Expert Opinion on Drug Discovery, Volume 15, Issue 4 (2020)

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Expert Opinion on Drug Discovery, Volume 15, Issue 4 (2020)

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Editorial

Editorial
What translatable knowledge from dengue vaccine design can we pass onto future anti-parasitic vaccine development?
Anon Srikiatkhachorn
Pages: 391-395
Published online: 11 Feb 2020
First Page PreviewforWhat translatable knowledge from dengue vaccine design can we pass onto future anti-parasitic vaccine development? | Full Text | References | PDF (449.9 KB) | EPUB
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Editorial
Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
Alan Talevi & Carolina L. Bellera
Pages: 397-401
Published online: 17 Dec 2019
First Page PreviewforChallenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics | Full Text | References | PDF (571 KB) | EPUB
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Drug Discovery Case History

Article
Preclinical discovery and development of evolocumab for the treatment of hypercholesterolemia
Etienne Khoury, Diane Brisson & Daniel Gaudet
Pages: 403-414
Published online: 23 Jan 2020
AbstractforPreclinical discovery and development of evolocumab for the treatment of hypercholesterolemia | Full Text | References | PDF (1.2 MB) | EPUB
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Special Report

Article
Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites
Hanh H. T. Nguyen, Lee M. Yeoh, Scott A. Chisholm & Michael F. Duffy
Pages: 415-425
Published online: 23 Dec 2019
AbstractforDevelopments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites | Full Text | References | PDF (1.2 MB) | EPUB
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Review

Review
Organoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discovery
Nick Marotta, Soojin Kim & Dimitri Krainc
Pages: 427-441
Published online: 03 Jan 2020
AbstractforOrganoid and pluripotent stem cells in Parkinson’s disease modeling: an expert view on their value to drug discovery | Full Text | References | PDF (1.2 MB) | EPUB
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Review
Duchenne muscular dystrophy animal models for high-throughput drug discovery and precision medicine
Nalinda B. Wasala, Shi-Jie Chen & Dongsheng Duan
Pages: 443-456
Published online: 30 Jan 2020
AbstractforDuchenne muscular dystrophy animal models for high-throughput drug discovery and precision medicine | Full Text | References | PDF (1.4 MB) | EPUB
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Review
Strategies for targeting the cardiac sarcomere: avenues for novel drug discovery
Joshua B. Holmes, Chang Yoon Doh, Ranganath Mamidi, Jiayang Li & Julian E. Stelzer
Pages: 457-469
Published online: 18 Feb 2020
AbstractforStrategies for targeting the cardiac sarcomere: avenues for novel drug discovery | Full Text | References | PDF (1.8 MB) | EPUB
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Review
Modulators of calpain activity: inhibitors and activators as potential drugs
Levente Endre Dókus, Mo’ath Yousef & Zoltán Bánóczi
Pages: 471-486
Published online: 05 Feb 2020
AbstractforModulators of calpain activity: inhibitors and activators as potential drugs | Full Text | References | PDF (1.7 MB) | EPUB
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Review
An overview of drug discovery efforts for eczema: why is this itch so difficult to scratch?
Kam Lun Hon, Steven Loo, Alexander K. C. Leung, Joyce T. S. Li & Vivian W. Y. Lee
Pages: 487-498
Published online: 13 Feb 2020
AbstractforAn overview of drug discovery efforts for eczema: why is this itch so difficult to scratch? | Full Text | References | PDF (1.2 MB) | EPUB
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Review
Metabolomic tools used in marine natural product drug discovery
Kevin Andrew Stuart, Keira Welsh, Molly Clare Walker & RuAngelie Edrada-Ebel
Pages: 499-522
Published online: 06 Feb 2020
AbstractforMetabolomic tools used in marine natural product drug discovery | Full Text | References | PDF (2.7 MB) | EPUB
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