Xenobiotica, Volume 39, Issue 11 (2009)

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Xenobiotica, Volume 39, Issue 11 (2009)

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Research Article

Article
Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes
K. Murai, H. Yamazaki, K. Nakagawa, R. Kawai & T. Kamataki
Pages: 795-802
Published online: 21 Oct 2009
AbstractforDeactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes | Full Text | References | PDF (725.8 KB)
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Article
In vitro model for the prediction of clinical CYP3A4 induction using HepaRG cells
A. Kaneko, M. Kato, N. Sekiguchi, T. Mitsui, K. Takeda & Y. Aso
Pages: 803-810
Published online: 21 Oct 2009
AbstractforIn vitro model for the prediction of clinical CYP3A4 induction using HepaRG cells | Full Text | References | PDF (853.4 KB)
  • 646 Views
  • 20 CrossRef citations
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Article
Metabolite screening of aromatic amine hair dyes using in vitro hepatic models
J. A. Skare, N. J. Hewitt, E. Doyle, R. Powrie & C. Elcombe
Pages: 811-825
Published online: 21 Oct 2009
AbstractforMetabolite screening of aromatic amine hair dyes using in vitro hepatic models | Full Text | References | PDF (1.3 MB)
  • 198 Views
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Article
Studies on induction of lamotrigine metabolism in transgenic UGT1 mice
U. A. Argikar, K. Senekeo-Effenberger, E. E. Larson, R. H. Tukey & R. P. Remmel
Pages: 826-835
Published online: 21 Oct 2009
AbstractforStudies on induction of lamotrigine metabolism in transgenic UGT1 mice | Full Text | References | PDF (740.6 KB)
  • 240 Views
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Article
Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel
Y. Nishiya, K. Hagihara, A. Kurihara, N. Okudaira, N.A. Farid, O. Okazaki & T. Ikeda
Pages: 836-843
Published online: 21 Oct 2009
AbstractforComparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel | Full Text | References | PDF (948.4 KB)
  • 528 Views
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Article
Effect of bifendate on the pharmacokinetics of talinolol in healthy subjects
Y. Zeng, F.-Y. He, Y.-J. He, L.-L. Dai, L. Fan & H.-H. Zhou
Pages: 844-849
Published online: 21 Oct 2009
AbstractforEffect of bifendate on the pharmacokinetics of talinolol in healthy subjects | Full Text | References | PDF (622.9 KB)
  • 121 Views
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Article
Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor
H. Wong, J.Z. Chen, B. Chou, J.S. Halladay, J.R. Kenny, H. La, J.C. Marsters Jr, E. Plise, P.J. Rudewicz, K. Robarge, Y. Shin, S. Wong, C. Zhang & S.C. Khojasteh
Pages: 850-861
Published online: 21 Oct 2009
AbstractforPreclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor | Full Text | References | PDF (1 MB)
  • 1037 Views
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Article
Pharmacokinetics and anti-inflammatory pharmacodynamics of prednisolone in cynomolgus monkey
Y.J. Zheng, M. Hawk, H. Yuan, H.R. Hope, M. Baratta & A. Zutshi
Pages: 862-870
Published online: 21 Oct 2009
AbstractforPharmacokinetics and anti-inflammatory pharmacodynamics of prednisolone in cynomolgus monkey | Full Text | References | PDF (949 KB)
  • 369 Views
  • 3 CrossRef citations
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Article
Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice
J. Kuze, T. Mutoh, T. Takenaka, K. Morisaki, H. Nakura, N. Hanioka & S. Narimatsu
Pages: 871-880
Published online: 21 Oct 2009
AbstractforSeparate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice | Full Text | References | PDF (855.5 KB)
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