chiao Chuang, Jehng-Kang Wang, Ching-En Chang, Hsiang-Tzu Li, Ting-Yi Wu, Cheng-Ping Shih, Chih-Hung Wang & Yueng-Hsiang Chu
Pages: 1-13
Published online: 29 Dec 2022
AbstractforTreatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor
Hailing Tang, Changhui Cao, Guangyuan Zhang & Zhengkao Sun
Pages: 1-16
Published online: 16 Jan 2023
AbstractforImpact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor | Full Text | References | PDF (2.6 MB) | EPUB
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Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment
Ling Zhang, Bing-Zhong Zhai, Yue-Jin Wu & Yin Wang
Pages: 1-18
Published online: 03 Jan 2023
AbstractforRecent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment | Full Text | References | PDF (2.5 MB) | EPUB
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Immunomodulatory nano-preparations for rheumatoid arthritis
Chenglong Li, Yangyun Han, Xianjin Luo, Can Qian, Yang Li, Huaiyu Su & Guangshen Du
Pages: 9-19
Published online: 08 Dec 2022
AbstractforImmunomodulatory nano-preparations for rheumatoid arthritis | Full Text | References | PDF (1.3 MB) | EPUB
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HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning
Liao Shen, Yadan Zhang, Qimei Cai, Jun Yang, Yongan Wang & Dongqin Quan
Pages: 20-27
Published online: 30 Nov 2022
AbstractforHI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning | Full Text | References | PDF (1,013.5 KB) | EPUB
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Aptamer-mediated hollow MnO2 for targeting the delivery of sorafenib
Ziyue Wang, Cuicui Wu, Jinren Liu, Shunxin Hu, Junli Yu, Qiangqiamg Yin, Hongda Tian, Zhipeng Ding, Guiqiang Qi, Li Wang & Liguo Hao
Pages: 28-39
Published online: 01 Dec 2022
AbstractforAptamer-mediated hollow MnO2 for targeting the delivery of sorafenib | Full Text | References | PDF (2.6 MB) | EPUB
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Polysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells
Peng Dong, Hongshuai Lv, Weiping Jia, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao & Yikang Shi
Pages: 40-50
Published online: 01 Dec 2022
AbstractforPolysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Risedronate-loaded aerogel scaffolds for bone regeneration
Nahla El-Wakil, Rabab Kamel, Azza A. Mahmoud, Alain Dufresne, Ragab E. Abouzeid, Mahmoud T. Abo El-Fadl & Amr Maged
Pages: 51-63
Published online: 06 Dec 2022
AbstractforRisedronate-loaded aerogel scaffolds for bone regeneration | Full Text | References | PDF (2.1 MB) | EPUB
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Effect and mechanism of paclitaxel loaded on magnetic Fe3O4@mSiO2-NH2-FA nanocomposites to MCF-7 cells
Yun Ni, Peng Deng, Ruitong Yin, Ziye Zhu, Chen Ling, Mingyi Ma, Jie Wang, Shasha Li & Ruijiang Liu
Pages: 64-82
Published online: 06 Dec 2022
AbstractforEffect and mechanism of paclitaxel loaded on magnetic Fe3O4@mSiO2-NH2-FA nanocomposites to MCF-7 cells | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Utilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line
Raed I. Felimban, Hossam H. Tayeb, Adeel G Chaudhary, Majed A. Felemban, Fuad H. Alnadwi, Sarah A. Ali, Jazia A. Alblowi, Eman ALfayez, Deena Bukhary, Mohammed Alissa & Safa H. Qahl
Pages: 83-96
Published online: 12 Dec 2022
AbstractforUtilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line | Full Text | References | PDF (1.6 MB) | EPUB
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Blood-cerebrospinal fluid barrier opening by modified single pulse transcranial focused shockwave
Yi Kung, Chueh-Hung Wu, Meng-Ting Lin, Wei-Hao Liao, Wen-Shiang Chen & Ming-Yen Hsiao
Pages: 97-107
Published online: 19 Dec 2022
AbstractforBlood-cerebrospinal fluid barrier opening by modified single pulse transcranial focused shockwave | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1674 Views
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Mesoporous tantalum oxide nanomaterials induced cardiovascular endothelial cell apoptosis via mitochondrial-endoplasmic reticulum stress apoptotic pathway
Yuanyong Jiao, Xiwei Zhang, Hongyu Yang, Hao Ma & Junjie Zou
Pages: 108-120
Published online: 19 Dec 2022
AbstractforMesoporous tantalum oxide nanomaterials induced cardiovascular endothelial cell apoptosis via mitochondrial-endoplasmic reticulum stress apoptotic pathway | Full Text | References | PDF (3.2 MB) | EPUB
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Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis
Weiman Zhao, Lijie Zheng, Jianhui Yang, Zihui Ma, Xinyi Tao & Qingqing Wang
Pages: 121-132
Published online: 19 Dec 2022
AbstractforDissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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