Expert Opinion on Drug Discovery, Volume 3, Issue 1 (2008)

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Expert Opinion on Drug Discovery, Volume 3, Issue 1 (2008)

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Reviews

Article
In vitro three-dimensional tumor microenvironment models for anticancer drug discovery
Keiran SM Smalley, Mercedes Lioni, Kazuhiro Noma, Nikolas K Haass & Meenhard Herlyn
Pages: 1-10
Published online: 19 Dec 2007
AbstractforIn vitro three-dimensional tumor microenvironment models for anticancer drug discovery | Full Text | References | PDF (1.2 MB)
  • 755 Views
  • 88 CrossRef citations
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Article
Targeting TGFβ signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer: effect of halofuginone
Mark Pines PhD
Pages: 11-20
Published online: 19 Dec 2007
AbstractforTargeting TGFβ signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer: effect of halofuginone | Full Text | References | PDF (655.6 KB)
  • 195 Views
  • 35 CrossRef citations
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Article
Development of new antituberculous agents based on new drug targets and structure–activity relationship
Haruaki Tomioka Phd, Professor
Pages: 21-49
Published online: 19 Dec 2007
AbstractforDevelopment of new antituberculous agents based on new drug targets and structure–activity relationship | Full Text | References | PDF (282.2 KB)
  • 162 Views
  • 6 CrossRef citations
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Article
The apelin peptides as putative targets in cardiovascular drug discovery and development
CJ Charles PhD
Pages: 51-64
Published online: 19 Dec 2007
AbstractforThe apelin peptides as putative targets in cardiovascular drug discovery and development | Full Text | References | PDF (284.8 KB)
  • 75 Views
  • 3 CrossRef citations
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Article
Huprines for Alzheimer's disease drug development
Diego Muñoz-Torrero & Pelayo Camps
Pages: 65-81
Published online: 19 Dec 2007
AbstractforHuprines for Alzheimer's disease drug development | Full Text | References | PDF (1.4 MB)
  • 97 Views
  • 18 CrossRef citations
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Article
Animal models for drug discovery in dystonia
HA Jinnah MD PhD, Angelika Richter, Jonathon W Mink, Guy A Caldwell, Kim A Caldwell, Pedro Gonzalez-Alegre, Mark R Cookson, Xandra O Breakefield, Mahlon R Delong & Ellen J Hess
Pages: 83-97
Published online: 19 Dec 2007
AbstractforAnimal models for drug discovery in dystonia | Full Text | References | PDF (192.4 KB)
  • 181 Views
  • 21 CrossRef citations
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Article
Discovery and development of purine-scaffold Hsp90 inhibitors
Gabriela Chiosis, Yanlong Kang & Weilin Sun
Pages: 99-114
Published online: 19 Dec 2007
AbstractforDiscovery and development of purine-scaffold Hsp90 inhibitors | Full Text | References | PDF (620.5 KB)
  • 186 Views
  • 25 CrossRef citations
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Article
Developing assays for kinase drug discovery – where have the advances come from?
Kurt W Vogel, Zhong Zhong, Kun Bi & Brian A Pollok
Pages: 115-129
Published online: 19 Dec 2007
AbstractforDeveloping assays for kinase drug discovery – where have the advances come from? | Full Text | References | PDF (903.6 KB)
  • 229 Views
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Case History

Article
Seliciclib, a cell-cycle modulator that acts through the inhibition of cyclin-dependent kinases
Robert C Jackson PhD, Anna L Barnett PhD, Steven J McClue PhD & Simon R Green PhD
Pages: 131-143
Published online: 19 Dec 2007
AbstractforSeliciclib, a cell-cycle modulator that acts through the inhibition of cyclin-dependent kinases | Full Text | References | PDF (218.8 KB)
  • 149 Views
  • 16 CrossRef citations
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