Xenobiotica, Volume 41, Issue 1 (2011)

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Xenobiotica, Volume 41, Issue 1 (2011)

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General Xenobiochemistry

Article
CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity
Hege Christensen, Anette L. Hestad, Espen Molden & Liv Mathiesen
Pages: 1-5
Published online: 18 Oct 2010
AbstractforCYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity | Full Text | References | PDF (610 KB)
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Article
In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol
Fagen Zhang, Ezra R. Lowe, David.L. Rick, Xiaohua Qiu, E. Leibold, George Cruzan & Michael J. Bartels
Pages: 6-23
Published online: 07 Oct 2010
AbstractforIn vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol | Full Text | References | PDF (1.5 MB)
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Article
Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
Min-Koo Choi, Ho Jung Shin, Young-Lim Choi, Jian-Wei Deng, Jae-Gook Shin & Im-Sook Song
Pages: 24-34
Published online: 15 Oct 2010
AbstractforDifferential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors | Full Text | References | PDF (996 KB)
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Article
3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties
Jing Zhu, Yueqing Hu, Maurice K.C. Ho & Yung H. Wong
Pages: 35-45
Published online: 26 Nov 2010
Abstractfor3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic properties | Full Text | References | PDF (843.7 KB)
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Article
Characterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine
Ling Ye, Lan Tang, Yun Gong, Chang Lv, Zhijie Zheng, Zhihong Jiang & Zhongqiu Liu
Pages: 46-58
Published online: 24 Nov 2010
AbstractforCharacterization of metabolites and human P450 isoforms involved in the microsomal metabolism of mesaconitine | Full Text | References | PDF (1,022.7 KB)
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Article
Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone
Jelle Reinen, Livia L. Kalma, Selina Begheijn, Ferry Heus, Jan N.M. Commandeur & Nico P.E. Vermeulen
Pages: 59-70
Published online: 18 Nov 2010
AbstractforApplication of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone | Full Text | References | PDF (993.5 KB)
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Article
Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers
W. H. Jing, Y. L. Song, R. Yan, H. C. Bi, P. T. Li & Y. T. Wang
Pages: 71-81
Published online: 27 Oct 2010
AbstractforTransport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers | Full Text | References | PDF (1 MB)
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Animal Pharmacokinetics and Metabolism

Article
An interspecies extrapolation of the pharmacokinetics of telavancin, a rapidly bactericidal, concentration-dependent antibiotic
Jeng-Pyng Shaw & Sarah Jaw-Tsai
Pages: 82-89
Published online: 15 Oct 2010
AbstractforAn interspecies extrapolation of the pharmacokinetics of telavancin, a rapidly bactericidal, concentration-dependent antibiotic | Full Text | References | PDF (716 KB)
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