Xenobiotica, Volume 40, Issue 6 (2010)

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Xenobiotica, Volume 40, Issue 6 (2010)

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General Xenobiochemistry

Article
Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor
H. Eng, M. Niosi, T. S. McDonald, A. Wolford, Y. Chen, S. T. M. Simila, J. N. Bauman, J. Warmus & A. S. Kalgutkar
Pages: 369-380
Published online: 18 Mar 2010
AbstractforUtility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor | Full Text | References | PDF (851.9 KB)
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Article
Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism
N. Al Koudsi & R. F. Tyndale
Pages: 381-392
Published online: 22 Mar 2010
AbstractforHepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism | Full Text | References | PDF (830.7 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes
J.-H. Tu, D.-L. Hu, L.-L. Dai, Y. Sun, L. Fan, M. Zhang, Z.-R. Tan, Y. Chen, Z. Li & H.-H. Zhou
Pages: 393-399
Published online: 29 Mar 2010
AbstractforEffect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes | Full Text | References | PDF (708.3 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism, pharmacokinetics and excretion of the GABAA receptor partial agonist [14C]CP-409,092 in rats
A. Kamel, R. S. Obach, E. Tseng & A. Sawant
Pages: 400-414
Published online: 24 Mar 2010
AbstractforMetabolism, pharmacokinetics and excretion of the GABAA receptor partial agonist [14C]CP-409,092 in rats | Full Text | References | PDF (865.3 KB)
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Article
Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey
D. J. Sweeny, W. Li, E. Grossbard & D. T.W. Lau
Pages: 415-423
Published online: 23 Apr 2010
AbstractforContribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey | Full Text | References | PDF (1.3 MB)
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Article
Pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl4
H.E. Kang, Y.W. Kim, S.I. Sohn, S.R. Baek, J.W. Lee, S.G. Kim, I. Lee & M.G. Lee
Pages: 424-436
Published online: 29 Mar 2010
AbstractforPharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats with acute hepatitis induced by d-galactosamine/lipopolysaccharide or CCl4 | Full Text | References | PDF (749.2 KB)
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Article
The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS
Mark de Serres, Lee Moss, James Sigafoos, Andrea Sefler, Stephen Castellino, Gary Bowers & Cosette Serabjit-Singh
Pages: 437-445
Published online: 12 Apr 2010
AbstractforThe disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS | Full Text | References | PDF (685.2 KB)
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