Future Medicinal Chemistry, Volume 8, Issue 18 (2016)

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Future Medicinal Chemistry, Volume 8, Issue 18 (2016)

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Editorial

Editorial
Target Identification and Lead Discovery by Functional Lipidomics
Andreas Koeberle
Pages: 2169-2171
Published online: 15 Nov 2016
First Page PreviewforTarget Identification and Lead Discovery by Functional Lipidomics | Full Text | References | PDF (911.5 KB)
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Free Access
Editorial
Drug–Target Interaction Kinetics: Underutilized in Drug Optimization?
Robert A Copeland
Pages: 2173-2175
Published online: 15 Nov 2016
First Page PreviewforDrug–Target Interaction Kinetics: Underutilized in Drug Optimization? | Full Text | References | PDF (978.5 KB)
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Commentary

Editorial
Hsp70: Therapeutic Potential in Acute and Chronic Cardiac Disease Settings
Bianca C Bernardo, Kate L Weeks, Natalie L Patterson & Julie R McMullen
Pages: 2177-2183
Published online: 15 Nov 2016
AbstractforHsp70: Therapeutic Potential in Acute and Chronic Cardiac Disease Settings | Full Text | References | PDF (1.2 MB)
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Short Communication

Brief Report
Design of Chalcogen-Containing Norepinephrines: Efficient Gpx Mimics and Strong Cytotoxic Agents Against Hela Cells
Azucena Marset, Paloma Begines, Óscar López, Inés Maya, Natalia García-Aranda, Simó Schwartz Jr, Ibane Abasolo & José G Fernández-Bolaños
Pages: 2185-2195
Published online: 15 Nov 2016
AbstractforDesign of Chalcogen-Containing Norepinephrines: Efficient Gpx Mimics and Strong Cytotoxic Agents Against Hela Cells | Full Text | References | PDF (1.1 MB) | Supplemental
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Preliminary Communication

Brief Report
Design and Synthesis of a New Series of Highly Potent Raf Kinase-Inhibiting Triarylpyrazole Derivatives Possessing Antiproliferative Activity Against Melanoma Cells
Mohammad Ashrafuddin Khan, Mohammed I El-Gamal, Hamadeh Tarazi, Hong Seok Choi & Chang-Hyun Oh
Pages: 2197-2211
Published online: 15 Nov 2016
AbstractforDesign and Synthesis of a New Series of Highly Potent Raf Kinase-Inhibiting Triarylpyrazole Derivatives Possessing Antiproliferative Activity Against Melanoma Cells | Full Text | References | PDF (2.2 MB)
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Research Article

Article
N-Heterocyclic Carbene Complexes of Silver and Gold as Novel Tools Against Breast Cancer Progression
Carmela Saturnino, Ines Barone, Domenico Iacopetta, Annaluisa Mariconda, Maria Stefania Sinicropi, Camillo Rosano, Antonella Campana, Stefania Catalano, Pasquale Longo & Sebastiano Andò
Pages: 2213-2229
Published online: 22 Nov 2016
AbstractforN-Heterocyclic Carbene Complexes of Silver and Gold as Novel Tools Against Breast Cancer Progression | Full Text | References | PDF (2.1 MB)
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Article
Anti-Inflammatory Effect of Novel Analogs of Natural Enkephalinase Inhibitors in a Mouse Model of Experimental Colitis
Elżbieta Kamysz, Maciej Sałaga, Małgorzata Sobocińska, Artur Giełdoń & Jakub Fichna
Pages: 2231-2243
Published online: 15 Nov 2016
AbstractforAnti-Inflammatory Effect of Novel Analogs of Natural Enkephalinase Inhibitors in a Mouse Model of Experimental Colitis | Full Text | References | PDF (3.2 MB) | Supplemental
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Review

Review Article
Zwitterionic Structures: From Physicochemical Properties Toward Computer-Aided Drug Designs
Zhiwei Yang, Qinyi Li & Gang Yang
Pages: 2245-2262
Published online: 22 Nov 2016
AbstractforZwitterionic Structures: From Physicochemical Properties Toward Computer-Aided Drug Designs | Full Text | References | PDF (3.1 MB)
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Review Article
A Survey of the Mechanisms of Action of Anticancer Transition Metal Complexes
Mickaël Marloye, Gilles Berger, Michel Gelbcke & François Dufrasne
Pages: 2263-2286
Published online: 22 Nov 2016
AbstractforA Survey of the Mechanisms of Action of Anticancer Transition Metal Complexes | Full Text | References | PDF (1.6 MB)
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Review Article
Modern Tools for the Chemical Ligation and Synthesis of Modified Peptides and Proteins
Luca Gentilucci, Pierluigi Tosi, Adriano Bauer & Rossella De Marco
Pages: 2287-2304
Published online: 22 Nov 2016
AbstractforModern Tools for the Chemical Ligation and Synthesis of Modified Peptides and Proteins | Full Text | References | PDF (1.6 MB)
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Review Article
Structure–Activity Relationship Studies for Multitarget Antithrombotic Drugs
Ana R Neves, Marta Correia-da-Silva, Emília Sousa & Madalena Pinto
Pages: 2305-2355
Published online: 15 Nov 2016
AbstractforStructure–Activity Relationship Studies for Multitarget Antithrombotic Drugs | Full Text | References | PDF (3.5 MB)
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