Expert Opinion on Drug Metabolism & Toxicology, Volume 2, Issue 1 (2006)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 2, Issue 1 (2006)

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Review

Article
Contribution of CYP2C9 to variability in vitamin K antagonist metabolism
Ann K Daly & Barry P King
Pages: 3-15
Published online: 01 Feb 2006
AbstractforContribution of CYP2C9 to variability in vitamin K antagonist metabolism | Full Text | References | PDF (143.3 KB)
  • 111 Views
  • 11 CrossRef citations
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Article
The role of drug-metabolising enzymes in clinical responses to chemotherapy
Charity D Scripture, William D Figg & Alex Sparreboom
Pages: 17-25
Published online: 01 Feb 2006
AbstractforThe role of drug-metabolising enzymes in clinical responses to chemotherapy | Full Text | References | PDF (102.1 KB)
  • 81 Views
  • 5 CrossRef citations
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Article
Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery
David C Lamb, F Peter Guengerich, Steven L Kelly & Michael R Waterman
Pages: 27-40
Published online: 01 Feb 2006
AbstractforExploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery | Full Text | References | PDF (195.6 KB)
  • 282 Views
  • 34 CrossRef citations
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Article
Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3
Ronald N Hines
Pages: 41-49
Published online: 01 Feb 2006
AbstractforDevelopmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3 | Full Text | References | PDF (122.6 KB)
  • 237 Views
  • 34 CrossRef citations
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Article
Active transport across the human placenta: impact on drug efficacy and toxicity
Denis Evseenko, James W Paxton & Jeffrey A Keelan
Pages: 51-69
Published online: 01 Feb 2006
AbstractforActive transport across the human placenta: impact on drug efficacy and toxicity | Full Text | References | PDF (248.2 KB)
  • 644 Views
  • 67 CrossRef citations
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Article
Mitochondria: new drug targets for oxidative stress-induced diseases
M W Anders, James L Robotham & Shey-Shing Sheu
Pages: 71-79
Published online: 01 Feb 2006
AbstractforMitochondria: new drug targets for oxidative stress-induced diseases | Full Text | References | PDF (121 KB)
  • 196 Views
  • 17 CrossRef citations
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Article
Molecular mechanisms for drug interactions with hERG that cause long QT syndrome
Phillip J Stansfeld, Michael J Sutcliffe & John S Mitcheson
Pages: 81-94
Published online: 01 Feb 2006
AbstractforMolecular mechanisms for drug interactions with hERG that cause long QT syndrome | Full Text | References | PDF (227.6 KB)
  • 333 Views
  • 37 CrossRef citations
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Article
Genomic-based biomarkers of drug-induced nephrotoxicity
John W Davis & Jeffrey A Kramer
Pages: 95-101
Published online: 01 Feb 2006
AbstractforGenomic-based biomarkers of drug-induced nephrotoxicity | Full Text | References | PDF (85.1 KB)
  • 154 Views
  • 24 CrossRef citations
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Article
A perspective on quantitative structure–activity relationships and carbonic anhydrase inhibitors
Brian W Clare & Claudiu T Supuran
Pages: 113-137
Published online: 01 Feb 2006
AbstractforA perspective on quantitative structure–activity relationships and carbonic anhydrase inhibitors | Full Text | References | PDF (572 KB)
  • 125 Views
  • 31 CrossRef citations
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Article
High-throughput pKa screening and prediction amenable for ADME profiling
Hong Wan & Johan Ulander
Pages: 139-155
Published online: 01 Feb 2006
AbstractforHigh-throughput pKa screening and prediction amenable for ADME profiling | Full Text | References | PDF (229.8 KB)
  • 405 Views
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Technology Evaluation

Article
A flexible approach for optimising in silico ADME/Tox characterisation of lead candidates
Yann Bidault
Pages: 157-168
Published online: 01 Feb 2006
AbstractforA flexible approach for optimising in silico ADME/Tox characterisation of lead candidates | Full Text | References | PDF (495.4 KB)
  • 94 Views
  • 7 CrossRef citations
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Editorial

Article
Commentary on variability in vitamin K antagonist metabolism
Dennis A Smith
Pages: 1-2
Published online: 01 Feb 2006
CitationforCommentary on variability in vitamin K antagonist metabolism | Full Text | References | PDF (27.7 KB)
  • 26 Views
  • 1 CrossRef citations
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Review

Article
Two-dimensional gels for toxicological drug discovery applications
Frank A Witzmann & Matthew R Richardson
Pages: 103-111
Published online: 01 Feb 2006
AbstractforTwo-dimensional gels for toxicological drug discovery applications | Full Text | References | PDF (109.3 KB)
  • 77 Views
  • 7 CrossRef citations
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