Xenobiotica, Volume 42, Issue 7 (2012)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 42, Issue 7 (2012)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Volume 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
Eun-Young Kwak, Won-Sik Shim, Ji-Eun Chang, Saeho Chong, Dae-Duk Kim, Suk-Jae Chung & Chang-Koo Shim
Pages: 603-613
Published online: 10 Jan 2012
AbstractforEnhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters | Full Text | References | PDF (807.8 KB)
  • 507 Views
  • 25 CrossRef citations
  • 0Altmetric
Article
Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene
Takeshi Hori, Liangjing Jin, Ayako Fujii, Tomomi Furihata, Yuko Nagahara, Kan Chiba & Masakiyo Hosokawa
Pages: 614-623
Published online: 11 Jan 2012
AbstractforDexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene | Full Text | References | PDF (1 MB)
  • 208 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
Similarities in diesel exhaust particles induced alterations in expression of cytochrome P-450 and glutathione S-transferases in rat lymphocytes and lungs
Ankita Srivastava, Sanjay Yadav, Amit Sharma, UN Dwivedi, SJS Flora & Devendra Parmar
Pages: 624-632
Published online: 21 Feb 2012
AbstractforSimilarities in diesel exhaust particles induced alterations in expression of cytochrome P-450 and glutathione S-transferases in rat lymphocytes and lungs | Full Text | References | PDF (739.9 KB)
  • 102 Views
  • 10 CrossRef citations
  • 0Altmetric
Article
Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4
Masato Ohbuchi, Kiyoshi Noguchi, Akio Kawamura & Takashi Usui
Pages: 633-640
Published online: 07 Feb 2012
AbstractforDifferent effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4 | Full Text | References | PDF (681.5 KB) | Supplemental
  • 886 Views
  • 20 CrossRef citations
  • 0Altmetric
Article
Effects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats
Theerada Taesotikul, Miki Nakajima, Wichittra Tassaneeyakul & Tsuyoshi Yokoi
Pages: 641-648
Published online: 20 Feb 2012
AbstractforEffects of Phyllanthus amarus on the pharmacokinetics of midazolam and cytochrome P450 activities in rats | Full Text | References | PDF (729.5 KB)
  • 263 Views
  • 8 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals
Hiroshi Maeda, Hiroshi Kodaira, Kazuhiro Fujita, Hiroyuki Kobayashi, Junko Ushiki, Takeo Nakanishi & Ikumi Tamai
Pages: 649-659
Published online: 10 Feb 2012
AbstractforSpecies differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals | Full Text | References | PDF (1,023.5 KB)
  • 150 Views
  • 0 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats
Kathryn W. Woodburn, Christopher P. Holmes, Susan D. Wilson, Kei-Lai Fong, Randall J. Press, Yuu Moriya & Yoshihiko Tagawa
Pages: 660-670
Published online: 22 Dec 2011
AbstractforAbsorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats | Full Text | References | PDF (800.7 KB)
  • 2293 Views
  • 29 CrossRef citations
  • 0Altmetric
Open Access
Article
The utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P1 agonists
Simon Taylor, James R. J. Gray, Robert Willis, Nigel Deeks, Andrea Haynes, Colin Campbell, Pam Gaskin, Karen Leavens, Emmanuel Demont, Simon Dowell, Jenni Cryan, Mary Morse, Aarti Patel, Helen Garden & Jason Witherington
Pages: 671-686
Published online: 09 Jan 2012
AbstractforThe utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P1 agonists | Full Text | References | PDF (1 MB)
  • 797 Views
  • 10 CrossRef citations
  • 0Altmetric
Article
Metabolism and excretion of TH-302 in dogs
Donald Jung, Hailong Jiao, Jian-Xi Duan, Mark Matteucci & Ronghua Wang
Pages: 687-700
Published online: 21 Feb 2012
AbstractforMetabolism and excretion of TH-302 in dogs | Full Text | References | PDF (2.4 MB)
  • 277 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
Pre-clinical pharmacokinetics of the acridine antitumour candidate AC04 and its 1-oxo-metabolite plasma profile
Maiara Cássia Pigatto, Flávia De Toni Uchôa, Bruna Torres, Sandra Haas, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Norberto Peporine Lopes & Teresa Dalla Costa
Pages: 701-707
Published online: 07 Feb 2012
AbstractforPre-clinical pharmacokinetics of the acridine antitumour candidate AC04 and its 1-oxo-metabolite plasma profile | Full Text | References | PDF (698.3 KB)
  • 124 Views
  • 3 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao et al.
Review Article | Published online: 13 May 2024
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray et al.
Article | Published online: 13 May 2024
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang et al.
Review Article | Published online: 11 May 2024
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu et al.
Review Article | Published online: 30 Apr 2024
View all latest articles