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Volume 31, Issue 9

Expert Opinion on Investigational Drugs

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Expert Opinion on Investigational Drugs, Volume 31, Issue 9 (2022)

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Expert Opinion on Investigational Drugs, Volume 31, Issue 9 (2022)

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Vol 33, 2024 Vol 32, 2023 Volume 31, 2022 Vol 30, 2021 Vol 29, 2020 Vol 28, 2019 Vol 27, 2018 Vol 26, 2017 Vol 25, 2016 Vol 24, 2015 Vol 23, 2014 Vol 22, 2013 Vol 21, 2012 Vol 20, 2011 Vol 19, 2010 Vol 18, 2009 Vol 17, 2008 Vol 16, 2007 Vol 15, 2006 Vol 14, 2005 Vol 13, 2004 Vol 12, 2003 Vol 11, 2002 Vol 10, 2001 Vol 9, 2000 Vol 8, 1999 Vol 7, 1998 Vol 6, 1997 Vol 5, 1996 Vol 4, 1995 Vol 3, 1994

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Editorial

CD200AR-L: mechanism of action and preclinical and clinical insights for treating high-grade brain tumors

Christopher Moertel, Francisco Martinez-Puerta, Grace G. Elizabeth Pluhar, Maria Graciela Castro & Michael Olin

Pages: 875-879

Published online: 03 Aug 2022

First Page PreviewforCD200AR-L: mechanism of action and preclinical and clinical insights for treating high-grade brain tumors | Full Text | References | PDF (2.4 MB) | EPUB

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Editorial

Pure red cell aplasia after hematopoietic stem cell transplantation - experimental therapeutic approaches

Anh Khoi Vo, Tor Hervig & Håkon Reikvam

Pages: 881-884

Published online: 12 Sep 2022

First Page PreviewforPure red cell aplasia after hematopoietic stem cell transplantation - experimental therapeutic approaches | Full Text | References | PDF (752.8 KB) | EPUB

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Free Access

Perspective

Article

Immune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development

Mario Rienzo, Tomasz Skirecki, Guillaume Monneret & Jean-François Timsit

Pages: 885-894

Published online: 18 Aug 2022

AbstractforImmune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development | Full Text | References | PDF (827.1 KB) | EPUB

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Review

Investigational drugs for the treatment of thymic cancer: a focus on phase 1 and 2 clinical trials

Fabio Conforti, Laura Pala, Tommaso De Pas, Yongfeng He & Giuseppe Giaccone

Pages: 895-904

Published online: 19 Aug 2022

AbstractforInvestigational drugs for the treatment of thymic cancer: a focus on phase 1 and 2 clinical trials | Full Text | References | PDF (365 KB) | EPUB

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Review

Hepatitis D virus (HDV): investigational therapeutic agents in clinical trials

Bilal Asif & Christopher Koh

Pages: 905-920

Published online: 01 Oct 2021

AbstractforHepatitis D virus (HDV): investigational therapeutic agents in clinical trials | Full Text | References | PDF (2.5 MB) | EPUB

401 Views
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Review

Giant cell arteritis: what is new in the preclinical and early clinical development pipeline?

Patricia Harkins & Richard Conway

Pages: 921-932

Published online: 30 Jun 2021

AbstractforGiant cell arteritis: what is new in the preclinical and early clinical development pipeline? | Full Text | References | PDF (1.8 MB) | EPUB

437 Views
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Review

Cyclin-dependent kinase inhibition and its intersection with immunotherapy in breast cancer: more than CDK4/6 inhibition

Xianan Guo, Huihui Chen, Yunxiang Zhou, Lu Shen, Shijie Wu & Yiding Chen

Pages: 933-944

Published online: 07 Jul 2022

AbstractforCyclin-dependent kinase inhibition and its intersection with immunotherapy in breast cancer: more than CDK4/6 inhibition | Full Text | References | PDF (907.2 KB) | EPUB

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Systematic Review

Investigational drugs for the treatment of olfactory dysfunction

Arianna Di Stadio, Cinzia Severini, Andrea Colizza, Marco De Vincentiis & Ignazio La Mantia

Pages: 945-955

Published online: 19 Aug 2022

AbstractforInvestigational drugs for the treatment of olfactory dysfunction | Full Text | References | PDF (2.3 MB) | EPUB

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Meta-Analysis

Dipeptidyl peptidase 4-inhibitor treatment was associated with a reduced incidence of neoplasm in patients with type 2 diabetes: a meta-analysis of 115 randomized controlled trials with 121961 participants

Zonglin Li, Chu Lin, Jinyu Zhou, Xiaoling Cai, Xingyun Zhu, Suiyuan Hu, Fang Lv, Wenjia Yang & Linong Ji

Pages: 957-964

Published online: 22 Aug 2022

AbstractforDipeptidyl peptidase 4-inhibitor treatment was associated with a reduced incidence of neoplasm in patients with type 2 diabetes: a meta-analysis of 115 randomized controlled trials with 121961 participants | Full Text | References | PDF (507.1 KB) | EPUB | Supplemental

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Original Research

Article

A randomized, adaptive design, double-blind, 3-arm, parallel study assessing the pharmacokinetics and safety of AVT02, a high-concentration (100 mg/mL) Adalimumab biosimilar, in healthy adult subjects (ALVOPAD FIRST)

Christopher Wynne, Christian Schwabe, Charlotte Lemech, Heimo Stroissnig, Roshan Dias, Joanna Sobierska, Eric Guenzi, Hendrik Otto, Abid Sattar, Richard Kay, Halimu N. Haliduola & Fausto Berti

Pages: 965-976

Published online: 10 Feb 2022

AbstractforA randomized, adaptive design, double-blind, 3-arm, parallel study assessing the pharmacokinetics and safety of AVT02, a high-concentration (100 mg/mL) Adalimumab biosimilar, in healthy adult subjects (ALVOPAD FIRST) | Full Text | References | PDF (749.9 KB) | EPUB | Supplemental

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Open Access

Article

A randomized, double-blind, placebo-controlled, single, and multiple dose-escalation Phase I clinical trial to investigate the safety, pharmacokinetic, and pharmacodynamic profiles of oral S086, a novel angiotensin receptor-neprilysin inhibitor, in healthy Chinese volunteers

Yue Hu, Hong Zhang, Xiaojiao Li, Jiajia Mai, Lizhi Yang, Jie Yan, Ying Li, Jingchao Sun, Wenjie Xu, Shiying He, Jinfeng Li & Min Wu

Pages: 977-985

Published online: 08 Nov 2021

AbstractforA randomized, double-blind, placebo-controlled, single, and multiple dose-escalation Phase I clinical trial to investigate the safety, pharmacokinetic, and pharmacodynamic profiles of oral S086, a novel angiotensin receptor-neprilysin inhibitor, in healthy Chinese volunteers | Full Text | References | PDF (884.5 KB) | EPUB

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