Leukemia & Lymphoma, Volume 60, Issue 4 (2019)

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Leukemia & Lymphoma, Volume 60, Issue 4 (2019)

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Commentary

Article Commentary
New tools of the trade: parsing out the role of radiotherapy for early-stage diffuse large B-cell lymphoma
Yolanda D. Tseng, Andrea K. Ng & Andrew Wirth
Pages: 861-863
Published online: 27 Nov 2018
First Page PreviewforNew tools of the trade: parsing out the role of radiotherapy for early-stage diffuse large B-cell lymphoma | Full Text | References | PDF (300.4 KB) | EPUB
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Article Commentary
Immunotherapy in mycosis fungoides: opening night or dress rehearsal?
Niloufer Khan & Steven Horwitz
Pages: 864-866
Published online: 11 Jan 2019
First Page PreviewforImmunotherapy in mycosis fungoides: opening night or dress rehearsal? | Full Text | References | PDF (300.5 KB) | EPUB
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Review

Review
Oxidative stress in chronic lymphocytic leukemia: still a matter of debate
Giovanni D’Arena, Elisa Seneca, Ilaria Migliaccio, Vincenzo De Feo, Aldo Giudice, Francesco La Rocca, Mario Capunzo, Gioacchino Calapai, Agostino Festa, Michele Caraglia, Pellegrino Musto, Eugenio Luigi Iorio & Vitalba Ruggieri
Pages: 867-875
Published online: 20 Sep 2018
AbstractforOxidative stress in chronic lymphocytic leukemia: still a matter of debate | Full Text | References | PDF (1.1 MB) | EPUB
  • 384 Views
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Review
Mesenchymal stem cells in myeloproliferative disorders – focus on primary myelofibrosis
Sonia Emilia Selicean, Ciprian Tomuleasa, Ravnit Grewal, Graca Almeida-Porada & Ioana Berindan-Neagoe
Pages: 876-885
Published online: 02 Oct 2018
AbstractforMesenchymal stem cells in myeloproliferative disorders – focus on primary myelofibrosis | Full Text | References | PDF (1.4 MB) | EPUB
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Original Article: Clinical

Article
Radiotherapy for early stage diffuse large B-cell lymphoma with or without double or triple hit genetic alterations
George Daniel Grass, Matthew N. Mills, Kamran A. Ahmed, Casey L. Liveringhouse, Michael J. Montejo, Timothy J. Robinson, Julio C. Chavez, Louis B. Harrison & Sungjune Kim
Pages: 886-893
Published online: 20 Nov 2018
AbstractforRadiotherapy for early stage diffuse large B-cell lymphoma with or without double or triple hit genetic alterations | Full Text | References | PDF (781.5 KB) | EPUB | Supplemental
  • 377 Views
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Original Article: Research

Article
Obinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study
Jeff P. Sharman, Andres Forero-Torres, Luciano J. Costa, Ian W. Flinn, Lowell Inhorn, Kevin Kelly, Alberto Bessudo, Luis E. Fayad, Mark S. Kaminski, Andrew M. Evens, Christopher R. Flowers, Deniz Sahin, Kirsten E. Mundt, Thomas Sandmann, Günter Fingerle-Rowson, Charlotte Vignal, Mehrdad Mobasher & Andrew D. Zelenetz
Pages: 894-903
Published online: 02 Oct 2018
AbstractforObinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Open Access

Original Article: Clinical

Article
A phase II study of a modified hyper-CVAD frontline therapy for patients with adverse risk diffuse large B-cell and peripheral T-cell non-Hodgkin lymphoma
Greg Hapgood, Janey M. Stone, Diana Zannino, Anup George, Paula Marlton, Henry Miles Prince, Chi-Hung Hui, Ian Prosser, Ian D. Lewis, Kenneth Bradstock, John F. Seymour & On behalf of the Australasian Leukaemia and Lymphoma Group
Pages: 904-911
Published online: 14 Dec 2018
AbstractforA phase II study of a modified hyper-CVAD frontline therapy for patients with adverse risk diffuse large B-cell and peripheral T-cell non-Hodgkin lymphoma | Full Text | References | PDF (793.2 KB) | EPUB | Supplemental
  • 514 Views
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Article
A phase I study of romidepsin, gemcitabine, dexamethasone and cisplatin combination therapy in the treatment of peripheral T-cell and diffuse large B-cell lymphoma; the Canadian cancer trials group LY.15 study†
Tony Reiman, Kerry J. Savage, Michael Crump, Matthew C. Cheung, David MacDonald, Rena Buckstein, Stephen Couban, Eugenia Piliotis, Kevin Imrie, David Spaner, Sudeep Shivakumar, John Kuruvilla, Diego Villa, Lois E. Shepherd, Tanya Skamene, Chad Winch, Bingshu E. Chen & Annette E. Hay
Pages: 912-919
Published online: 10 Oct 2018
AbstractforA phase I study of romidepsin, gemcitabine, dexamethasone and cisplatin combination therapy in the treatment of peripheral T-cell and diffuse large B-cell lymphoma; the Canadian cancer trials group LY.15 study† | Full Text | References | PDF (867.6 KB) | EPUB | Supplemental
  • 417 Views
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Article
Cryptococcus neoformans infections in patients with lymphoproliferative neoplasms
Maria V. Dioverti, Sameer A. Parikh, Douglas R. Osmon, Thomas M. Habermann & Aaron J. Tande
Pages: 920-926
Published online: 06 Sep 2018
AbstractforCryptococcus neoformans infections in patients with lymphoproliferative neoplasms | Full Text | References | PDF (633.3 KB) | EPUB
  • 252 Views
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Article
The incidence of bleomycin induced lung toxicity is increased in Hodgkin lymphoma patients over 45 years exposed to granulocyte-colony stimulating growth factor
Maja D. Andersen, Peter Kamper, Alexander d’Amore, Michael Clausen, Hans Bentzen & Francesco d'Amore
Pages: 927-933
Published online: 02 Oct 2018
AbstractforThe incidence of bleomycin induced lung toxicity is increased in Hodgkin lymphoma patients over 45 years exposed to granulocyte-colony stimulating growth factor | Full Text | References | PDF (715 KB) | EPUB | Supplemental
  • 635 Views
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Article
The size and depth of lesions measured by endoscopic ultrasonography are novel prognostic factors of primary gastric diffuse large B-cell lymphoma
Yi-Zhen Liu, Kai Xue, Bo-Shi Wang, Chun-Yan Li, Fang-Fang Lv, Jia Jin, Qun-Ling Zhang, Zu-Guang Xia, Dong-Mei Ji, Hui Sun, Jia-Chen Wang, Xiao-Jian Liu, Jun-Ning Cao & Xiao-Nan Hong
Pages: 934-939
Published online: 02 Oct 2018
AbstractforThe size and depth of lesions measured by endoscopic ultrasonography are novel prognostic factors of primary gastric diffuse large B-cell lymphoma | Full Text | References | PDF (834.2 KB) | EPUB
  • 178 Views
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Article
Efficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin
Talha Badar, Mehdi Hamadani, Veronika Bachanova, Kami J. Maddocks, Elvira Umyarova, Julio C. Chavez, Narendranath Epperla, Saurabh Chhabra, Ana C. Xavier, Reem Karmali, Mohammed Salhab, Nishitha Reddy, Martha J. Glenn, Francisco J. Hernandez-Ilizaliturri, Christopher R. Flowers, Andrew M Evens, Zheng Zhou, Frederick Lansigan, Stefan K. Barta, Jonathon B Cohen, Timothy S. Fenske & Luciano J. Costa
Pages: 940-946
Published online: 02 Oct 2018
AbstractforEfficacy of salvage chemotherapy in diffuse large B cell lymphoma with primary treatment failure according to putative cell of origin | Full Text | References | PDF (875.5 KB) | EPUB
  • 431 Views
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Original Article: Research

Article
Treatment patterns, health care resource utilization, and costs in patients with relapsed/refractory Hodgkin lymphoma treated with brentuximab vedotin
Changxia Shao, Jinan Liu, Wei Zhou, Monika K. Raut, Matthew Monberg, Xiting Cao, Alejandro D. Ricart & Arun Balakumaran
Pages: 947-954
Published online: 20 Sep 2018
AbstractforTreatment patterns, health care resource utilization, and costs in patients with relapsed/refractory Hodgkin lymphoma treated with brentuximab vedotin | Full Text | References | PDF (887.9 KB) | EPUB | Supplemental
  • 1657 Views
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Open Access

Articles

Article
Adverse events, resource use, and economic burden associated with mantle cell lymphoma: a real-world assessment of privately insured patients in the United States
Ravi K. Goyal, Saurabh P. Nagar, Shaum M. Kabadi, James A. Kaye, Brian Seal & Anthony R. Mato
Pages: 955-963
Published online: 02 Oct 2018
AbstractforAdverse events, resource use, and economic burden associated with mantle cell lymphoma: a real-world assessment of privately insured patients in the United States | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 444 Views
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Original Article: Clinical

Article
Carfilzomib-based combination regimens are highly effective frontline therapies for multiple myeloma and Waldenström’s macroglobulinemia
Maria Chaudhry, Raphael Steiner, Catherine Claussen, Krina Patel, Hans Lee, Donna Weber, Sheeba Thomas, Chun Feng, Behrang Amini, Robert Orlowski, Lei Feng & Elisabet E. Manasanch
Pages: 964-970
Published online: 19 Sep 2018
AbstractforCarfilzomib-based combination regimens are highly effective frontline therapies for multiple myeloma and Waldenström’s macroglobulinemia | Full Text | References | PDF (663.9 KB) | EPUB
  • 483 Views
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Original Article: Research

Article
Descriptive analysis of genetic aberrations and cell of origin in Richter transformation
Ami Chitalia, David M. Swoboda, Justine N. McCutcheon, Metin Ozdemirli, Nadia Khan & Bruce D. Cheson
Pages: 971-979
Published online: 11 Jan 2019
AbstractforDescriptive analysis of genetic aberrations and cell of origin in Richter transformation | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 394 Views
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Article
A phase 2 study of lenalidomide and dexamethasone in previously untreated patients with chronic lymphocytic leukemia (CLL)
Christine I. Chen, Harminder Paul, Susi Snitzler, Sumeet Kakar, Lisa W. Le, Ellen N. Wei, Anthea Lau, James B. Johnston, Spencer B. Gibson, Michelle Queau, David Spaner, Danielle Croucher, Barbara Sherry & Suzanne Trudel
Pages: 980-989
Published online: 02 Oct 2018
AbstractforA phase 2 study of lenalidomide and dexamethasone in previously untreated patients with chronic lymphocytic leukemia (CLL) | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 380 Views
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Original Article: Clinical

Article
Elderly acute lymphoblastic leukemia: a Mayo Clinic study of 124 patients
Kevin C. Miller, Aref Al-Kali, Mithun V. Shah, William J. Hogan, Michelle A. Elliott, Kebede H. Begna, Naseema Gangat, Mrinal M. Patnaik, David S. Viswanatha, Rong He, Patricia T. Greipp, Lisa Z. Sproat, James M. Foran, Mark R. Litzow & Hassan B. Alkhateeb
Pages: 990-999
Published online: 02 Oct 2018
AbstractforElderly acute lymphoblastic leukemia: a Mayo Clinic study of 124 patients | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 495 Views
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Original Article: Research

Article
Characterizing the kinetics of lymphocytosis in patients with chronic lymphocytic leukemia treated with single-agent ibrutinib
Jacqueline C. Barrientos, Jan A. Burger, John C. Byrd, Peter Hillmen, Cathy Zhou, Joi Ninomoto, Danelle F. James & Thomas J. Kipps
Pages: 1000-1005
Published online: 02 Oct 2018
AbstractforCharacterizing the kinetics of lymphocytosis in patients with chronic lymphocytic leukemia treated with single-agent ibrutinib | Full Text | References | PDF (786.8 KB) | EPUB | Supplemental
  • 6040 Views
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Open Access

Original Article: Clinical

Article
Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study
Virginia Knez, Xin Liu, Jeffrey Schowinsky, Zenggang Pan, Dehua Wang, Robert Lorsbach, Chuanyi Lu, Catherine Luedke, Mary Haag, Billie Carstens, Karen Swisshelm, Lian-He Yang, Rachel Jug, Endi Wang & Xiayuan Liang
Pages: 1006-1013
Published online: 06 Sep 2018
AbstractforClinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study | Full Text | References | PDF (1.2 MB) | EPUB
  • 301 Views
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Article
FLAG salvage therapy combined with idarubicin in relapsed/refractory acute myeloid leukemia
Jonas Westhus, Richard Noppeney, Ulrich Dührsen & Maher Hanoun
Pages: 1014-1022
Published online: 02 Oct 2018
AbstractforFLAG salvage therapy combined with idarubicin in relapsed/refractory acute myeloid leukemia | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 889 Views
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Article
A comparison of patients with acute myeloid leukemia and high-risk myelodysplastic syndrome treated on versus off study
Sarah A. Buckley, Mary-Elizabeth Percival, Megan Othus, Anna B. Halpern, Emily M. Huebner, Pamela S. Becker, Carole Shaw, Mazyar Shadman, Roland B. Walter & Elihu H. Estey
Pages: 1023-1029
Published online: 02 Oct 2018
AbstractforA comparison of patients with acute myeloid leukemia and high-risk myelodysplastic syndrome treated on versus off study | Full Text | References | PDF (756 KB) | EPUB | Supplemental
  • 223 Views
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Article
An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens
Marta Sobas, Pau Montesinos, Blanca Boluda, Teresa Bernal, Edo Vellenga, Josep Nomdedeu, Jose González-Campos, Maria Chillón, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José David González-Sanmiguel, Cristina Gil-Cortes, Mar Tormo, Olga Salamero, Felix Manso, Isolda Fernández, Javier de la Serna, María-José Moreno, Manuel Pérez-Encinas, Isabel Krsnik, Josep-Maria Ribera, Lourdes Escoda, Bob Lowenberg, Miguel Angel Sanz & On behalf of the PETHEMA, HOVON, PALG, and GATLA cooperative groups
Pages: 1030-1035
Published online: 15 Oct 2018
AbstractforAn analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens | Full Text | References | PDF (966.4 KB) | EPUB
  • 266 Views
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Original Article: Research

Article
Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis
Kamal Menghrajani, Philip S. Boonstra, Jessica A. Mercer, Cecelia Perkins, Krisstina L. Gowin, Alissa A. Weber, Ruben Mesa, Jason R. Gotlib, Lixia Wang, Jack W. Singer & Moshe Talpaz
Pages: 1036-1042
Published online: 20 Sep 2018
AbstractforPredictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis | Full Text | References | PDF (648 KB) | EPUB | Supplemental
  • 262 Views
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Article
Characterization of two new high-grade B-cell lymphoma cell lines with MYC and BCL2 rearrangements that are suitable for in vitro drug sensitivity studies
Marie-Sophie Dheur, Hélène A. Poirel, Geneviève Ameye, Gaëlle Tilman, Pascale Saussoy, Jean-Philippe Defour, Alessandra Camboni, Eric Van Den Neste, Pierre G. Coulie & Nicolas van Baren
Pages: 1043-1052
Published online: 02 Oct 2018
AbstractforCharacterization of two new high-grade B-cell lymphoma cell lines with MYC and BCL2 rearrangements that are suitable for in vitro drug sensitivity studies | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 211 Views
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Article
Monozygotic twins with shared de novo GATA2 mutation but dissimilar phenotypes due to differential promoter methylation
Namhee Kim, Seongmin Choi, Sung-Min Kim, Amos Chungwon Lee, Kyongok Im, Hee Sue Park, Jung-Ah Kim, Kwangsoo Kim, Inho Kim, Yoon Hwan Chang & Dong Soon Lee
Pages: 1053-1061
Published online: 04 Feb 2019
AbstractforMonozygotic twins with shared de novo GATA2 mutation but dissimilar phenotypes due to differential promoter methylation | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 518 Views
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Article
Cytotoxic effect caspase activation dependent of a genetically engineered fusion protein with a CD154 peptide mimetic (OmpC-CD154p) on B-NHL cell lines is mediated by the inhibition of bcl-6 and YY1 through MAPK p38 activation
Gerardo Pantoja-Escobar, Mario Morales-Martínez, Gabriel G. Vega, Graciela Castro-Escarpulli & Mario I. Vega
Pages: 1062-1070
Published online: 02 Oct 2018
AbstractforCytotoxic effect caspase activation dependent of a genetically engineered fusion protein with a CD154 peptide mimetic (OmpC-CD154p) on B-NHL cell lines is mediated by the inhibition of bcl-6 and YY1 through MAPK p38 activation | Full Text | References | PDF (2.3 MB) | EPUB
  • 124 Views
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Article
Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients
Xue Chen, Fang Wang, Yang Zhang, Mangju Wang, Wenjun Tian, Wen Teng, Xiaoli Ma, Lei Guo, Jiancheng Fang, Ying Zhang, Ping Zhu & Hongxing Liu
Pages: 1071-1078
Published online: 02 Oct 2018
AbstractforPanoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 406 Views
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Letter to the Editor

Letter
Response to pembrolizumab and lenalidomide in advanced refractory mycosis fungoides
Eric Fountain, Haleigh Mistry, Preetesh Jain, Madeleine Duvic & Nathan Fowler
Pages: 1079-1082
Published online: 10 Oct 2018
First Page PreviewforResponse to pembrolizumab and lenalidomide in advanced refractory mycosis fungoides | Full Text | References | PDF (920.8 KB) | EPUB
  • 354 Views
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Letter
Monozygotic twins with non-Down syndrome associated MLL-rearranged hematologic malignancy and megakaryoblastic differentiation
Jennifer H. Foster, Chris L. Williams, Mohamed Tarek Elghetany, Pengfei Liu, Robert A. Krance, Alison A. Bertuch & Maria Monica Gramatges
Pages: 1083-1086
Published online: 02 Oct 2018
First Page PreviewforMonozygotic twins with non-Down syndrome associated MLL-rearranged hematologic malignancy and megakaryoblastic differentiation | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 131 Views
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Letter
Using the Lymph2Cx assay for assessing cell-of-origin subtypes of HIV-related diffuse large B-cell lymphoma
Maria Joao Baptista, Gustavo Tapia, Mireia Morgades, Josep Muncunill, Ana-María Muñoz-Marmol, Silvia Montoto, John G. Gribben, Maria Calaminici, Antonio Martinez, Blanca Gonzalez-Farre, Ivan Dlouhy, Eva González-Barca, María-José Terol, Pilar Miralles, Miguel Alcoceba, Ferran Vall-Llovera, Javier Briones, Pau Abrisqueta, Eugenia Abella, Mariano Provencio, Carlos García-Ballesteros, José-María Moraleda, Juan-Manuel Sancho, Josep-Maria Ribera, José-Luis Mate & José-Tomas Navarro
Pages: 1087-1091
Published online: 15 Oct 2018
First Page PreviewforUsing the Lymph2Cx assay for assessing cell-of-origin subtypes of HIV-related diffuse large B-cell lymphoma | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 236 Views
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Letter
Two cases of reversible Fanconi syndrome induced by lenalidomide
Nadège Wesner, Kevin Bihan, Alexandre Cez, Laurence Simon, Michel Biour, Damien Roos-Weil & Marine Baron
Pages: 1092-1094
Published online: 02 Oct 2018
First Page PreviewforTwo cases of reversible Fanconi syndrome induced by lenalidomide | Full Text | References | PDF (296.1 KB) | EPUB | Supplemental
  • 227 Views
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Letter
The power of the partner: defying expectations in a case of a myeloproliferative neoplasm with FGFR1 rearrangement
Adam C. Wilberger, Brandon McMahon & Mark D. Ewalt
Pages: 1095-1097
Published online: 02 Oct 2018
First Page PreviewforThe power of the partner: defying expectations in a case of a myeloproliferative neoplasm with FGFR1 rearrangement | Full Text | References | PDF (652.1 KB) | EPUB
  • 154 Views
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Letter
Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia
Margaret Nieborowska-Skorska, Silvia Maifrede, Min Ye, Monika Toma, Elizabeth Hewlett, John Gordon, Bac Viet Le, Tomasz Sliwinski, Huaqing Zhao, Katarzyna Piwocka, Peter Valent, Alexei V. Tulin, Wayne Childers & Tomasz Skorski
Pages: 1098-1101
Published online: 02 Oct 2018
First Page PreviewforNon-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia | Full Text | References | PDF (631 KB) | EPUB | Supplemental
  • 439 Views
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Letter
Real world experience with “generic” pomalidomide in relapsed refractory multiple myeloma
Aditya Jandial, Kundan Mishra, Deepesh Lad, Gaurav Prakash, Alka Khadwal & Pankaj Malhotra
Pages: 1102-1104
Published online: 15 Oct 2018
First Page PreviewforReal world experience with “generic” pomalidomide in relapsed refractory multiple myeloma | Full Text | References | PDF (451.4 KB) | EPUB
  • 406 Views
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Letter
Pomalidomide – Author Reply
Ashleigh P. Scott & Peter Mollee
Page: 1105
Published online: 02 Oct 2018
CitationforPomalidomide – Author Reply | Full Text | References | PDF (279.3 KB) | EPUB
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