Xenobiotica, Volume 50, Issue 3 (2020)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 50, Issue 3 (2020)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Volume 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition
S. Casey Laizure, Zhe-Yi Hu, Philip M. Potter & Robert B. Parker
Pages: 245-251
Published online: 15 May 2019
AbstractforInhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition | Full Text | References | PDF (709.5 KB) | EPUB
  • 473 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Metabolomics reveals the effect of valproic acid on MCF-7 and MDA-MB-231 cells
Xingzhi Zhou, Zhen Li, Xuanyu Wang, Ge Jiang, Changliang Shan & Shuangping Liu
Pages: 252-260
Published online: 04 Jun 2019
AbstractforMetabolomics reveals the effect of valproic acid on MCF-7 and MDA-MB-231 cells | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 303 Views
  • 8 CrossRef citations
  • 0Altmetric
Article
Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases
Kenta Mizoi, Masato Takahashi, Sachiko Sakai, Takuo Ogihara, Masami Haba & Masakiyo Hosokawa
Pages: 261-269
Published online: 19 Jun 2019
AbstractforStructure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 446 Views
  • 10 CrossRef citations
  • 0Altmetric
Article
Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery
Carl Petersson, Orestis Papasouliotis, Marc Lecomte, Lassina Badolo & Hugues Dolgos
Pages: 270-279
Published online: 19 Jun 2019
AbstractforPrediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1198 Views
  • 8 CrossRef citations
  • 0Altmetric
Article
Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazole on the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentan in rats
Mengchun Chen, Xufei Zhang, Yijie Chen, Wei Sun, Zhe Wang, Chengke Huang, Guoxin Hu & Ruijie Chen
Pages: 280-287
Published online: 03 Jul 2019
AbstractforComparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazole on the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentan in rats | Full Text | References | PDF (1.3 MB) | EPUB
  • 199 Views
  • 4 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetic modeling analysis of cilostazol and its active metabolites (OPC-13015 and OPC-13213) after multiple oral doses of cilostazol in healthy Korean volunteers
Ailing Cui, Yo Han Kim, Jong-Lyul Ghim, Jin Ah Jung, Sang-Heon Cho, Sangmin Choe, Hee Youn Choi, Kyun-Seop Bae & Hyeong-Seok Lim
Pages: 288-296
Published online: 03 Jul 2019
AbstractforPharmacokinetic modeling analysis of cilostazol and its active metabolites (OPC-13015 and OPC-13213) after multiple oral doses of cilostazol in healthy Korean volunteers | Full Text | References | PDF (2 MB) | EPUB
  • 246 Views
  • 3 CrossRef citations
  • 0Altmetric
Review
Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokinetics
Yingmin Nie, Jingjie Yang, Shuai Liu, Ruiqi Sun, Huihui Chen, Nan Long, Rui Jiang & Chunshan Gui
Pages: 297-317
Published online: 24 Jun 2019
AbstractforGenetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokinetics | Full Text | References | PDF (2.6 MB) | EPUB
  • 547 Views
  • 16 CrossRef citations
  • 0Altmetric
Article
An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity
Roger J. Price, Rachel Burch, Lynsey R. Chatham, Larry G. Higgins, Richard A. Currie & Brian G. Lake
Pages: 318-322
Published online: 19 Jun 2019
AbstractforAn assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity | Full Text | References | PDF (518.8 KB) | EPUB
  • 253 Views
  • 4 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
A sensitive LC-MS/MS method to determine ginkgolide B in human plasma and urine: application in a pharmacokinetics and excretion study of healthy Chinese subjects
Chenlin Shen, Xiaoqin Jin, Maomao Wu, Xiaohui Huang, Jun Li, Hong Huang, Feilong Li, Jiatao Liu, Genxiang Rong & Shuai Song
Pages: 323-331
Published online: 15 May 2019
AbstractforA sensitive LC-MS/MS method to determine ginkgolide B in human plasma and urine: application in a pharmacokinetics and excretion study of healthy Chinese subjects | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 122 Views
  • 4 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Dihydromyricetin affect the pharmacokinetics of triptolide in rats
Yang Deng, Lin Guo, Hualin Cai, Lei Chen, Shenglan Tan, Bikui Zhang, Pingfei Fang, Daxiong Xiang, Huande Li, Guixia He & Miao Yan
Pages: 332-338
Published online: 27 May 2019
AbstractforDihydromyricetin affect the pharmacokinetics of triptolide in rats | Full Text | References | PDF (1.1 MB) | EPUB
  • 179 Views
  • 7 CrossRef citations
  • 0Altmetric
Article
Uptake and pharmacokinetics of cefuroxime in rabbits after intravitreal, intracameral, and topical dosing: relevance to human ocular injection of cefuroxime
Ravi Kumar Jairam, Sadanand R. Mallurwar, Bhavesh B. Gabani, Ashok Zakkula, Vinay Kiran, Sreekanth Dittakavi, Suresh P. Sulochana, Zainuddin Mohd, Nuggehally R. Srinivas & Ramesh Mullangi
Pages: 339-345
Published online: 19 Jun 2019
AbstractforUptake and pharmacokinetics of cefuroxime in rabbits after intravitreal, intracameral, and topical dosing: relevance to human ocular injection of cefuroxime | Full Text | References | PDF (723.8 KB) | EPUB | Supplemental
  • 269 Views
  • 5 CrossRef citations
  • 0Altmetric

Xenobiotic transporters

Article
Influence of ABCB1 (1236C > T, 2677G > T and 3435C > T) polymorphisms on the transport ability of P-gp-mediated sunitinib in Caco-2 cell line
Da-Qing Tan
Pages: 346-353
Published online: 15 May 2019
AbstractforInfluence of ABCB1 (1236C > T, 2677G > T and 3435C > T) polymorphisms on the transport ability of P-gp-mediated sunitinib in Caco-2 cell line | Full Text | References | PDF (1.6 MB) | EPUB
  • 141 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro
Ziyan Fei, Mengyun Hu, Larry Baum, Patrick Kwan, Tao Hong & Chunbo Zhang
Pages: 354-362
Published online: 09 Jun 2019
AbstractforThe potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro | Full Text | References | PDF (2 MB) | EPUB
  • 256 Views
  • 7 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
SNP’s in xenobiotic metabolism and male infertility
Neslihan Hekim, Mohamed Ali Gure, Asli Metin Mahmutoglu, Sezgin Gunes, Ramazan Asci & Ralf Henkel
Pages: 363-370
Published online: 29 May 2019
AbstractforSNP’s in xenobiotic metabolism and male infertility | Full Text | References | PDF (1.6 MB) | EPUB
  • 442 Views
  • 3 CrossRef citations
  • 0Altmetric

Explore articles