Cancer Biology & Therapy, Volume 6, Issue 5 (2007)

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Cancer Biology & Therapy, Volume 6, Issue 5 (2007)

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Editor's Corner

Editorial
Cover Image
Page: i
Published online: 30 May 2007
AbstractforCover Image | PDF (1.1 MB)
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News

News
Imaging to Predict Therapeutic Response of Metastatic Disease to Bone
Page: 638
Published online: 30 May 2007
AbstractforImaging to Predict Therapeutic Response of Metastatic Disease to Bone | PDF (986.6 KB)
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News
Proteasome Inhibitor NPI-0052 Appears More Effective than Bortezomib in Treatment of Leukemia in Animal Models
Pages: 638-639
Published online: 30 May 2007
AbstractforProteasome Inhibitor NPI-0052 Appears More Effective than Bortezomib in Treatment of Leukemia in Animal Models | PDF (986.6 KB)
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News
Proof-of-Principle That Targeting Telomerase Can Block Cancer Development Through Senescence Even if Cell Death is Blocked
Page: 638
Published online: 30 May 2007
AbstractforProof-of-Principle That Targeting Telomerase Can Block Cancer Development Through Senescence Even if Cell Death is Blocked | PDF (986.6 KB)
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News
Identifying Cancer Genetic Markers of Susceptibility Using High-Throughput SNP Arrays
Pages: 638-639
Published online: 30 May 2007
AbstractforIdentifying Cancer Genetic Markers of Susceptibility Using High-Throughput SNP Arrays | PDF (986.6 KB)
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News
MET Amplification and Resistance to EGFR-Targeted Small Molecule Therapies
Page: 638
Published online: 30 May 2007
AbstractforMET Amplification and Resistance to EGFR-Targeted Small Molecule Therapies | PDF (986.6 KB)
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News
Gene Signature in Simple Blood Test May Predict Dose of Radiation Exposure
Pages: 638-639
Published online: 30 May 2007
AbstractforGene Signature in Simple Blood Test May Predict Dose of Radiation Exposure | PDF (986.6 KB)
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News
EREG, COX2, MMP1 and MMP2 Orchestrate Breast Tumor Metastases
Page: 638
Published online: 30 May 2007
AbstractforEREG, COX2, MMP1 and MMP2 Orchestrate Breast Tumor Metastases | PDF (986.6 KB)
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News
Pier Paolo Pandolfi Moves to Direct a new Cancer Genetics Program at Beth-Israel Deaconess Medical Center and Harvard Medical School
Page: 638
Published online: 30 May 2007
AbstractforPier Paolo Pandolfi Moves to Direct a new Cancer Genetics Program at Beth-Israel Deaconess Medical Center and Harvard Medical School | PDF (986.6 KB)
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News
Steven Piantadosi to Direct Comprehensive Cancer Institute at Cedars-Sinai Medical Center
Pages: 638-639
Published online: 30 May 2007
AbstractforSteven Piantadosi to Direct Comprehensive Cancer Institute at Cedars-Sinai Medical Center | PDF (986.6 KB)
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News
Matthew Seiden Named President and CEO of Fox Chase Cancer Center
Pages: 638-639
Published online: 30 May 2007
AbstractforMatthew Seiden Named President and CEO of Fox Chase Cancer Center | PDF (986.6 KB)
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News
Comprehensive Cancer Center at Stanford
Pages: 638-639
Published online: 30 May 2007
AbstractforComprehensive Cancer Center at Stanford | PDF (986.6 KB)
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News
Nicholas Petrelli Elected President of the Society of Surgical Oncology
Pages: 638-639
Published online: 30 May 2007
AbstractforNicholas Petrelli Elected President of the Society of Surgical Oncology | PDF (986.6 KB)
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Review

Review Article
The pathology of tumor stromatogenesis
Alexandra Giatromanolaki, Efthimios Sivridis & Michael I. Koukourakis
Pages: 639-645
Published online: 30 May 2007
AbstractforThe pathology of tumor stromatogenesis | PDF (209.8 KB)
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Journal Club

Targeting ROS: Selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound
Xin-jiang Wu & Xianxin Hua
Pages: 646-647
Published online: 30 May 2007
AbstractforTargeting ROS: Selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound | PDF (143.8 KB)
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Clinical Trials

Article
A phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors
Xubin Lin, Huiqiang Huang, Su Li, Hongli Li, Yuhong Li, Ye Cao, Dongsheng Zhang, Yunfei Xia, Ying Guo, Wenlin Huang & Wenqi Jiang
Pages: 648-653
Published online: 30 May 2007
AbstractforA phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors | PDF (793.4 KB)
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Brief Communication

Brief Report
Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer
Eike Gallmeier, Tomas Hucl, Eric S. Calhoun, Steven C. Cunningham, Fred Bunz, Jonathan R. Brody & Scott E. Kern
Pages: 654-660
Published online: 30 May 2007
AbstractforGene-specific selection against experimental fanconi anemia gene inactivation in human cancer | PDF (583.2 KB)
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Brief Report
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors
Yuki Yuza, Karen A. Glatt, Jingrui Jiang, Heidi Greulich, Yuko Minami, Michele S. Woo, Takeshi Shimamura, Geoffrey I. Shapiro, Jeffrey C. Lee, Hongbin Ji, Whei Feng, Tzu-Hsiu Chen, Haruhiko Yanagisawa, Kwok-Kin Wong & Matthew Meyerson
Pages: 661-667
Published online: 30 May 2007
AbstractforAllele-dependent variation in the relative cellular potency of distinct EGFR inhibitors | PDF (428.2 KB)
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Research Paper

Article
Expression profiling reveals dysregulation of cellular cytoskeletal genes in HBx–induced hepatocarcinogenesis
Qiang Sun, Youliang Wang, Yingai Zhang, Fang Liu, Xuan Cheng, Nin Hou, Xiaohang Zhao & Xiao Yang
Pages: 668-674
Published online: 30 May 2007
AbstractforExpression profiling reveals dysregulation of cellular cytoskeletal genes in HBx–induced hepatocarcinogenesis | PDF (628.2 KB)
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Article
Zebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin
Kevin T. Duffy & Eric Wickstrom
Pages: 675-678
Published online: 30 May 2007
AbstractforZebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin | PDF (383 KB)
  • 463 Views
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Article
Comparative evaluation of survivin, midkine, and CXCR4 promoters for transcriptional targeting of glioma gene therapy
Ilya V. Ulasov, Angel A. Rivera, Adam M. Sonabend, Adam M. Sonabend, Ming Wang, Zeng B. Zhu, Maciej S. Lesniak & Lisa B. Rivera
Pages: 679-685
Published online: 30 May 2007
AbstractforComparative evaluation of survivin, midkine, and CXCR4 promoters for transcriptional targeting of glioma gene therapy | PDF (312.9 KB)
  • 408 Views
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Article
Defibrotide: An endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo
Gudrun E. Koehl, Edward K. Geissler, Massimo Iacobelli, Caroline Frei, Verena Burger, Silvia Haffner, Ernst Holler, Reinhard Andreesen, Hans J. Schlitt & Günther Eissner
Pages: 686-690
Published online: 30 May 2007
AbstractforDefibrotide: An endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo | PDF (385.5 KB)
  • 597 Views
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Article
Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, A gambogic acid derivative, in human leukemia HL-60 cells
Zhijian Tao, Yunlong Zhou, Jinjian Lu, Wenhu Duan, Xinxia He, Liping Lin, Jian Ding & Yuxin Qin
Pages: 691-696
Published online: 30 May 2007
AbstractforCaspase-8 preferentially senses the apoptosis-inducing action of NG-18, A gambogic acid derivative, in human leukemia HL-60 cells | PDF (476.7 KB)
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Article
Phi29 pRNA vector for efficient escort of hammerhead ribozyme targeting survivin in multiple cancer cells
Hongyun Li, Songchuan Guo, Richard Roll, Jie Li, Zhijuan Diao, Ningsheng Shao, Mark R. Riley, Alexander M. Cole, J. Paul Robinson, Nicholas Snead, Guanxin Shen & Peixuan Guo
Pages: 697-704
Published online: 30 May 2007
AbstractforPhi29 pRNA vector for efficient escort of hammerhead ribozyme targeting survivin in multiple cancer cells | PDF (812.4 KB)
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Article
Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-Hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells
Humam Kadara, Ludovic Lacroix, Dafna Lotan & Reuben Lotan
Pages: 705-711
Published online: 30 May 2007
AbstractforInduction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-Hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells | PDF (630.1 KB)
  • 424 Views
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Article
Exploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer
Zhi Jiang Zang, Khe Guan Sim, Jit Kong Cheong, Christopher Maolin Yang, Chui Sun Yap & Stephen I-Hong Hsu
Pages: 712-718
Published online: 30 May 2007
AbstractforExploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer | PDF (605.5 KB)
  • 394 Views
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Article
A new putative target for antisense gene therapy of glioma: Glycogen synthase
Maryvonne Ardourel, Marion Blin, Jean-Luc Moret, Thierry Dufour, Huynh-Thien Duc, Tobias Hévor, Jerzy Trojan & Jean-François Cloix
Pages: 719-723
Published online: 30 May 2007
AbstractforA new putative target for antisense gene therapy of glioma: Glycogen synthase | PDF (243.7 KB)
  • 268 Views
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Article
Immune analysis on mtHSV mediated tumor therapy in HSV-1 seropositive mice
Huabin Zhu, Yue Su, Shumin Zhou, Wei Xiao, Weifang Ling, Baoli Hu, Yingle Liu & Yipeng Qi
Pages: 724-731
Published online: 30 May 2007
AbstractforImmune analysis on mtHSV mediated tumor therapy in HSV-1 seropositive mice | PDF (655.4 KB)
  • 227 Views
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Article
Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival
Oskar Rokhlin, Agshin F. Taghiyev, K. Ulrich Bayer, David Bumcrot, Victor E Kotelianski, Rebecca A. Glover & Michael B. Cohen
Pages: 732-742
Published online: 30 May 2007
AbstractforCalcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival | PDF (896 KB)
  • 1065 Views
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Article
Axon guidance cue Netrin-1 has dual function in angiogenesis
Yun Yang, Li Zou, Yong Wan, Ke-Shu Xu, Jin-Xiang Zhang & Jing-Hui Zhang
Pages: 743-748
Published online: 30 May 2007
AbstractforAxon guidance cue Netrin-1 has dual function in angiogenesis | PDF (410.6 KB)
  • 538 Views
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Article
Assessment of apoptosis-inducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells
Cecilia S. Jung, Zhongmei Zhou, Fadlo R. Khuri & Shi-Yong Sun
Pages: 749-754
Published online: 30 May 2007
AbstractforAssessment of apoptosis-inducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells | PDF (533.5 KB)
  • 245 Views
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Article
AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
Sandra Koseoglu, Zhuomei Lu, Chandra Kumar, Paul Kirschmeier & Jun Zou
Pages: 755-762
Published online: 30 May 2007
AbstractforAKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines | PDF (547.7 KB)
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Article
Cancer stem-like cells in human prostate carcinoma cells DU145: The seeds of the cell line?
Chen Wei, Wang Guomin, Liu Yujun & Qian Ruizhe
Pages: 763-768
Published online: 30 May 2007
AbstractforCancer stem-like cells in human prostate carcinoma cells DU145: The seeds of the cell line? | PDF (1.4 MB)
  • 2354 Views
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Article
Hypoxia induced overexpression of PrPC in gastric cancer cell lines
Jie Liang, Feihu Bai, Guanhong Luo, Jingbo Wang, Jingmei Liu, Fulin Ge, Yanglin Pan, Liping Yao, Rui Du, Xiaohua Li, Rui Fan, Hongbo Zhang, Xuegang Guo, Kaichun Wu & Daiming Fan
Pages: 769-774
Published online: 30 May 2007
AbstractforHypoxia induced overexpression of PrPC in gastric cancer cell lines | PDF (343 KB)
  • 410 Views
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Article
A novel polypeptide from shark cartilage with potent anti-angiogenic activity
Lanhong Zheng, Peixue Ling, Zheng Wang, Rongli Niu, Chaoxin Hu, Tianmin Zhang & Xiukun Lin
Pages: 775-780
Published online: 30 May 2007
AbstractforA novel polypeptide from shark cartilage with potent anti-angiogenic activity | PDF (322.9 KB)
  • 733 Views
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Article
Immune response to firefly luciferase as a naked DNA
Yong Hyun Jeon, Yun Choi, Joo Hyun Kang, Chul Woo Kim, Jae Min Jeong, Dong Soo Lee & June-Key Chung
Pages: 781-786
Published online: 30 May 2007
AbstractforImmune response to firefly luciferase as a naked DNA | PDF (410.3 KB)
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Article
BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles
Weihong Li, Yong Shao, Lihong Hu, Xiongwen Zhang, Yi Chen, Linjiang Tong, Chuan Li, Xu Shen & Jian Ding
Pages: 787-794
Published online: 30 May 2007
AbstractforBM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles | PDF (688.8 KB)
  • 594 Views
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Article
Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy
Dineo Khabele, Deok-Soo Son, Angelika K. Parl, Gary L. Goldberg, Leonard H. Augenlicht, John M. Mariadason & Valerie Montgomery Rice
Pages: 795-801
Published online: 30 May 2007
AbstractforDrug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: Implications for therapy | PDF (624.3 KB)
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Commentary

Aiding and ABT’ing treatment for glioblastoma
Elaine Y. Chung, Michael Dews, Amit Maity & Andrei Thomas-Tikhonenko
Pages: 802-804
Published online: 30 May 2007
AbstractforAiding and ABT’ing treatment for glioblastoma | PDF (245.6 KB)
  • 142 Views
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Profiles and Legacies

Editorial
Pursuing the androgen pathway on the quest to control prostate cancer
Donald J. Tindall
Pages: 805-810
Published online: 30 May 2007
First Page PreviewforPursuing the androgen pathway on the quest to control prostate cancer | PDF (241.5 KB)
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Editorial
The accidental cancer geneticist: Hilário de Gouvêa and hereditary retinoblastoma
Alvaro N.A. Monteiro & Ricardo Waizbort
Pages: 811-813
Published online: 30 May 2007
AbstractforThe accidental cancer geneticist: Hilário de Gouvêa and hereditary retinoblastoma | PDF (182 KB)
  • 663 Views
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