Xenobiotica, Volume 41, Issue 4 (2011)

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Xenobiotica, Volume 41, Issue 4 (2011)

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General Xenobiochemistry

Article
Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study
Ya-He Liu, Sui-Lin Mo, Hui-Chang Bi, Bing-Fang Hu, Chun Guang Li, Yi-Tao Wang, Ling Huang, Min Huang, Wei Duan, Jun-Ping Liu, Ming Qian Wei & Shu-Feng Zhou
Pages: 259-280
Published online: 30 Nov 2010
AbstractforRegulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study | Full Text | References | PDF (1.1 MB)
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Article
Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity
Harshica Fernando, Jessica A. O. Rumfeldt, Nadezhda Y. Davydova, James R. Halpert & Dmitri R. Davydov
Pages: 281-289
Published online: 14 Dec 2010
AbstractforMultiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity | Full Text | References | PDF (871.7 KB)
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Article
Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein
Xinfeng Zhang, Furong Qiu, Jian Jiang, Chenglu Gao & Yingzi Tan
Pages: 290-296
Published online: 14 Feb 2011
AbstractforIntestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein | Full Text | References | PDF (651.1 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers
Peter Stopfer, Karin Rathgen, Daniel Bischoff, Silke Lüdtke, Kristell Marzin, Rolf Kaiser, Klaus Wagner & Thomas Ebner
Pages: 297-311
Published online: 04 Jan 2011
AbstractforPharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers | Full Text | References | PDF (859.4 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats
Lian Zhou, Peggy Liu-Kreyche & Ramaswamy A. Iyer
Pages: 312-319
Published online: 14 Dec 2010
AbstractforMetabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats | Full Text | References | PDF (835.5 KB)
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Article
Interactions between the chemotherapeutic agent eribulin mesylate (E7389) and P-glycoprotein in CF-1 abcb1a-deficient mice and Caco-2 cells
Jan-Shiang Taur, Christopher S. DesJardins, Edgar L. Schuck & Y. Nancy Wong
Pages: 320-326
Published online: 17 Dec 2010
AbstractforInteractions between the chemotherapeutic agent eribulin mesylate (E7389) and P-glycoprotein in CF-1 abcb1a-deficient mice and Caco-2 cells | Full Text | References | PDF (673.8 KB)
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Article
Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic–pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor
Bianca M. Liederer, Leonid M. Berezhkovskiy, Brian J. Dean, Vikki Dinkel, Jing Peng, Mark Merchant, Emile G. Plise, Harvey Wong & Xingrong Liu
Pages: 327-339
Published online: 23 Dec 2010
AbstractforPreclinical absorption, distribution, metabolism, excretion, and pharmacokinetic–pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor | Full Text | References | PDF (796.5 KB)
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Article
Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats
Chao Zhang, Xiangyong Cui, Yan Yang, Feng Gao, Yantong Sun, Jingkai Gu, J. Paul Fawcett, Wei Yang & Wei Wang
Pages: 340-348
Published online: 23 Dec 2010
AbstractforPharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats | Full Text | References | PDF (853.5 KB)
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