Xenobiotica, Volume 43, Issue 10 (2013)

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Xenobiotica, Volume 43, Issue 10 (2013)

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General Xenobiochemistry

Article
Correlation-based prediction of tissue-to-plasma partition coefficients using readily available input parameters
Y. E. Yun & A. N. Edginton
Pages: 839-852
Published online: 19 Feb 2013
AbstractforCorrelation-based prediction of tissue-to-plasma partition coefficients using readily available input parameters | Full Text | References | PDF (268.8 KB)
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Research Article

Article
A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes
Tuomas Rahikainen, Merja R. Häkkinen, Moshe Finel, Markku Pasanen & Risto O. Juvonen
Pages: 853-861
Published online: 03 Apr 2013
AbstractforA high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes | Full Text | References | PDF (987.1 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects
Ling-Ling Dai, Lan Fan, Hui-Zi Wu, Zhi-Rong Tan, Yao Chen, Xiang-Dong Peng, Min-Xue Shen, Guo-Ping Yang & Hong-Hao Zhou
Pages: 862-867
Published online: 01 Mar 2013
AbstractforAssessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects | Full Text | References | PDF (246.6 KB)
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Animal Pharmacokinetics and Metabolism

Article
Simultaneous determination by LC-MS/MS of 25-methoxydammarane-3β,12β,20-triol epimers and active metabolites in rat plasma after intravenous administration
Cai-Hong Shi, Xiangrong Zhang, Hao Suo, Tian Yin, Haiyan Xu, Bo Yuan & Yuqing Zhao
Pages: 868-874
Published online: 30 Apr 2013
AbstractforSimultaneous determination by LC-MS/MS of 25-methoxydammarane-3β,12β,20-triol epimers and active metabolites in rat plasma after intravenous administration | Full Text | References | PDF (557.3 KB)
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Research Article

Article
The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway
Sherri Smith, Jennifer Hoyt, Nigel Whitebread, Joseph Manna, Marisa Peluso, Kerrie Faia, Veronica Campbell, Martin Tremblay, Somarajan Nair, Michael Grogan, Alfredo Castro, Matthew Campbell, Jeanne Ferguson, Brendan Arsenault, Jylle Nevejans, Bennett Carter, John Lee, Joi Dunbar, Karen McGovern, Margaret Read, Julian Adams, Alexander Constan, Gordon Loewen, Jens Sydor, Vito Palombella & John Soglia
Pages: 875-885
Published online: 25 Mar 2013
AbstractforThe pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway | Full Text | References | PDF (608 KB)
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Article
Comparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats
Zuzana Havlinova, Andrea Babicova, Milos Hroch & Jaroslav Chladek
Pages: 886-894
Published online: 21 Mar 2013
AbstractforComparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats | Full Text | References | PDF (592.6 KB)
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Article
Effect of food intake on the pharmacokinetics of sarpogrelate and its active metabolite following oral administration to beagle dogs
In-Hwan Baek, Byung-Yo Lee, Min-Soo Kim & Kwang-Il Kwon
Pages: 895-900
Published online: 28 Mar 2013
AbstractforEffect of food intake on the pharmacokinetics of sarpogrelate and its active metabolite following oral administration to beagle dogs | Full Text | References | PDF (502.3 KB)
  • 237 Views
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Article
Effects of 17α-ethynylestradiol-induced cholestasis on the pharmacokinetics of doxorubicin in rats: reduced biliary excretion and hepatic metabolism of doxorubicin
Young Hee Choi, Yu Kyung Lee & Myung Gull Lee
Pages: 901-907
Published online: 10 Apr 2013
AbstractforEffects of 17α-ethynylestradiol-induced cholestasis on the pharmacokinetics of doxorubicin in rats: reduced biliary excretion and hepatic metabolism of doxorubicin | Full Text | References | PDF (198 KB)
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Molecular Toxicology

Article
Injection of ropivacaine into the subarachnoid changes the ultrastructure and proteome of the rat spinal cord
Lin Li, Tiezheng Zhang, Yugang Diao & Junke Wang
Pages: 908-914
Published online: 28 Mar 2013
AbstractforInjection of ropivacaine into the subarachnoid changes the ultrastructure and proteome of the rat spinal cord | Full Text | References | PDF (1.3 MB)
  • 106 Views
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Xenobiotic Transporters

Article
A membrane vesicle-based assay to enable prediction of human biliary excretion
Federico Colombo, Hugo Poirier, Nathalie Rioux, Maria Arias Montecillo, Jianmin Duan & Maria D. Ribadeneira
Pages: 915-919
Published online: 12 Feb 2013
AbstractforA membrane vesicle-based assay to enable prediction of human biliary excretion | Full Text | References | PDF (278.5 KB)
  • 469 Views
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Research Article

Article
Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA
B. Williamson, A. C. Soars, A. Owen, P. White, R. J. Riley & M. G. Soars
Pages: 920-931
Published online: 06 Mar 2013
AbstractforDissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA | Full Text | References | PDF (682.9 KB)
  • 608 Views
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