Expert Opinion on Investigational Drugs, Volume 18, Issue 2 (2009)

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Expert Opinion on Investigational Drugs, Volume 18, Issue 2 (2009)

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Discontinued Drugs Perspective

Article
Discontinued drugs 2007: central and peripheral nervous system drugs
Bjarke Ebert PhD DSc
Pages: 109-123
Published online: 21 Jan 2009
AbstractforDiscontinued drugs 2007: central and peripheral nervous system drugs | Full Text | References | PDF (415.3 KB)
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Reviews

Article
Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective
Matthias Karst MD PhD & Sonja Wippermann
Pages: 125-133
Published online: 21 Jan 2009
AbstractforCannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective | Full Text | References | PDF (239.8 KB)
  • 575 Views
  • 21 CrossRef citations
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Review

Article
Endothelin receptor antagonism in portal hypertension
Kelly R Pitts PhD
Pages: 135-142
Published online: 24 Dec 2008
AbstractforEndothelin receptor antagonism in portal hypertension | Full Text | References | PDF (261.1 KB)
  • 135 Views
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Article
Experimental therapies in Ewing's sarcoma
Rachael Windsor BSc MBBS MSc, Sandra Strauss, Beatrice Seddon & Jeremy Whelan
Pages: 143-159
Published online: 21 Jan 2009
AbstractforExperimental therapies in Ewing's sarcoma | Full Text | References | PDF (335.5 KB)
  • 169 Views
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Article
Heat shock protein inhibitors and vaccines as new agents in cancer treatment
Eleni M Karapanagiotou, Kostas Syrigos & Muhammad Wasif Saif MD MBBS
Pages: 161-174
Published online: 21 Jan 2009
AbstractforHeat shock protein inhibitors and vaccines as new agents in cancer treatment | Full Text | References | PDF (2 MB)
  • 154 Views
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Article
mTOR-blocking agents in advanced renal cancer: an emerging therapeutic option
Constantin A Dasanu, Bernard A Clark III & Doru T Alexandrescu
Pages: 175-187
Published online: 21 Jan 2009
AbstractformTOR-blocking agents in advanced renal cancer: an emerging therapeutic option | Full Text | References | PDF (426.9 KB)
  • 136 Views
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Drug Evaluations

Article
A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P)
Dietmar W Siemann PhD, David J Chaplin PhD & Patricia A Walicke MD PhD
Pages: 189-197
Published online: 21 Jan 2009
AbstractforA review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P) | Full Text | References | PDF (2.3 MB)
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Drug Evaluation

Article
Apricitabine – a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs
Susan Cox PhD & Justine Southby PhD
Pages: 199-209
Published online: 15 Dec 2008
AbstractforApricitabine – a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs | Full Text | References | PDF (350.3 KB)
  • 59 Views
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Article
An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C
Raf Crabbé, Grégoire Vuagniaux, Jean-Maurice Dumont, Valérie Nicolas-Métral, Judith Marfurt & Laura Novaroli
Pages: 211-220
Published online: 15 Dec 2008
AbstractforAn evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C | Full Text | References | PDF (361.4 KB)
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Article
Eslicarbazepine acetate: a new option for the treatment of focal epilepsy
Joaquim Ferreira & Tiago Mestre
Pages: 221-229
Published online: 15 Dec 2008
AbstractforEslicarbazepine acetate: a new option for the treatment of focal epilepsy | Full Text | References | PDF (277 KB)
  • 121 Views
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Article
Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia
Kenneth I Ataga MBBS & Jonathan Stocker PhD
Pages: 231-239
Published online: 21 Jan 2009
AbstractforSenicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia | Full Text | References | PDF (356.1 KB)
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Key Paper Evaluation

Article
HIF-1α inhibition as a novel mechanism of cardiac glycosides in cancer therapeutics
Evaluation of: Zhang H, Qian DZ, Tan YS, et al. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth. Proc Natl Acad Sci USA 2008;105:19579-86
Jianqing Lin & Michael A Carducci
Pages: 241-243
Published online: 21 Jan 2009
AbstractforHIF-1α inhibition as a novel mechanism of cardiac glycosides in cancer therapeutics | Full Text | References | PDF (211.4 KB)
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