Expert Opinion on Drug Discovery, Volume 18, Issue 11 (2023)

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Expert Opinion on Drug Discovery, Volume 18, Issue 11 (2023)

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Editorial

Editorial
Opportunities and challenges in new HIV therapeutic discovery: what is the next step?
Shujing Xu, Lin Sun, Xinyong Liu & Peng Zhan
Pages: 1195-1199
Published online: 10 Aug 2023
First Page PreviewforOpportunities and challenges in new HIV therapeutic discovery: what is the next step? | Full Text | References | PDF (939.9 KB) | EPUB
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Drug Discovery Case History

Article
The preclinical discovery and development of deucravacitinib for the treatment of psoriasis
Giulia Coscarella, Dalma Malvaso, Maria Mannino, Giacomo Caldarola, Barbara Fossati, Clara De Simone, Andrea Chiricozzi & Ketty Peris
Pages: 1201-1208
Published online: 13 Aug 2023
AbstractforThe preclinical discovery and development of deucravacitinib for the treatment of psoriasis | Full Text | References | PDF (1.6 MB) | EPUB
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Perspective

Recent advances in measurement of metabolic clearance, metabolite profile and reaction phenotyping of low clearance compounds
Li Di
Pages: 1209-1219
Published online: 01 Aug 2023
AbstractforRecent advances in measurement of metabolic clearance, metabolite profile and reaction phenotyping of low clearance compounds | Full Text | References | PDF (497.1 KB) | EPUB
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Review

Review Article
The current role and evolution of X-ray crystallography in drug discovery and development
Vanessa Bijak, Michal Szczygiel, Joanna Lenkiewicz, Michal Gucwa, David R. Cooper, Krzysztof Murzyn & Wladek Minor
Pages: 1221-1230
Published online: 17 Aug 2023
AbstractforThe current role and evolution of X-ray crystallography in drug discovery and development | Full Text | References | PDF (2.5 MB) | EPUB
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Review Article
Optimizing drug discovery using multitasking models for quantitative structure–biological effect relationships: an update of the literature
Valeria V. Kleandrova, M. Natália D. S. Cordeiro & Alejandro Speck-Planche
Pages: 1231-1243
Published online: 28 Aug 2023
AbstractforOptimizing drug discovery using multitasking models for quantitative structure–biological effect relationships: an update of the literature | Full Text | References | PDF (2.2 MB) | EPUB
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Review Article
Deep learning tools to accelerate antibiotic discovery
Angela Cesaro, Mojtaba Bagheri, Marcelo Torres, Fangping Wan & Cesar de la Fuente-Nunez
Pages: 1245-1257
Published online: 18 Oct 2023
AbstractforDeep learning tools to accelerate antibiotic discovery | Full Text | References | PDF (2.6 MB) | EPUB
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Review Article
Applications of machine learning in microbial natural product drug discovery
Autumn Arnold, Jeremie Alexander, Gary Liu & Jonathan M. Stokes
Pages: 1259-1272
Published online: 31 Aug 2023
AbstractforApplications of machine learning in microbial natural product drug discovery | Full Text | References | PDF (1.9 MB) | EPUB
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Review Article
Mapping strategies towards improved external validity in preclinical translational research
Clarissa F. D. Carneiro, Natascha Drude, Maren Hülsemann, Anja Collazo & Ulf Toelch
Pages: 1273-1285
Published online: 10 Sep 2023
AbstractforMapping strategies towards improved external validity in preclinical translational research | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Review Article
Exploring the current use of animal models in glaucoma drug discovery: where are we in 2023?
Renu Agarwal, Puneet Agarwal & Igor Iezhitsa
Pages: 1287-1300
Published online: 22 Aug 2023
AbstractforExploring the current use of animal models in glaucoma drug discovery: where are we in 2023? | Full Text | References | PDF (1.2 MB) | EPUB
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