Cancer Biology & Therapy, Volume 5, Issue 1 (2006)

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Cancer Biology & Therapy, Volume 5, Issue 1 (2006)

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Editor's Corner

Editorial
Cover Image
Page: i
Published online: 03 Jan 2006
AbstractforCover Image | PDF (1.2 MB)
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News

News
El-Deiry Recognized in 2005 by ISI as Highly Cited Over 20 Year Period in Molecular Biology and Genetics
Page: 9
Published online: 05 Dec 2005
AbstractforEl-Deiry Recognized in 2005 by ISI as Highly Cited Over 20 Year Period in Molecular Biology and Genetics | PDF (249.8 KB)
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News
Involvement of Stem Cell Genes in Breast and Germ Cell Tumors
Page: 9
Published online: 05 Dec 2005
AbstractforInvolvement of Stem Cell Genes in Breast and Germ Cell Tumors | PDF (249.8 KB)
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News
The Tyrosine Kinase Ack1 Promotes Prostate Tumor Growth
Page: 9
Published online: 05 Dec 2005
AbstractforThe Tyrosine Kinase Ack1 Promotes Prostate Tumor Growth | PDF (249.8 KB)
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News
Visualizing an Immune Response to Cancer
Page: 9
Published online: 05 Dec 2005
AbstractforVisualizing an Immune Response to Cancer | PDF (249.8 KB)
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News
Mammaglobin as a Biomarker to Detect Breast Cancer Recurrence
Page: 9
Published online: 05 Dec 2005
AbstractforMammaglobin as a Biomarker to Detect Breast Cancer Recurrence | PDF (249.8 KB)
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News
Survival Benefit in Early Stage Breast Cancer of Herceptin Plus a Chemotherapy Regimen Lacking Adriamycin
Page: 9
Published online: 03 Jan 2006
AbstractforSurvival Benefit in Early Stage Breast Cancer of Herceptin Plus a Chemotherapy Regimen Lacking Adriamycin | PDF (249.8 KB)
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News
Role of Cyclin D1/2 and CDK4/6 in Myeloma Relapse
Page: 9
Published online: 03 Jan 2006
AbstractforRole of Cyclin D1/2 and CDK4/6 in Myeloma Relapse | PDF (249.8 KB)
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News
Activity of AMN107 in Gleevec-resistant Leukemia
Page: 9
Published online: 03 Jan 2006
AbstractforActivity of AMN107 in Gleevec-resistant Leukemia | PDF (249.8 KB)
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News
Targeting MDC1-Mediated Homologous Recombination and Repair as a Therapeutic Possibility
Page: 9
Published online: 03 Jan 2006
AbstractforTargeting MDC1-Mediated Homologous Recombination and Repair as a Therapeutic Possibility | PDF (249.8 KB)
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Review

Review Article
Cancer-selective therapy of the future: Apoptin and its mechanism of action
Subbareddy Maddika, Francisco J. Mendoza, Kristin Hauff, Christina R. Zamzow, Ted Paranjothy & Marek Los
Pages: 10-19
Published online: 16 Jan 2006
AbstractforCancer-selective therapy of the future: Apoptin and its mechanism of action | PDF (284 KB)
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Journal Club

Klotho, the long sought-after elixir and a novel tumor suppressor?
Y. Alan Wang
Pages: 20-21
Published online: 16 Jan 2006
AbstractforKlotho, the long sought-after elixir and a novel tumor suppressor? | PDF (178.8 KB)
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Clinical Trials

Article
Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors
William L. Dahut, Nehal J. Lakhani, James L. Gulley, Philip M. Arlen, Elise C. Kohn, Herbert Kotz, Debbie McNally, Allyson Parr, Allyson Parr, Diana Nguyen, Sherry X. Yang, Seth M. Steinberg, Jürgen Venitz, Alex Sparreboom & William Figg, II
Pages: 22-27
Published online: 16 Jan 2006
AbstractforPhase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors | PDF (468.2 KB)
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Research Paper

Article
Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata
Ming-Lin Liang, Hongbo Wang, Yuan Zhang, Shi Lu & Zehua Wang
Pages: 28-33
Published online: 16 Jan 2006
AbstractforExpression and functional analysis of platelet-derived growth factor in uterine leiomyomata | PDF (513.6 KB)
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Article
Use of the 13C-sucrose breath test to assess chemotherapy-induced small intestinal mucositis in the rat
Julie M. Clarke, Nicole C. Pelton, Balazs H. Bajka, Gordon S. Howarth, Leanna C. Read & Ross N. Butler
Pages: 34-38
Published online: 16 Jan 2006
AbstractforUse of the 13C-sucrose breath test to assess chemotherapy-induced small intestinal mucositis in the rat | PDF (285.5 KB)
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Article
Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo
Zhi Shi, Yong-ju Liang, Zhe-sheng Chen, Xiu-wen Wang, Xiao-hong Wang, Yan Ding, Li-meng Chen, Xiao-ping Yang & Li-wu Fu
Pages: 39-47
Published online: 16 Jan 2006
AbstractforReversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo | PDF (973.4 KB)
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Article
Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma
Prasad S. Adusumilli, Mei-Ki Chan, Yun Shin Chun, Michael Hezel, Ting-Chao Chou, Valerie W. Rusch & Yuman Fong
Pages: 48-53
Published online: 16 Jan 2006
AbstractforCisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma | PDF (333.6 KB)
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Article
Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential display
Mercedes Martín-Rufián, Juan A. Segura, Carolina Lobo, José Matés, Javier Márquez & Francisco J. Alonso
Pages: 54-58
Published online: 16 Jan 2006
AbstractforIdentification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential display | PDF (508.6 KB)
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Article
Corticosteriod-induced chemotherapy resistance in urological cancers
C Zhang, Jürgen Mattern, Axel Haferkamp, Jesco Pfitzenmaier, Markus Hohenfellner, Werner Rittgen, Lutz Edler, Klaus-Michael Debatin, E Groene & Ingrid Herr
Pages: 59-64
Published online: 16 Jan 2006
AbstractforCorticosteriod-induced chemotherapy resistance in urological cancers | PDF (453 KB)
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Article
Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins
Volodymyr P. Tryndyak, Olga Kovalchuk & Igor P. Pogribny
Pages: 65-70
Published online: 16 Jan 2006
AbstractforLoss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins | PDF (391.9 KB)
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Article
The role of relaxin in endometrial cancer
Aparna A. Kamat, Shu Feng, Irina U. Agoulnik, Farrah Kheradmand, Natalia V. Bogatcheva, Donna Coffey, Anil K. Sood & Alexander I. Agoulnik
Pages: 71-77
Published online: 16 Jan 2006
AbstractforThe role of relaxin in endometrial cancer | PDF (606.4 KB)
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Article
CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer
Moon S. Koh, Michael Ittmann, Dov Kadmon, Timothy C. Thompson & Fredrick S. Leach
Pages: 78-83
Published online: 16 Jan 2006
AbstractforCDC4 gene expression as potential biomarker for targeted therapy in prostate cancer | PDF (822.2 KB)
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Article
pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade
Francesca Sanseverino, Rosa Santopietro, Michela Torricelli, Giuseppina D'Andrilli, Giuseppe Russo, Gabriele Cevenini, Alessandro Bovicelli, Lorenzo Leoncini, Giovanni Scambia, Felice Petraglia, Pier Paolo Claudio & Antonio Giordano
Pages: 84-88
Published online: 16 Jan 2006
AbstractforpRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade | PDF (377.1 KB)
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Article
Paclitaxel encapsulated in cationic lipid complexes (MBT-0206) impairs functional tumor vascular properties as detected by dynamic contrast enhanced magnetic resonance imaging
M.E. Eichhorn, S Becker, S. Strieth, A Werner, B. Sauer, M. Teifel, H. Ruhstorfer, U. Michaelis, Jürgen Griebel, G. Brix, Karl-Walter Jauch & M. Dellian
Pages: 89-96
Published online: 16 Jan 2006
AbstractforPaclitaxel encapsulated in cationic lipid complexes (MBT-0206) impairs functional tumor vascular properties as detected by dynamic contrast enhanced magnetic resonance imaging | PDF (731.2 KB)
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Article
Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: Topoisomerase II-alpha coamplification
Amr Y. Esmat, Catherine Tomasetto & Marie-Christine Rio
Pages: 97-103
Published online: 16 Jan 2006
AbstractforCytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: Topoisomerase II-alpha coamplification | PDF (582.1 KB)
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Article
Differential gene expression profiling in aggressive bladder transitional cell carcinoma compared to the adjacent microscopically normal urothelium by microdissection-SMART cDNA PCR-SSH
H. T. Wang, F. L. Ma, X. B. Ma, R. F. Han, Y. B. Zhang & J. W. Chang
Pages: 104-110
Published online: 16 Jan 2006
AbstractforDifferential gene expression profiling in aggressive bladder transitional cell carcinoma compared to the adjacent microscopically normal urothelium by microdissection-SMART cDNA PCR-SSH | PDF (701.3 KB)
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Article
Hedgehog signaling in human hepatocellular carcinoma
Mohini A. Patil, Ji Zhang, Coral Ho, Siu-Tim Cheung, Sheung-Tat Fan & Xin Chen
Pages: 111-117
Published online: 16 Jan 2006
AbstractforHedgehog signaling in human hepatocellular carcinoma | PDF (645.3 KB)
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Commentary

Targeted radiation for melanoma: Alpha therapy prepares for a beta test
Joseph N. Contessa & Peter L. Robertson
Pages: 118-119
Published online: 16 Jan 2006
AbstractforTargeted radiation for melanoma: Alpha therapy prepares for a beta test | PDF (152.3 KB)
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Profiles and Legacies

Editorial
Such an obsession
David P. Lane
Pages: 120-123
Published online: 16 Jan 2006
AbstractforSuch an obsession | PDF (838.6 KB)
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