Xenobiotica, Volume 42, Issue 11 (2012)

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Xenobiotica, Volume 42, Issue 11 (2012)

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General Xenobiochemistry

Article
Reduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol s-methyltransferase in humans: an in vitro study
R. Scott Obach, Chandra Prakash & Amin M. Kamel
Pages: 1049-1057
Published online: 04 May 2012
AbstractforReduction and methylation of ziprasidone by glutathione, aldehyde oxidase, and thiol s-methyltransferase in humans: an in vitro study | Full Text | References | PDF (882.2 KB)
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Article
Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats
Ragini Vuppugalla, Yueping Zhang, Shu Chang, A. David Rodrigues & Punit H. Marathe
Pages: 1058-1068
Published online: 11 May 2012
AbstractforImpact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats | Full Text | References | PDF (856.4 KB)
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Article
Metabolism of ibuprofen in zebrafish larvae
Huw S. Jones, Henry T. Trollope, Thomas H. Hutchinson, Grace H. Panter & J. Kevin Chipman
Pages: 1069-1075
Published online: 17 May 2012
AbstractforMetabolism of ibuprofen in zebrafish larvae | Full Text | References | PDF (816.7 KB)
  • 673 Views
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Article
Stereoselective and regiospecific hydroxylation of ketamine and norketamine
Zeruesenay Desta, Ruin Moaddel, Evan T. Ogburn, Cong Xu, Anuradha Ramamoorthy, Swarajya Lakshmi Vattem Venkata, Mitesh Sanghvi, Michael E. Goldberg, Marc C. Torjman & Irving W. Wainer
Pages: 1076-1087
Published online: 21 May 2012
AbstractforStereoselective and regiospecific hydroxylation of ketamine and norketamine | Full Text | References | PDF (925.8 KB) | Supplemental
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Article
In vitro metabolism of piperaquine is primarily mediated by CYP3A4
Tina Ming-Na Lee, Liusheng Huang, Marla K. Johnson, Patricia Lizak, Deanna Kroetz, Francesca Aweeka & Sunil Parikh
Pages: 1088-1095
Published online: 06 Jun 2012
AbstractforIn vitro metabolism of piperaquine is primarily mediated by CYP3A4 | Full Text | References | PDF (1,015.9 KB)
  • 434 Views
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Article
Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues
Vanessa Zancanella, Mery Giantin, Rosa Maria Lopparelli, Carlo Nebbia & Mauro Dacasto
Pages: 1096-1109
Published online: 13 Jun 2012
AbstractforConstitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues | Full Text | References | PDF (903.1 KB)
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Animal Pharmacokinetics and Metabolism

Article
Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats
Insoo Yoon, Seungyon Han, Young-Hee Choi, Hee-Eun Kang, Hyun-Jong Cho, Jung Sun Kim, Chang-Koo Shim, Suk-Jae Chung, Saeho Chong & Dae-Duk Kim
Pages: 1110-1119
Published online: 02 Jul 2012
AbstractforSaturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats | Full Text | References | PDF (1.1 MB)
  • 225 Views
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Article
Isolation and identification of metabolites of osthole in rats
X. Lv, C.-Y. Wang, J. Hou, B.-J. Zhang, S. Deng, Y. Tian, S.-S. Huang, H.-L. Zhang, X.-H. Shu, Y.-H. Zhen, K.-X. Liu, J.-H. Yao & X.-C. Ma
Pages: 1120-1127
Published online: 26 May 2012
AbstractforIsolation and identification of metabolites of osthole in rats | Full Text | References | PDF (681.4 KB)
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Article
Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers
Kristin Samuelsson, Kathryn Pickup, Sunil Sarda, John G. Swales, Yoshio Morikawa, Timothy Schulz-Utermoehl, Michael Hutchison & Ian D. Wilson
Pages: 1128-1137
Published online: 30 May 2012
AbstractforPharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers | Full Text | References | PDF (764.2 KB)
  • 676 Views
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Article
Pharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats
Jing Zhu, Yueqing Hu, Maurice K. C Ho & Yung H. Wong
Pages: 1138-1150
Published online: 30 May 2012
AbstractforPharmacokinetics, oral bioavailability and metabolism of a novel isoquinolinone-based melatonin receptor agonist in rats | Full Text | References | PDF (894.2 KB)
  • 264 Views
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Article
Food–drug interactions: effect of capsaicin on the pharmacokinetics of galantamine in rats
Xue-jia Zhai & Yong-ning Lu
Pages: 1151-1155
Published online: 05 Jun 2012
AbstractforFood–drug interactions: effect of capsaicin on the pharmacokinetics of galantamine in rats | Full Text | References | PDF (868.5 KB)
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Pharmacogenetics

Article
Pharmacokinetics of lansoprazole and its main metabolites after single intravenous doses in healthy Chinese subjects
Dan Zhang, Man Yang, Man Liu, Yanan Zhang, Xiaolin Wang, Xue Xiao & Huichen Liu
Pages: 1156-1162
Published online: 21 May 2012
AbstractforPharmacokinetics of lansoprazole and its main metabolites after single intravenous doses in healthy Chinese subjects | Full Text | References | PDF (754.1 KB)
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