Xenobiotica, Volume 43, Issue 2 (2013)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 43, Issue 2 (2013)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Volume 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms
Rui-Hua Dong, Zhong-Ze Fang, Liang-Liang Zhu, Guang-Bo Ge, Xiao-Bao Li, Cui-Min Hu, Yun-Feng Cao, Yang-Liu Xia, Ling Yang & Ze-Yuan Liu
Pages: 133-139
Published online: 20 Jul 2012
AbstractforDeep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms | Full Text | References | PDF (831.6 KB) | Supplemental
  • 200 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips
Régis Baudoin, Jean Matthieu Prot, Grégory Nicolas, Jessy Brocheton, Céline Brochot, Cécile Legallais, Henri Benech & Eric Leclerc
Pages: 140-152
Published online: 25 Jul 2012
AbstractforEvaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips | Full Text | References | PDF (1 MB)
  • 758 Views
  • 41 CrossRef citations
  • 0Altmetric
Article
Prediction of drug concentration-time profiles of therapeutic proteins in humans from animals
Iftekhar Mahmood
Pages: 153-160
Published online: 25 Jul 2012
AbstractforPrediction of drug concentration-time profiles of therapeutic proteins in humans from animals | Full Text | References | PDF (791 KB)
  • 363 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner
Alejandro Mejia-Garcia, Esmeralda M. Sanchez-Ocampo, Silvia Galindo-Gomez, Mineko Shibayama, Octavio Reyes-Hernandez, Simon Guzman-Leon, Frank J. Gonzalez & Guillermo Elizondo
Pages: 161-168
Published online: 27 Jul 2012
Abstractfor2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner | Full Text | References | PDF (985 KB)
  • 280 Views
  • 10 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application
James M. Mathews, Sherri S. Brown, Purvi R. Patel, Sherry R. Black, Troy T. Banks, Amy S. Etheridge, Timothy R. Fennell, Rodney W. Snyder, Chad R. Blystone & Suramya Waidyanatha
Pages: 169-181
Published online: 25 Jul 2012
AbstractforMetabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application | Full Text | References | PDF (830.6 KB)
  • 299 Views
  • 9 CrossRef citations
  • 0Altmetric
Article
Absorption of TAK-491, a new angiotensin II receptor antagonist, in animals
Naohiro Kawaguchi, Takuya Ebihara, Toshiyuki Takeuchi, Akio Morohashi, Hitomi Yamasaki, Yoshihiko Tagawa, Junzo Takahashi, Takahiro Kondo & Satoru Asahi
Pages: 182-192
Published online: 07 Aug 2012
AbstractforAbsorption of TAK-491, a new angiotensin II receptor antagonist, in animals | Full Text | References | PDF (755.9 KB)
  • 439 Views
  • 7 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug–drug interactions in humans
Kyeong-Ryoon Lee, Sung Heum Choi, Jin-Sook Song, Eun-Young Kwak, Yoon-Jee Chae, So Hee Im, Byung Hoi Lee, Hyewon Seo, Woon-Ki Cho, Min-Sun Kim, Nak Jeong Kim, Sung-Hoon Ahn & Myung Ae Bae
Pages: 193-200
Published online: 03 Aug 2012
AbstractforPharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug–drug interactions in humans | Full Text | References | PDF (718.1 KB)
  • 246 Views
  • 1 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
Metabolic profiling of TRPV1 antagonists of the benzothiazole amide series: implications for in vitro genotoxicity assessment
Johan Bylund, Carl Petersson, Anders Lindgren, Susanne Olofsson & Stefan Czene
Pages: 201-210
Published online: 07 Aug 2012
AbstractforMetabolic profiling of TRPV1 antagonists of the benzothiazole amide series: implications for in vitro genotoxicity assessment | Full Text | References | PDF (1,021.8 KB)
  • 294 Views
  • 6 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism
Wei Pan, Soo-Kyung Bae, Eon-Jeong Shim, Sung-Eun Park, Sang-Seop Lee, Soo-Jin Park, Chang-Woo Yeo, Hong-Hao Zhou, Ji-Hong Shon & Jae-Gook Shin
Pages: 211-218
Published online: 25 Jul 2012
AbstractforEffects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism | Full Text | References | PDF (683.1 KB) | Supplemental
  • 298 Views
  • 5 CrossRef citations
  • 0Altmetric

Topics in Xenobiochemistry

Article
Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary
Ronald E. White, David C. Evans, Cornelis E. C. A. Hop, David J. Moore, Chandra Prakash, Sekhar Surapaneni & Francis L. S. Tse
Pages: 219-225
Published online: 18 Jul 2012
AbstractforRadiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary | Full Text | References | PDF (606.2 KB)
  • 970 Views
  • 35 CrossRef citations
  • 0Altmetric
Article
A response to “radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary”
R. Scott Obach, Angus N. Nedderman & Dennis A. Smith
Pages: 226-227
Published online: 25 Jul 2012
CitationforA response to “radiolabelled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary” | Full Text | References | PDF (569.1 KB)
  • 491 Views
  • 6 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao et al.
Review Article | Published online: 13 May 2024
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray et al.
Article | Published online: 13 May 2024
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang et al.
Review Article | Published online: 11 May 2024
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu et al.
Review Article | Published online: 30 Apr 2024
View all latest articles