Xenobiotica, Volume 44, Issue 7 (2014)

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Xenobiotica, Volume 44, Issue 7 (2014)

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General Xenobiochemistry

Article
Effect of triacontanol on the pharmacokinetics of docetaxel in rats associated with induction of cytochrome P450 3A1/2
Shuhua Deng, Chunfeng Wang, Wei Zhang, Wenchao Gao, Ali Fan, Qiuyang Zhang, Yongjie Zhang, Qingwang Liu, Ning Li, Qi Liu, Jie Zhao, Cuiyun Li, Xingyuan Wen, Di Zhao & Xijing Chen
Pages: 583-590
Published online: 13 Dec 2013
AbstractforEffect of triacontanol on the pharmacokinetics of docetaxel in rats associated with induction of cytochrome P450 3A1/2 | Full Text | References | PDF (594 KB)
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Research Article

Article
Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility
Amit S. Kalgutkar, Kosea S. Frederick, Heather L. Hatch, Catherine M. Ambler, David A. Perry, Ravi S. Garigipati, George C. Chang, Bruce A. Lefker, Ronald W. Clark, Lee A. Morehouse, Omar Francone & Xiao Hu
Pages: 591-605
Published online: 31 Dec 2013
AbstractforIdentification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility | Full Text | References | PDF (1 MB)
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Article
In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential
Faraz Kazmi, Lois J. Haupt, Jennifer R. Horkman, Brian D. Smith, David B. Buckley, Eric A. Wachter & Jamie M. Singer
Pages: 606-614
Published online: 10 Jan 2014
AbstractforIn vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential | Full Text | References | PDF (307.6 KB) | Supplemental
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Article
Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies
Therese Ericsson, Jesper Sundell, Angelica Torkelsson, Kurt-Jürgen Hoffmann & Michael Ashton
Pages: 615-626
Published online: 08 Jan 2014
AbstractforEffects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies | Full Text | References | PDF (723.5 KB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats
Yoon Kim, Unyong Kim, In Sook Kim, Sung-Hack Lee, Jaeick Lee, Dong-Hyun Kim & Hye Hyun Yoo
Pages: 627-634
Published online: 16 Apr 2014
AbstractforAbsorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats | Full Text | References | PDF (444.8 KB) | Supplemental
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Research Article

Article
Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats
Ji Won Jung, Ju Myung Kim, Jin Seok Jeong, Miwon Son, Hye Suk Lee, Myung Gull Lee & Hee Eun Kang
Pages: 635-643
Published online: 13 Jan 2014
AbstractforPharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats | Full Text | References | PDF (284.2 KB)
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Article
Species and sex-dependent toxicokinetics of 1-bromopropane: the role of hepatic cytochrome P450 oxidation and glutathione (GSH)
C. Edwin Garner & X. Yu
Pages: 644-656
Published online: 17 Jan 2014
AbstractforSpecies and sex-dependent toxicokinetics of 1-bromopropane: the role of hepatic cytochrome P450 oxidation and glutathione (GSH) | Full Text | References | PDF (1.7 MB)
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Xenobiotic Transporters

Article
Application of an in vitro OAT assay in drug design and optimization of renal clearance
Matthew G. Soars, Patrick Barton, Lisa L. Elkin, Kathleen W. Mosure, Joanne L. Sproston & Robert J. Riley
Pages: 657-665
Published online: 13 Jan 2014
AbstractforApplication of an in vitro OAT assay in drug design and optimization of renal clearance | Full Text | References | PDF (330.3 KB)
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Topics in Xenobiochemistry

Review Article
Curiosities in drug metabolism
Stephen C. Mitchell, Rosemary H. Waring & Robert L. Smith
Pages: 666-676
Published online: 29 Apr 2014
AbstractforCuriosities in drug metabolism | Full Text | References | PDF (312.4 KB)
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