Xenobiotica, Volume 42, Issue 5 (2012)

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Xenobiotica, Volume 42, Issue 5 (2012)

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General Xenobiochemistry

Article
Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes
Shimin Zhang, Venkateswaran C. Pillai, Sripal Reddy Mada, Steve Strom & Raman Venkataramanan
Pages: 409-416
Published online: 22 Nov 2011
AbstractforEffect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes | Full Text | References | PDF (726.4 KB)
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Article
Use of primary rat hepatocytes in the gel entrapment culture to predict in vivo biliary excretion
Jian Yin & Qin Meng
Pages: 417-428
Published online: 22 Nov 2011
AbstractforUse of primary rat hepatocytes in the gel entrapment culture to predict in vivo biliary excretion | Full Text | References | PDF (1 MB)
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Article
A comparative in vitro kinetic study of [14C]-eugenol and [14C]-methyleugenol activation and detoxification in human, mouse, and rat liver and lung fractions
Emmanuel F. Minet, Gentile Daniela, Clive Meredith & Eian D. Massey
Pages: 429-441
Published online: 22 Dec 2011
AbstractforA comparative in vitro kinetic study of [14C]-eugenol and [14C]-methyleugenol activation and detoxification in human, mouse, and rat liver and lung fractions | Full Text | References | PDF (1.3 MB)
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Animal Pharmacokinetics and Metabolism

Article
Effects of cysteine on the pharmacokinetics of docetaxel in rats with protein–calorie malnutrition
Young Hee Choi, Insoo Yoon, Yoon Gyoon Kim & Myung Gull Lee
Pages: 442-455
Published online: 08 Nov 2011
AbstractforEffects of cysteine on the pharmacokinetics of docetaxel in rats with protein–calorie malnutrition | Full Text | References | PDF (966.7 KB)
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Article
Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors
Bianca M. Liederer, Xingrong Liu, Leonid M. Berezhkovskiy, Gary Cain, Xiao Ding, John Gaudino, Robert Kaus, Emile G. Plise, Daniel P. Sutherlin & Eric B. Harstad
Pages: 456-465
Published online: 28 Nov 2011
AbstractforPreclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors | Full Text | References | PDF (770.9 KB)
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Article
Rapid determination of isocorydine in rat plasma and tissues using liquid chromatography – tandem mass spectrometry and its applications to pharmacokinetics and tissue distribution
Changchuan Guo, Caihong Yu, Li Li, Yuqing Wang, Shengjia Wang, Weihong Wang, Haihong Hu, Siyun Xu, Lushan Yu, Huidi Jiang & Su Zeng
Pages: 466-476
Published online: 21 Feb 2012
AbstractforRapid determination of isocorydine in rat plasma and tissues using liquid chromatography – tandem mass spectrometry and its applications to pharmacokinetics and tissue distribution | Full Text | References | PDF (1 MB)
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Article
Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration
Silvia Wein, Rainer Cermak, Siegfried Wolffram & Peter Langguth
Pages: 477-482
Published online: 22 Dec 2011
AbstractforChronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration | Full Text | References | PDF (772.5 KB)
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Article
Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes
Young H. Choi & Myung G. Lee
Pages: 483-495
Published online: 14 Mar 2012
AbstractforPharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes | Full Text | References | PDF (812 KB)
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Pharmacogenetics

Article
Effects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin
Chang-Ik Choi, Yun-Jeong Lee, Hye-In Lee, Bo-Hye Kim, Mi-Jeong Kim, Choon-Gon Jang, Jung-Woo Bae & Seok-Yong Lee
Pages: 496-501
Published online: 11 Nov 2011
AbstractforEffects of the SLCO1B1*15 allele on the pharmacokinetics of pitavastatin | Full Text | References | PDF (800.3 KB)
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