Xenobiotica, Volume 45, Issue 10 (2015)

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Xenobiotica, Volume 45, Issue 10 (2015)

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General Xenobiochemistry

Article
Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins
Andrew Rowland, David Hallifax, Matthew R. Nussio, Joseph G. Shapter, Peter I. Mackenzie, J. Brian Houston, Kathleen M. Knights & John O. Miners
Pages: 847-857
Published online: 24 Mar 2015
AbstractforCharacterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins | Full Text | References | PDF (648.7 KB)
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Article
Irreversible binding of an anticancer compound (BI-94) to plasma proteins
Nagsen Gautam, Rhishikesh Thakare, Sandeep Rana, Amarnath Natarajan & Yazen Alnouti
Pages: 858-873
Published online: 14 Apr 2015
AbstractforIrreversible binding of an anticancer compound (BI-94) to plasma proteins | Full Text | References | PDF (3.3 MB)
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Article
Decreased elimination clearance of midazolam by doxorubicin through reductions in the metabolic activity of hepatic CYP3A in rats
Katsuhito Nagai, Natsumi Yoshida, Maho Kiyama, Keita Kasahara, Ayumi Yamamura & Hiroki Konishi
Pages: 874-880
Published online: 08 Jun 2015
AbstractforDecreased elimination clearance of midazolam by doxorubicin through reductions in the metabolic activity of hepatic CYP3A in rats | Full Text | References | PDF (614.9 KB)
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Article
Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling
Satomi Shida, Masahiro Utoh, Norie Murayama, Makiko Shimizu, Yasuhiro Uno & Hiroshi Yamazaki
Pages: 881-886
Published online: 15 Jun 2015
AbstractforHuman plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling | Full Text | References | PDF (1.3 MB)
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Clinical Pharmacokinetics and Metabolism

Article
Human mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor
Kazuo Oda, Ying J. Cao, Taiji Sawamoto, Naoyuki Nakada, Ogert Fisniku, Yasuhisa Nagasaka & Kin-ya Sohda
Pages: 887-902
Published online: 19 May 2015
AbstractforHuman mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor | Full Text | References | PDF (2 MB)
  • 771 Views
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Animal Pharmacokinetics and Metabolism

Article
Distribution and pharmacokinetics of etamicastat and its N-acetylated metabolite (BIA 5-961) in dog and monkey
A. I. Loureiro & P. Soares-da-Silva
Pages: 903-911
Published online: 14 Apr 2015
AbstractforDistribution and pharmacokinetics of etamicastat and its N-acetylated metabolite (BIA 5-961) in dog and monkey | Full Text | References | PDF (600.8 KB)
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Article
Pharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats
Malgorzata Szafarz, Agata Kryczyk, Dorota Lazewska, Katarzyna Kiec-Kononowicz & Elzbieta Wyska
Pages: 912-920
Published online: 14 Apr 2015
AbstractforPharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats | Full Text | References | PDF (386.8 KB)
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Molecular Toxicology

Article
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells
Yuchao Xie, Mitchell R. McGill, Sarah F. Cook, Matthew R. Sharpe, Robert D. Winefield, Diana G. Wilkins, Douglas E. Rollins & Hartmut Jaeschke
Pages: 921-929
Published online: 14 Apr 2015
AbstractforTime course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells | Full Text | References | PDF (360.9 KB)
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Article
Modulation of aryl hydrocarbon receptor regulated genes by acute administration of trimethylarsine oxide in the lung, kidney and heart of C57BL/6 mice
Osama H. Elshenawy & Ayman O. S. El-Kadi
Pages: 930-943
Published online: 04 Jun 2015
AbstractforModulation of aryl hydrocarbon receptor regulated genes by acute administration of trimethylarsine oxide in the lung, kidney and heart of C57BL/6 mice | Full Text | References | PDF (945.2 KB)
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