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Volume 20, Issue 4

Expert Opinion on Therapeutic Targets

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Expert Opinion on Therapeutic Targets, Volume 20, Issue 4 (2016)

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Expert Opinion on Therapeutic Targets, Volume 20, Issue 4 (2016)

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Editorial

Accelerating Medicines Partnership: Alzheimer’s Disease (AMP-AD) Knowledge Portal Aids Alzheimer’s Drug Discovery through Open Data Sharing

Richard J. Hodes & Neil Buckholtz

Pages: 389-391

Published online: 07 Feb 2016

First Page PreviewforAccelerating Medicines Partnership: Alzheimer’s Disease (AMP-AD) Knowledge Portal Aids Alzheimer’s Drug Discovery through Open Data Sharing | Full Text | References | PDF (246.7 KB)

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Original Research

Article

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

Laura Garros-Regulez, Paula Aldaz, Olatz Arrizabalaga, Veronica Moncho-Amor, Estefania Carrasco-Garcia, Lorea Manterola, Leire Moreno-Cugnon, Cristina Barrena, Jorge Villanua, Irune Ruiz, Steven Pollard, Robin Lovell-Badge, Nicolas Sampron, Idoia Garcia & Ander Matheu

Pages: 393-405

Published online: 23 Feb 2016

AbstractformTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance | Full Text | References | PDF (1.6 MB) | Supplemental

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Open Access

Reviews

Review

Stem cell transcription factor NANOG in cancers – is eternal youth a curse?

Oscar GW Wong & Annie NY Cheung

Pages: 407-417

Published online: 04 Dec 2015

AbstractforStem cell transcription factor NANOG in cancers – is eternal youth a curse? | Full Text | References | PDF (944.1 KB)

428 Views
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Review

Targeting the Wnt signaling pathway in colorectal cancer

Masaaki Sawa (Chief Scientific Officer) PhD, Mari Masuda (Senior Scientist) PhD & Tesshi Yamada (Chief and Chair) MD PhD

Pages: 419-429

Published online: 06 Oct 2015

AbstractforTargeting the Wnt signaling pathway in colorectal cancer | Full Text | References | PDF (1.1 MB)

1465 Views
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Reviews

Review

The multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease

Ravichandran Ramasamy, Alexander Shekhtman & Ann Marie Schmidt

Pages: 431-446

Published online: 11 Nov 2015

AbstractforThe multiple faces of RAGE – opportunities for therapeutic intervention in aging and chronic disease | Full Text | References | PDF (684.6 KB)

838 Views
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Review

Lactoperoxidase as a potential drug target

Jörg Flemmig, Jana Gau, Denise Schlorke & Jürgen Arnhold

Pages: 447-461

Published online: 11 Nov 2015

AbstractforLactoperoxidase as a potential drug target | Full Text | References | PDF (829.7 KB)

311 Views
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Review

Therapeutic targets for cholestatic liver injury

Benjamin L. Woolbright & Hartmut Jaeschke

Pages: 463-475

Published online: 19 Oct 2015

AbstractforTherapeutic targets for cholestatic liver injury | Full Text | References | PDF (546.7 KB)

433 Views
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Review

The diverse oncogenic and tumor suppressor roles of salt-inducible kinase (SIK) in cancer

Wen-Qi Du, Jun-Nian Zheng & Dong-Sheng Pei

Pages: 477-485

Published online: 07 Nov 2015

AbstractforThe diverse oncogenic and tumor suppressor roles of salt-inducible kinase (SIK) in cancer | Full Text | References | PDF (434.7 KB)

1285 Views
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Review

Targeting autophagy and mitophagy for mitochondrial diseases treatment

Marina Villanueva Paz, David Cotán, Juan Garrido-Maraver, Mario D. Cordero, Manuel Oropesa-Ávila, Mario de La Mata, Ana Delgado Pavón, Isabel de Lavera, Elizabet Alcocer-Gómez & José A. Sánchez-Alcázar

Pages: 487-500

Published online: 02 Nov 2015

AbstractforTargeting autophagy and mitophagy for mitochondrial diseases treatment | Full Text | References | PDF (631.2 KB)

1174 Views
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Review

Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function

Ágnes Telbisz & László Homolya

Pages: 501-514

Published online: 17 Nov 2015

AbstractforRecent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function | Full Text | References | PDF (553.9 KB)

677 Views
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