Cancer Biology & Therapy, Volume 7, Issue 10 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 10 (2008)

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Editor's Corner

Editorial
Cover Caption
Page: i
Published online: 01 Oct 2008
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News

News
Penn medicine advances real-time medicine: The Ruth and Raymond Perelman Center for Advanced Medicine helps heal patients through innovative building design
Pages: 1515-1514
Published online: 01 Oct 2008
AbstractforPenn medicine advances real-time medicine: The Ruth and Raymond Perelman Center for Advanced Medicine helps heal patients through innovative building design | PDF (720.7 KB)
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News
Victor A. McKusick, M.D.: Father of Medical Genetics 1921-2008
Pages: 1515-1514
Published online: 01 Oct 2008
AbstractforVictor A. McKusick, M.D.: Father of Medical Genetics 1921-2008 | PDF (720.7 KB)
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Special Article

Article
Potential for all-trans retinoic acid [tretinoin] to enhance interferon-alpha treatment response in chronic myelogenous leukemia, melanoma, myeloma, and renal cell carcinoma
R.E. Kast
Pages: 1515-1519
Published online: 01 Oct 2008
AbstractforPotential for all-trans retinoic acid [tretinoin] to enhance interferon-alpha treatment response in chronic myelogenous leukemia, melanoma, myeloma, and renal cell carcinoma | PDF (804.9 KB)
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Article
Prevention of cancer by inhibiting aging
Mikhail V Blagosklonny
Pages: 1520-1524
Published online: 01 Oct 2008
AbstractforPrevention of cancer by inhibiting aging | PDF (201.4 KB)
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Review

Review Article
In vivo imaging of apoptosis
Francis G. Blankenberg
Pages: 1525-1532
Published online: 01 Oct 2008
AbstractforIn vivo imaging of apoptosis | PDF (1.5 MB)
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Review Article
Advances in pediatric hematopoietic stem cell transplantation
Raymond Carlton Barfield, Kimberly Anne Kasow & Gregory Alan Hale
Pages: 1533-1539
Published online: 01 Oct 2008
AbstractforAdvances in pediatric hematopoietic stem cell transplantation | PDF (591 KB)
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Review Article
Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase
Zeina Kais & Jeffrey D. Parvin
Pages: 1540-1543
Published online: 01 Oct 2008
AbstractforRegulation of centrosomes by the BRCA1-dependent ubiquitin ligase | PDF (598.5 KB)
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Bedside to Bench Report

Article
Successful treatment of relapsed lymphomatoid granulomatosis with bexarotene
Sigrid E. Berg, Lisa H. Downs, Drew A. Torigian, Elise A. Chong, Donald E. Tsai, Mariusz A. Wasik & Stephen J. Schuster
Pages: 1544-1546
Published online: 01 Oct 2008
AbstractforSuccessful treatment of relapsed lymphomatoid granulomatosis with bexarotene | PDF (712.4 KB)
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Research Paper

Article
Preparation and testing of bevacizumab radioimmunoconjugates with Bismuth-213 and Bismuth-205 / Bismuth-206
Syed M. Abbas Rizvi, Emma YanJun Song, Chand Raja, Julia Beretov, Alfred Morgenstern, Christos Apostolidis, Pamela J Russell, John H Kearsley, K Abbas & Barry J Allen
Pages: 1547-1554
Published online: 01 Oct 2008
AbstractforPreparation and testing of bevacizumab radioimmunoconjugates with Bismuth-213 and Bismuth-205 / Bismuth-206 | PDF (1.3 MB)
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Article
siRNA-mediated inhibition of hTERT enhances chemosensitivity of hepatocellular carcinoma
Xianling Guo, Weifen Wang, Feiguo Zhou, Zhenghua Lu, Ruifang Fang, Fengqi Jia, Xinxin Bu, Rong Li, Baihe Zhang, Mengchao Wu & Lixin Wei
Pages: 1555-1560
Published online: 01 Oct 2008
AbstractforsiRNA-mediated inhibition of hTERT enhances chemosensitivity of hepatocellular carcinoma | PDF (1.2 MB)
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Article
Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy
Manuel Rieber & Mary Strasberg Rieber
Pages: 1561-1566
Published online: 01 Oct 2008
AbstractforSensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy | PDF (1.3 MB)
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Commentary

Update on radiosensitization by halogenated thymidine analogs-molecular mechanisms of drug processing and cell death signaling: Implications for future clinical trials
Timothy J. Kinsella
Pages: 1567-1569
Published online: 01 Oct 2008
AbstractforUpdate on radiosensitization by halogenated thymidine analogs-molecular mechanisms of drug processing and cell death signaling: Implications for future clinical trials | PDF (668.8 KB)
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Research Paper

Article
HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling
Cassandra A. Godman, Rashmi Joshi, Brendan R. Tierney, Emily Greenspan, Theodore P. Rasmussen, Hsin-wei Wang, Dong-Guk Shin, Daniel W. Rosenberg & Charles Giardina
Pages: 1570-1580
Published online: 01 Oct 2008
AbstractforHDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling | PDF (2.9 MB)
  • 611 Views
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Commentary

Dissecting HDAC3-mediated tumor progression
John M. Mariadason
Pages: 1581-1583
Published online: 01 Oct 2008
AbstractforDissecting HDAC3-mediated tumor progression | PDF (616.3 KB)
  • 283 Views
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Research Paper

Article
Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells
SL Showalter, Y-H Huang, A Witkiewicz, CL Costantino, CJ Yeo, JJ Green, R Langer, DG Anderson, JA Sawicki & JR Brody
Pages: 1584-1590
Published online: 01 Oct 2008
AbstractforNanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells | PDF (1.1 MB)
  • 456 Views
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Commentary

A step towards a new targeted nanotherapy for pancreatic cancer
Judith C. Keen
Pages: 1591-1592
Published online: 01 Oct 2008
AbstractforA step towards a new targeted nanotherapy for pancreatic cancer | PDF (501.2 KB)
  • 222 Views
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Research Paper

Article
Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma
Baojin Fu, Mingde Luo, Sindhu Lakkur, Robert Lucito & Christine A. Iacobuzio-Donahue
Pages: 1593-1601
Published online: 01 Oct 2008
AbstractforFrequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma | PDF (1.2 MB)
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Article
Suppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells
Mo X-Lan, Su Z-Lan, Zhang F-Cheng, He Dan & Lu H-Qiong
Pages: 1602-1606
Published online: 01 Oct 2008
AbstractforSuppression of EBNA1 expression inhibits growth of EBV-positive NK/T cell lymphoma cells | PDF (795.6 KB)
  • 385 Views
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Article
Gene microarray analysis of human renal cell carcinoma: The effects of HDAC inhibition and retinoid treatment
Trisha S. Tavares, David Nanus, Ximing J. Yang & Lorraine J. Gudas
Pages: 1607-1618
Published online: 01 Oct 2008
AbstractforGene microarray analysis of human renal cell carcinoma: The effects of HDAC inhibition and retinoid treatment | PDF (1.7 MB)
  • 473 Views
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Article
Inhibition of Mxi1 suppresses HIF-2α-dependent renal cancer tumorigenesis
Chun Chui Tsao, Bin T. Teh, Eric Jonasch, Nicole Shreiber-Agus, Eleni Efstathiou, Anh Hoang, P. Bogdan Czerniak, Christopher Logothetis & Paul G. Corn
Pages: 1619-1627
Published online: 01 Oct 2008
AbstractforInhibition of Mxi1 suppresses HIF-2α-dependent renal cancer tumorigenesis | PDF (2.7 MB)
  • 361 Views
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Commentary

The role of MXI1 in VHL deficient tumorigenesis
Waihay J. Wong & M. Celeste Simon
Pages: 1628-1629
Published online: 01 Oct 2008
AbstractforThe role of MXI1 in VHL deficient tumorigenesis | PDF (538.7 KB)
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Research Paper

Article
A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells
Srikumar M. Raja, Robert J. Clubb, Mitra Bhattacharyya, Manjari Dimri, Hao Cheng, Wei Pan, Cesar Ortega-Cava, Alagarsamy Lakku-Reddi, Mayumi Naramura, Vimla Band & Hamid Band
Pages: 1630-1640
Published online: 01 Oct 2008
AbstractforA combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells | PDF (5.2 MB)
  • 456 Views
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Open Access
Article
A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo
Ren Xin-Yu, Liang Zhi-Yong, Shi Xiao-Hua & Liu Tong-Hua
Pages: 1641-1647
Published online: 01 Oct 2008
AbstractforA homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo | PDF (4.1 MB)
  • 171 Views
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Article
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
Margaret A. Park, Guo Zhang, Aditi Pandya Martin, Hossein Hamed, Clint Mitchell, Philip B. Hylemon, Martin Graf, Mohamed Rahmani, Kevin Ryan, Xiang Liu, Sarah Spiegel, James Norris, Paul B. Fisher, Steven Grant & Paul Dent
Pages: 1648-1662
Published online: 01 Oct 2008
AbstractforVorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation | PDF (2.9 MB)
  • 729 Views
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Article
Identification of side population cells from bladder cancer cells by DyeCycle Violet staining
Jun Jun She, Peng Ge Zhang, Zi Ming Wang, Wei Min Gan & Xiang Ming Che
Pages: 1663-1668
Published online: 01 Oct 2008
AbstractforIdentification of side population cells from bladder cancer cells by DyeCycle Violet staining | PDF (3.3 MB)
  • 572 Views
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Article
Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo
Fang Lin, Rui Wang, Jian-Jun Shen, Xi Wang, Ping Gao, Ke Dong & Hui-Zhong Zhang
Pages: 1669-1676
Published online: 01 Oct 2008
AbstractforKnockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo | PDF (1.8 MB)
  • 389 Views
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Commentary

RNA helicase and colon cancer
Jun Zhang, Hwan Ki Park, Haijing Sun & Peiwen Fei
Pages: 1677-1678
Published online: 01 Oct 2008
AbstractforRNA helicase and colon cancer | PDF (647 KB)
  • 142 Views
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Research Paper

Article
Autophagy induced by farnesyltransferase inhibitors in cancer cells
Jingxuan Pan, Bo Chen, Chun-Hui Su, Ruiying Zhao, Zhi-Xiang Xu, Lily Sun, Mong-Hong Lee & Sai-Ching Jim Yeung
Pages: 1679-1684
Published online: 01 Oct 2008
AbstractforAutophagy induced by farnesyltransferase inhibitors in cancer cells | PDF (1.4 MB)
  • 496 Views
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Article
Fluoxetine inhibits the extracellular signal regulated kinase pathway and suppresses growth of cancer cells
Andrzej Stepulak, Wojciech Rzeski, Marco Sifringer, Katja Brocke, Alexander Gratopp, Krzysztof Kupisz, Lechoslaw Turski & Chrysanthy Ikonomidou
Pages: 1685-1693
Published online: 01 Oct 2008
AbstractforFluoxetine inhibits the extracellular signal regulated kinase pathway and suppresses growth of cancer cells | PDF (1.7 MB)
  • 1116 Views
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Article
TGFβ modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells
Jimmy Y.C. Chow, Jennifer A. Cabral, Jessica Chang & John M. Carethers
Pages: 1694-1699
Published online: 01 Oct 2008
AbstractforTGFβ modulates PTEN expression independently of SMAD signaling for growth proliferation in colon cancer cells | PDF (1,002 KB)
  • 278 Views
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