Xenobiotica, Volume 45, Issue 1 (2015)

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Xenobiotica, Volume 45, Issue 1 (2015)

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Obituary

Obituary
In Memoriam Sybil Pauline James (9 February 1917 – 25 October 2014)
Stephen Mitchell & Rosemary Waring
Pages: 1-2
Published online: 05 Dec 2014
CitationforIn Memoriam Sybil Pauline James (9 February 1917 – 25 October 2014) | Full Text | PDF (226.7 KB)
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Research Article

Article
Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague–Dawley and Dark Agouti rats
Giovanni Licari, Andrew A. Somogyi, Robert W. Milne & Benedetta C. Sallustio
Pages: 3-9
Published online: 22 Jul 2014
AbstractforComparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague–Dawley and Dark Agouti rats | Full Text | References | PDF (795.9 KB)
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Article
Glucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3
Eun-Sook Jeong, Yang-Weon Kim, Hyo-Ji Kim, Ho-Jung Shin, Jae-Gook Shin, Kwang Hee Kim, Yong Ha Chi, Soo Heui Paik & Dong-Hyun Kim
Pages: 10-18
Published online: 18 Jul 2014
AbstractforGlucuronidation of fimasartan, a new angiotensin receptor antagonist, is mainly mediated by UGT1A3 | Full Text | References | PDF (568.1 KB)
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Article
Semi-physiological pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats
Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, Kanji Takada & Toshiyuki Sakaeda
Pages: 19-28
Published online: 22 Jul 2014
AbstractforSemi-physiological pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats | Full Text | References | PDF (661.9 KB)
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Article
Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device
Aurelie Vivares, Sandrine Salle-Lefort, Catherine Arabeyre-Fabre, Robert Ngo, Geraldine Penarier, Michele Bremond, Patricia Moliner, Jean-François Gallas, Gerard Fabre & Sylvie Klieber
Pages: 29-44
Published online: 28 Jul 2014
AbstractforMorphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device | Full Text | References | PDF (2.6 MB)
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Article
Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects
Theodore R. Johnson, Weiwei Tan, Lance Goulet, Evan B. Smith, Shinji Yamazaki, Gregory S. Walker, Melissa T. O’Gorman, Gabriella Bedarida, Helen Y. Zou, James G. Christensen, Leslie N. Nguyen, Zhongzhou Shen, Deepak Dalvie, Akintunde Bello & Bill J. Smith
Pages: 45-59
Published online: 18 Jul 2014
AbstractforMetabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects | Full Text | References | PDF (909.9 KB)
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Article
The comparative disposition and metabolism of dolutegravir, a potent HIV-1 integrase inhibitor, in mice, rats, and monkeys
Lee Moss, David Wagner, Eri Kanaoka, Katie Olson, Yun Lan Yueh & Gary D. Bowers
Pages: 60-70
Published online: 18 Jul 2014
AbstractforThe comparative disposition and metabolism of dolutegravir, a potent HIV-1 integrase inhibitor, in mice, rats, and monkeys | Full Text | References | PDF (767.7 KB)
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Article
Investigation on pharmacokinetics, tissue distribution and excretion of 1-triacontanol in rats by gas chromatography-tandem mass spectrometry (GC-MS/MS)
Chunfeng Wang, Ali Fan, Shuhua Deng, Wenchao Gao, Wei Zhang, Wei Yang, Xiaojie Zhu, Yang Lu & Xijing Chen
Pages: 71-78
Published online: 31 Jul 2014
AbstractforInvestigation on pharmacokinetics, tissue distribution and excretion of 1-triacontanol in rats by gas chromatography-tandem mass spectrometry (GC-MS/MS) | Full Text | References | PDF (681.7 KB)
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Article
A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine
Mohammad Reza Eskandari, Faezeh Moghaddam, Jafar Shahraki & Jalal Pourahmad
Pages: 79-87
Published online: 18 Jul 2014
AbstractforA comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine | Full Text | References | PDF (635.3 KB)
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Article
Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist
Xiaonan Li, Xiaolin Sun, Jiayin Chen, Yang Lu, Yongjie Zhang, Chunfeng Wang, Junxiu Li, Qing Zhang, Di Zhao & Xijing Chen
Pages: 88-94
Published online: 13 Aug 2014
AbstractforInvestigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist | Full Text | References | PDF (337.4 KB)
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