Xenobiotica, Volume 44, Issue 3 (2014)

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Xenobiotica, Volume 44, Issue 3 (2014)

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General Xenobiochemistry

Article
Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions
Ramakrishna Nirogi, Vishwottam Kandikere, Raghava Choudary Palacharla, Gopinadh Bhyrapuneni, Vijaya Bhargava Kanamarlapudi, Ranjith Kumar Ponnamaneni & Arun Kumar Manoharan
Pages: 197-204
Published online: 24 Oct 2013
AbstractforIdentification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions | Full Text | References | PDF (250.3 KB)
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Research Article

Article
Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys
Takako Furukawa, Yoichi Naritomi, Kazuhiro Tetsuka, Fumihiro Nakamori, Hiroyuki Moriguchi, Katsuhiro Yamano, Shigeyuki Terashita, Kenji Tabata & Toshio Teramura
Pages: 205-216
Published online: 20 Aug 2013
AbstractforSpecies differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys | Full Text | References | PDF (399.1 KB)
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Article
Impact of coexposure on toluene biomarkers in rats
Frédéric Cosnier, Hervé Nunge, Céline Brochard, Manuella Burgart, Aurélie Rémy, Marie-Josèphe Décret, Benoît Cossec & Pierre Campo
Pages: 217-228
Published online: 09 Sep 2013
AbstractforImpact of coexposure on toluene biomarkers in rats | Full Text | References | PDF (1.5 MB)
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Article
Contribution of cytochrome P450 isoforms to gliquidone metabolism in rats and human
Fang He, Yun Li, Caiwen Zeng, Chunhua Xia, Yuqing Xiong, Hong Zhang, Shibo Huang & Mingyi Liu
Pages: 229-234
Published online: 29 Aug 2013
AbstractforContribution of cytochrome P450 isoforms to gliquidone metabolism in rats and human | Full Text | References | PDF (445.2 KB)
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Article
Solvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and recommended solvent dose limits
Evan A. Thackaberry, Xiaojing Wang, Michelle Schweiger, Kirsten Messick, Nicole Valle, Brian Dean, Amy Sambrone, Terri Bowman & Minli Xie
Pages: 235-241
Published online: 18 Oct 2013
AbstractforSolvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and recommended solvent dose limits | Full Text | References | PDF (135.3 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans
Yoshinobu Nakamaru, Yoshiharu Hayashi, Ruriko Ikegawa, Shuji Kinoshita, Begonya Perez Madera, Dave Gunput, Atsuhiro Kawaguchi, Martin Davies, Stuart Mair, Hiroshi Yamazaki, Toshiyuki Kume & Masayuki Suzuki
Pages: 242-253
Published online: 15 Jul 2013
AbstractforMetabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans | Full Text | References | PDF (917.7 KB)
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Animal Pharmacokinetics and Metabolism

Article
Pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate LaSOM 65 in rats
Bruna G. S. Torres, Flávia De Toni Uchôa, Maiara C. Pigatto, Francine J. Azeredo, Sandra E. Haas, Eliane Dallegrave, Rômulo F. S. Canto, Vera L. Eifler-Lima & Teresa Dalla Costa
Pages: 254-263
Published online: 12 Aug 2013
AbstractforPre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate LaSOM 65 in rats | Full Text | References | PDF (278.1 KB)
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Research Article

Article
Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters
Qiuxia Gao, Robert E. Kimura, Xiping Zhang, Joon Nam, Benny M. Amore, Dean Hickman, J. Greg Slatter & Maurice G. Emery
Pages: 264-269
Published online: 21 Mar 2013
AbstractforIntestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters | Full Text | References | PDF (200.6 KB)
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Pharmacogenetics

Article
Effect of 36 CYP2C9 variants found in the Chinese population on losartan metabolism in vitro
Yu-Han Wang, Pei-Pei Pan, Da-Peng Dai, Shuang-Hu Wang, Pei-Wu Geng, Jian-Ping Cai & Guo-Xin Hu
Pages: 270-275
Published online: 11 Jul 2013
AbstractforEffect of 36 CYP2C9 variants found in the Chinese population on losartan metabolism in vitro | Full Text | References | PDF (450.3 KB)
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Xenobiotic Transporters

Article
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia
William J. Chiou, Sonia M. de Morais, Ryota Kikuchi, Richard L. Voorman, Xiaofeng Li & Daniel A. J. Bow
Pages: 276-282
Published online: 25 Jul 2013
AbstractforIn vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia | Full Text | References | PDF (385.4 KB) | Supplemental
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Research Article

Article
Re-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells
Jenni J. Hakkarainen, Kirsi Rilla, Marjukka Suhonen, Marika Ruponen & Markus M. Forsberg
Pages: 283-294
Published online: 07 Aug 2013
AbstractforRe-evaluation of the role of P-glycoprotein in in vitro drug permeability studies with the bovine brain microvessel endothelial cells | Full Text | References | PDF (1.8 MB)
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