Xenobiotica, Volume 38, Issue 4 (2008)

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Xenobiotica, Volume 38, Issue 4 (2008)

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Research Article

Article
Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines
D. Hallifax, A. Galetin & J. B. Houston
Pages: 353-367
Published online: 22 Sep 2008
AbstractforPrediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines | Full Text | References | PDF (124.2 KB)
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Article
In vivo approach for the evaluation of mechanism-based inhibition of cytochrome P450 3A in rats
N. Sekiguchi, M. Kato, M. Takada, H. Watanabe, A. Higashida, S. Sakai, M. Ishigai & Y. Aso
Pages: 368-381
Published online: 22 Sep 2008
AbstractforIn vivo approach for the evaluation of mechanism-based inhibition of cytochrome P450 3A in rats | Full Text | References | PDF (99.8 KB)
  • 169 Views
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Article
Pharmacokinetic characterization of hydroxylpropyl-β-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza)
Y. Pan, H.-C. Bi, G.-P. Zhong, X. Chen, Z. Zuo, L.-Z. Zhao, L.-Q. Gu, P.-Q. Liu, Z.-Y. Huang, S.-F. Zhou & M. Huang
Pages: 382-398
Published online: 22 Sep 2008
AbstractforPharmacokinetic characterization of hydroxylpropyl-β-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza) | Full Text | References | PDF (141.2 KB)
  • 247 Views
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Article
Disposition and metabolism of the colchicine derivative [14C]-ZD6126 in rat and dog
E. A. Partridge, R. A. D'souza, E. M. Lenz, S. M. Smith, J. Clarkson-Jones & D. W. Roberts
Pages: 399-421
Published online: 22 Sep 2008
AbstractforDisposition and metabolism of the colchicine derivative [14C]-ZD6126 in rat and dog | Full Text | References | PDF (470.3 KB)
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Article
Dietary salt does not influence the disposition of verapamil enantiomers in relation to efflux transporter ABCB1 genetic polymorphism in healthy Korean subjects
W. Pan, J. Y. Ryu, J. H. Shon, I. S. Song, K. H. Liu, Y. E. Sunwoo, W. Kang & J. G. Shin
Pages: 422-434
Published online: 22 Sep 2008
AbstractforDietary salt does not influence the disposition of verapamil enantiomers in relation to efflux transporter ABCB1 genetic polymorphism in healthy Korean subjects | Full Text | References | PDF (391.1 KB)
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Article
Effect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats
N. N. Patel, C. M. Crincoli, E. L. Kennedy, D. M. Frederick, R. Tchao & P. J. Harvison
Pages: 435-449
Published online: 22 Sep 2008
AbstractforEffect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats | Full Text | References | PDF (730.6 KB)
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