Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 1 (2012)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 1 (2012)

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Original Research

Article
Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers
Gopal Krishna PhD, Lei Ma, Pratapa Prasad, Allen Moton, Monika Martinho & Edward O'Mara
Pages: 1-10
Published online: 19 Dec 2011
AbstractforEffect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers | Full Text | References | PDF (411.1 KB)
  • 780 Views
  • 32 CrossRef citations
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Reviews

Review Article
Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation
Jochem Louisse, Miriam Verwei, Ruud A Woutersen, Bas J Blaauboer & Ivonne MCM Rietjens
Pages: 11-27
Published online: 25 Nov 2011
AbstractforToward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation | Full Text | References | PDF (491.8 KB)
  • 529 Views
  • 25 CrossRef citations
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Review Article
Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics
Olivier Fardel PharmD PhD, Elise Kolasa & Marc Le Vee
Pages: 29-46
Published online: 19 Dec 2011
AbstractforEnvironmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics | Full Text | References | PDF (435.1 KB)
  • 592 Views
  • 49 CrossRef citations
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Review Article
Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems
Arati Sharma, SubbaRao V Madhunapantula & Gavin P Robertson
Pages: 47-69
Published online: 19 Nov 2011
AbstractforToxicological considerations when creating nanoparticle-based drugs and drug delivery systems | Full Text | References | PDF (441.6 KB)
  • 745 Views
  • 141 CrossRef citations
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Review Article
Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders
Josef Finsterer (University Professor) MD PhD & Sinda Zarrouk Mahjoub PhD
Pages: 71-79
Published online: 07 Dec 2011
AbstractforMitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders | Full Text | References | PDF (208.7 KB)
  • 1493 Views
  • 83 CrossRef citations
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Review Article
Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects
Slobodan M Jankovic MD DSc MSc & Milivoje Dostic
Pages: 81-91
Published online: 19 Dec 2011
AbstractforChoice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects | Full Text | References | PDF (217.3 KB)
  • 1345 Views
  • 24 CrossRef citations
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Review Article
How is sesamin metabolised in the human liver to show its biological effects?
Kaori Yasuda (Researcher) & Toshiyuki Sakaki (Professor)
Pages: 93-102
Published online: 19 Nov 2011
AbstractforHow is sesamin metabolised in the human liver to show its biological effects? | Full Text | References | PDF (378.7 KB)
  • 294 Views
  • 18 CrossRef citations
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Drug Evaluations

Article
Clinical and pharmacokinetic evaluation of satraplatin
Gury Doshi MD, Guru Sonpavde MD & Cora N Sternberg MD FACP
Pages: 103-111
Published online: 19 Nov 2011
AbstractforClinical and pharmacokinetic evaluation of satraplatin | Full Text | References | PDF (258.5 KB)
  • 296 Views
  • 29 CrossRef citations
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Article
Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma
Angela Cioffi & Antoine Italiano MD PhD
Pages: 113-122
Published online: 19 Dec 2011
AbstractforClinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma | Full Text | References | PDF (264.5 KB)
  • 221 Views
  • 3 CrossRef citations
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Article
Deferasirox: pharmacokinetics and clinical experience
Renzo Galanello, Simona Campus & Raffaella Origa
Pages: 123-134
Published online: 19 Dec 2011
AbstractforDeferasirox: pharmacokinetics and clinical experience | Full Text | References | PDF (360.6 KB)
  • 863 Views
  • 23 CrossRef citations
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