Xenobiotica, Volume 47, Issue 9 (2017)

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Xenobiotica, Volume 47, Issue 9 (2017)

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General Xenobiochemistry

Article
Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set
Tetsuo Yamagata, Ugo Zanelli, Dieter Gallemann, Dominique Perrin, Hugues Dolgos & Carl Petersson
Pages: 741-751
Published online: 25 Aug 2016
AbstractforComparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set | Full Text | References | PDF (558.7 KB)
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Article
Use of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice
Xue-Feng Lu, Jian Zhan, Yang Zhou, Kai-Shun Bi & Xiao-Hui Chen
Pages: 752-762
Published online: 15 Sep 2016
AbstractforUse of a semi-physiological pharmacokinetic model to investigate the influence of itraconazole on tacrolimus absorption, distribution and metabolism in mice | Full Text | References | PDF (766.1 KB) | Supplemental
  • 221 Views
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Article
Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans
William Palmer-Brown, Brian Dunne, Yannick Ortin, Mark A. Fox, Graham Sandford & Cormac D. Murphy
Pages: 763-770
Published online: 15 Sep 2016
AbstractforBiotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans | Full Text | References | PDF (493.1 KB) | Supplemental
  • 210 Views
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Article
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution
Angela Hayes, N. Yi Mok, Manjuan Liu, Ching Thai, Alan T. Henley, Butrus Atrash, Rachel M. Lanigan, Jimmy Sejberg, Yann-Vaï Le Bihan, Vassilios Bavetsias, Julian Blagg & Florence I. Raynaud
Pages: 771-777
Published online: 26 Oct 2016
AbstractforPyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution | Full Text | References | PDF (999.7 KB) | Supplemental
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Open Access
Article
Screening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro
D. Chen, X.-X. Lin, Q. Zhao, J. Xiao, S.-F. Peng, M.-F. Xiao, D.-S. Ouyang, Z.-R. Tan, Y.-C. Wang, J.-B. Peng, W. Zhang & Y. Chen
Pages: 778-784
Published online: 15 Nov 2016
AbstractforScreening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro | Full Text | References | PDF (577.5 KB)
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Article
In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug–drug interaction risk prediction
Hongbo Xie, Jie Wu, Dan Liu, Mingyi Liu, Hong Zhang, Shibo Huang, Yuqing Xiong & Chunhua Xia
Pages: 785-792
Published online: 22 Sep 2016
AbstractforIn vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug–drug interaction risk prediction | Full Text | References | PDF (1.1 MB)
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Animal Pharmacokinetics and Metabolism

Article
Long circulation nanostructured lipid carriers for gambogenic acid: formulation design, characterization, and pharmacokinetic
Tongyuan Lin, Xia Huang, Yanyan Wang, Tingting Zhu, Qing Luo, Xiaoxiao Wang, Kai Zhou, Hao Cheng, Daiyin Peng & Weidong Chen
Pages: 793-799
Published online: 05 Dec 2016
AbstractforLong circulation nanostructured lipid carriers for gambogenic acid: formulation design, characterization, and pharmacokinetic | Full Text | References | PDF (852.8 KB)
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Open Access
Article
Evaluation of the tissue distribution, excretion, and cytochrome P450 induction studies of a potential antitumor agent, TM-2, in animals using LC-MS/MS
Lei Men, Yunli Zhao, Hongxin Lin, Xing Tang & Zhiguo Yu
Pages: 800-806
Published online: 30 Sep 2016
AbstractforEvaluation of the tissue distribution, excretion, and cytochrome P450 induction studies of a potential antitumor agent, TM-2, in animals using LC-MS/MS | Full Text | References | PDF (369.1 KB)
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Molecular Toxicology

Article
Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling
Josiah E. Hardesty, Banrida Wahlang, K. Cameron Falkner, Heather B. Clair, Barbara J. Clark, Brian P. Ceresa, Russell A. Prough & Matthew C. Cave
Pages: 807-820
Published online: 21 Jun 2017
AbstractforPolychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling | Full Text | References | PDF (1.2 MB) | Supplemental
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Xenobiotic Transporters

Article
Effect of proinflammatory cytokine IL-6 on efflux transport of rebamipide in Caco-2 cells
Masateru Miyake & Daisuke Nakai
Pages: 821-824
Published online: 07 Sep 2016
AbstractforEffect of proinflammatory cytokine IL-6 on efflux transport of rebamipide in Caco-2 cells | Full Text | References | PDF (245.6 KB)
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Article
Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions
Ryota Kikuchi, Vincent C. Peterkin, William J. Chiou, Sonia M. de Morais & Daniel A. J. Bow
Pages: 825-832
Published online: 03 Oct 2016
AbstractforValidation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions | Full Text | References | PDF (486 KB) | Supplemental
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Topics in Xenobiochemistry

Review
Who is the real killer? Chlorfenapyr or detergent micelle-chlorfenapyr complex?
Srinivasan Periasamy, Jou-Fang Deng & Ming-Yie Liu
Pages: 833-835
Published online: 03 Oct 2016
AbstractforWho is the real killer? Chlorfenapyr or detergent micelle-chlorfenapyr complex? | Full Text | References | PDF (230.2 KB)
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