Xenobiotica, Volume 45, Issue 6 (2015)

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Xenobiotica, Volume 45, Issue 6 (2015)

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Research Article

Article
In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism
Christian Atsriku, Matthew Hoffmann, Mehran Moghaddam, Gondi Kumar & Sekhar Surapaneni
Pages: 465-480
Published online: 05 Dec 2014
AbstractforIn vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism | Full Text | References | PDF (2.4 MB)
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Article
Effects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro
Yue Yu, Yan Liu, Qian Li, Jiahui Sun, Haiou Lin & Gaofeng Liu
Pages: 481-487
Published online: 12 Dec 2014
AbstractforEffects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro | Full Text | References | PDF (481.8 KB)
  • 212 Views
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Article
In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats
Kazuo Oda, Naoyuki Nakada & Yasuhisa Nagasaka
Pages: 488-494
Published online: 24 Dec 2014
AbstractforIn vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats | Full Text | References | PDF (531.2 KB)
  • 371 Views
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Article
Characterization of bovine phenol sulfotransferases: evidence of a major role for SULT1B1 in the liver
Kanika V. Choughule, Charles W. Locuson & Michael W. H. Coughtrie
Pages: 495-502
Published online: 24 Dec 2014
AbstractforCharacterization of bovine phenol sulfotransferases: evidence of a major role for SULT1B1 in the liver | Full Text | References | PDF (590.2 KB)
  • 182 Views
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Article
Identification and functional characterization of novel feline cytochrome P450 2A
Gaku Okamatsu, Tetsuya Komatsu, Akira Kubota, Takenori Onaga, Tsuyoshi Uchide, Daiji Endo, Rikio Kirisawa, Guojun Yin, Hiroki Inoue, Takio Kitazawa, Yasuhiro Uno & Hiroki Teraoka
Pages: 503-510
Published online: 30 Dec 2014
AbstractforIdentification and functional characterization of novel feline cytochrome P450 2A | Full Text | References | PDF (683 KB)
  • 183 Views
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Article
Differences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10
Darja Gramec Skledar, Johanna Troberg, Jason Lavdas, Lucija Peterlin Mašič & Moshe Finel
Pages: 511-519
Published online: 30 Dec 2014
AbstractforDifferences in the glucuronidation of bisphenols F and S between two homologous human UGT enzymes, 1A9 and 1A10 | Full Text | References | PDF (598.2 KB)
  • 529 Views
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Article
Biotransformation and mass balance of the SGLT2 inhibitor empagliflozin in healthy volunteers
Lin-Zhi Chen, Arvid Jungnik, Yanping Mao, Elsy Philip, Dale Sharp, Anna Unseld, Leo Seman, Hans-Jürgen Woerle & Sreeraj Macha
Pages: 520-529
Published online: 30 Dec 2014
AbstractforBiotransformation and mass balance of the SGLT2 inhibitor empagliflozin in healthy volunteers | Full Text | References | PDF (1.7 MB)
  • 671 Views
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Article
Pharmacokinetics and tissue distribution study of novel potent antiplatelet agent S007-867 in mice using HPLC-MS/MS
Hardik Chandasana, Yashpal S. Chhonker, Yarra Durga Prasad, Tulsankar Sachin Laxman, K. S. Anil Kumar, Dinesh K. Dikshit & Rabi S. Bhatta
Pages: 530-537
Published online: 02 Apr 2015
AbstractforPharmacokinetics and tissue distribution study of novel potent antiplatelet agent S007-867 in mice using HPLC-MS/MS | Full Text | References | PDF (560.8 KB)
  • 195 Views
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Article
The mechanism of rapamycin in the intervention of paraquat-induced acute lung injury in rats
Da Chen, Guangyu Jiao, Tao Ma, Xiaowei Liu, Chen Yang & Zhi Liu
Pages: 538-546
Published online: 19 Dec 2014
AbstractforThe mechanism of rapamycin in the intervention of paraquat-induced acute lung injury in rats | Full Text | References | PDF (1 MB) | Supplemental
  • 176 Views
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Article
Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats
Liyue Huang, Xingwen Li, Jonathan Roberts, Brett Janosky & Min-Hwa Jasmine Lin
Pages: 547-555
Published online: 24 Dec 2014
AbstractforDifferential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats | Full Text | References | PDF (388 KB)
  • 538 Views
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Article
Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats
Keigo Kosaka, Tomoko Watanabe, Takeshi Susukida, Shigeki Aoki, Shuichi Sekine, Toshiyuki Kume & Kousei Ito
Pages: 556-562
Published online: 24 Dec 2014
AbstractforKey determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats | Full Text | References | PDF (570.3 KB)
  • 280 Views
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