Xenobiotica, Volume 42, Issue 10 (2012)

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Xenobiotica, Volume 42, Issue 10 (2012)

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General Xenobiochemistry

Article
Generation of proliferating human hepatocytes using upcyte® technology: characterisation and applications in induction and cytotoxicity assays
Alexandra Burkard, Caroline Dähn, Stefan Heinz, Anne Zutavern, Vera Sonntag-Buck, Daniel Maltman, Stefan Przyborski, Nicola J. Hewitt & Joris Braspenning
Pages: 939-956
Published online: 24 Apr 2012
AbstractforGeneration of proliferating human hepatocytes using upcyte® technology: characterisation and applications in induction and cytotoxicity assays | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist
Shin Takusagawa, Kanako Yajima, Aiji Miyashita, Shotaro Uehara, Takafumi Iwatsubo & Takashi Usui
Pages: 957-967
Published online: 18 Apr 2012
AbstractforIdentification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist | Full Text | References | PDF (759.8 KB) | Supplemental
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Article
Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers
Eliane Alexandre, Audrey Baze, Céline Parmentier, Coraline Desbans, Dumrongsak Pekthong, Brigitte Gerin, Claudine Wack, Philippe Bachellier, Bruno Heyd, Jean-Christophe Weber & Lysiane Richert
Pages: 968-979
Published online: 19 Apr 2012
AbstractforPlateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers | Full Text | References | PDF (1 MB)
  • 465 Views
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Article
Method for predicting human intestinal first-pass metabolism of UGT substrate compounds
Takako Furukawa, Katsuhiro Yamano, Yoichi Naritomi, Kohichiro Tanaka, Shigeyuki Terashita & Toshio Teramura
Pages: 980-988
Published online: 27 Apr 2012
AbstractforMethod for predicting human intestinal first-pass metabolism of UGT substrate compounds | Full Text | References | PDF (804.1 KB) | Supplemental
  • 605 Views
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Article
Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa
Roslyn S. Thelingwani, Kariema Dhansay, Peter Smith, Kelly Chibale & Collen M. Masimirembwa
Pages: 989-1000
Published online: 25 Apr 2012
AbstractforPotent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa | Full Text | References | PDF (1.2 MB)
  • 259 Views
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Article
Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
Liangliang Zhu, Guangbo Ge, Yong Liu, Guiyuan He, Sicheng Liang, Zhongze Fang, Peipei Dong, Yunfeng Cao & Ling Yang
Pages: 1001-1008
Published online: 16 May 2012
AbstractforPotent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9 | Full Text | References | PDF (903.8 KB)
  • 357 Views
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Article
Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol
Rui-Hua Dong, Zhong-Ze Fang, Liang-Liang Zhu, Guang-Bo Ge, Ling Yang & Ze-Yuan Liu
Pages: 1009-1016
Published online: 04 May 2012
AbstractforIdentification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol | Full Text | References | PDF (885.3 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily
Seung Yon Han, Insoo Yoon, Young-Won Chin, Il Whan Cho, Myung Gull Lee & Young Hee Choi
Pages: 1017-1027
Published online: 09 May 2012
AbstractforPharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily | Full Text | References | PDF (839.9 KB)
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Molecular Toxicology

Article
Reactions of benzene oxide, a reactive metabolite of benzene, with model nucleophiles and DNA
Kateřina Míčová & Igor Linhart
Pages: 1028-1037
Published online: 26 Mar 2012
AbstractforReactions of benzene oxide, a reactive metabolite of benzene, with model nucleophiles and DNA | Full Text | References | PDF (900.2 KB)
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Article
Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates
Hemlata Tamta, Rahul S. Pawar, Wayne G. Wamer, Erich Grundel, Alexander J. Krynitsky & Jeanne I. Rader
Pages: 1038-1048
Published online: 23 Apr 2012
AbstractforComparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates | Full Text | References | PDF (979.1 KB) | Supplemental
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