Expert Opinion on Investigational Drugs, Volume 31, Issue 5 (2022)

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Expert Opinion on Investigational Drugs, Volume 31, Issue 5 (2022)

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Drug Evaluation

Article
Tucatinib: an investigational novel therapeutic agent for the treatment of HER-2 colorectal cancer
Daniel Ahn, Daniel Walden & Tanios Bekaii-Saab
Pages: 437-441
Published online: 17 Mar 2022
AbstractforTucatinib: an investigational novel therapeutic agent for the treatment of HER-2 colorectal cancer | Full Text | References | PDF (297.4 KB) | EPUB
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Article
KSI-301: an investigational anti-VEGF biopolymer conjugate for retinal diseases
Hudson D. Stern & Rehan M Hussain
Pages: 443-449
Published online: 16 Mar 2022
AbstractforKSI-301: an investigational anti-VEGF biopolymer conjugate for retinal diseases | Full Text | References | PDF (497.4 KB) | EPUB
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Article
Risdiplam: an investigational survival motor neuron 2 (SMN2) splicing modifier for spinal muscular atrophy (SMA)
Theodora Markati, Gemma Fisher, Sithara Ramdas & Laurent Servais
Pages: 451-461
Published online: 11 Apr 2022
AbstractforRisdiplam: an investigational survival motor neuron 2 (SMN2) splicing modifier for spinal muscular atrophy (SMA) | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Open Access

Review

Heart failure with preserved ejection fraction: key stumbling blocks for experimental drugs in clinical trials
Amanda Lloji, Jayakumar Sreenivasan, Joel Novograd, Wilbert S. Aronow, Stephen Pan & Gregg M. Lanier
Pages: 463-474
Published online: 27 Apr 2022
AbstractforHeart failure with preserved ejection fraction: key stumbling blocks for experimental drugs in clinical trials | Full Text | References | PDF (1.1 MB) | EPUB
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Repurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19: a critical discussion of recent publications
Jose Garrido-Mesa, Kate Adams, Julio Galvez & Natividad Garrido-Mesa
Pages: 475-482
Published online: 23 Mar 2022
AbstractforRepurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19: a critical discussion of recent publications | Full Text | References | PDF (3.1 MB) | EPUB
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Open Access

Perspective

Article
Why does survival of hepatocellular carcinoma patients remain so low? Key stumbling blocks and questions in preclinical and clinical development
Margherita Rimini, Nicole Liscia, Valentina Burgio & Andrea Casadei-Gardini
Pages: 483-494
Published online: 16 Mar 2022
AbstractforWhy does survival of hepatocellular carcinoma patients remain so low? Key stumbling blocks and questions in preclinical and clinical development | Full Text | References | PDF (873 KB) | EPUB
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