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Volume 30, Issue 5

Expert Opinion on Investigational Drugs

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Expert Opinion on Investigational Drugs, Volume 30, Issue 5 (2021)

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Expert Opinion on Investigational Drugs, Volume 30, Issue 5 (2021)

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Vol 33, 2024 Vol 32, 2023 Vol 31, 2022 Volume 30, 2021 Vol 29, 2020 Vol 28, 2019 Vol 27, 2018 Vol 26, 2017 Vol 25, 2016 Vol 24, 2015 Vol 23, 2014 Vol 22, 2013 Vol 21, 2012 Vol 20, 2011 Vol 19, 2010 Vol 18, 2009 Vol 17, 2008 Vol 16, 2007 Vol 15, 2006 Vol 14, 2005 Vol 13, 2004 Vol 12, 2003 Vol 11, 2002 Vol 10, 2001 Vol 9, 2000 Vol 8, 1999 Vol 7, 1998 Vol 6, 1997 Vol 5, 1996 Vol 4, 1995 Vol 3, 1994

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Editorial

Investigational topical anticholinergics in clinical development for the treatment of hyperhidrosis

Stamatios Gregoriou, Anna Campanati, Dimitrios Rigopoulos, Anna Maria Offidani, Alexandros Stratigos & George Kontochristoulos

Pages: 479-482

Published online: 16 Apr 2021

First Page PreviewforInvestigational topical anticholinergics in clinical development for the treatment of hyperhidrosis | Full Text | References | PDF (215.4 KB) | EPUB

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Drug evaluation

Article

Zilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody–Positive Generalized Myasthenia Gravis

James F. Howard Jr., John Vissing, Nils E. Gilhus, M. Isabel Leite, Kimiaki Utsugisawa, Petra W. Duda, Ramin Farzaneh-Far, Hiroyuki Murai & Heinz Wiendl

Pages: 483-493

Published online: 01 Apr 2021

AbstractforZilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody–Positive Generalized Myasthenia Gravis | Full Text | References | PDF (2.9 MB) | EPUB

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Open Access

Drug Evaluation

Article

MK-6482 as a potential treatment for von Hippel-Lindau disease-associated clear cell renal cell carcinoma

Elshad Hasanov & Eric Jonasch

Pages: 495-504

Published online: 20 May 2021

AbstractforMK-6482 as a potential treatment for von Hippel-Lindau disease-associated clear cell renal cell carcinoma | Full Text | References | PDF (2.5 MB) | EPUB

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Perspective

Article

The time to offer treatments for COVID-19

Binh T. Ngo, Paul Marik, Pierre Kory, Leland Shapiro, Raphael Thomadsen, Jose Iglesias, Stephen Ditmore, Marc Rendell, Joseph Varon, Michael Dubé, Neha Nanda, Gino In, Daniel Arkfeld, Preet Chaudhary, Vito M. Campese, Diana L. Hanna, David E. Sawcer, Glenn Ehresmann, David Peng, Miroslaw Smogorewski, April Armstrong, Rajkumar Dasgupta, Fred Sattler, Denise Brennan-Rieder, Cristina Mussini, Oriol Mitja, Vicente Soriano, Nicolas Peschanski, Gilles Hayem, Marco Confalonieri, Maria Carmela Piccirillo, Antonio Lobo-Ferreira, Iraldo Bello Rivero, Mika Turkia, Eivind H. Vinjevoll, Daniel Griffin & Ivan Fn Hung

Pages: 505-518

Published online: 23 Apr 2021

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Review

Therapeutic interventions for spinal muscular atrophy: preclinical and early clinical development opportunities

Laurent Servais, Giovanni Baranello, Mariacristina Scoto, Aurore Daron & Maryam Oskoui

Pages: 519-527

Published online: 13 Apr 2021

AbstractforTherapeutic interventions for spinal muscular atrophy: preclinical and early clinical development opportunities | Full Text | References | PDF (1.3 MB) | EPUB

768 Views
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Neoantigen vaccine platforms in clinical development: understanding the future of personalized immunotherapy

Suangson Supabphol, Lijin Li, S. Peter Goedegebuure & William E. Gillanders

Pages: 529-541

Published online: 31 Mar 2021

AbstractforNeoantigen vaccine platforms in clinical development: understanding the future of personalized immunotherapy | Full Text | References | PDF (1.9 MB) | EPUB

1163 Views
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Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know

Luigi Della Corte, Virginia Foreste, Claudia, Di Filippo, Pierluigi Giampaolino & Giuseppe Bifulco

Pages: 543-554

Published online: 24 Mar 2021

AbstractforPoly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know | Full Text | References | PDF (408 KB) | EPUB

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Immunotherapy in uveal melanoma: novel strategies and opportunities for personalized treatment

Christos Masaoutis, Stefania Kokkali & Stamatios Theocharis

Pages: 555-569

Published online: 11 Mar 2021

AbstractforImmunotherapy in uveal melanoma: novel strategies and opportunities for personalized treatment | Full Text | References | PDF (1.2 MB) | EPUB

350 Views
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Investigational neuroprotective compounds in clinical trials for retinal disease

Daniel Hill, Chiara Compagnoni & M. Francesca Cordeiro

Pages: 571-577

Published online: 01 Apr 2021

AbstractforInvestigational neuroprotective compounds in clinical trials for retinal disease | Full Text | References | PDF (320.5 KB) | EPUB

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Open Access

Original Research

Article

Safety, tolerability, and pharmacokinetics of the novel pan-phosphodiesterase inhibitor ZSP1601 in healthy subjects: a double-blinded, placebo-controlled first-in-human single-dose and multiple-dose escalation and food effect study

Xiaoxue Zhu, Min Wu, Hong Wang, Haijun Li, Junjie Lin, Yun Peng, Yue Hu, Cuiyun Li & Yanhua Ding

Pages: 579-589

Published online: 25 Mar 2021

AbstractforSafety, tolerability, and pharmacokinetics of the novel pan-phosphodiesterase inhibitor ZSP1601 in healthy subjects: a double-blinded, placebo-controlled first-in-human single-dose and multiple-dose escalation and food effect study | Full Text | References | PDF (1.5 MB) | EPUB

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