Cancer Biology & Therapy, Volume 7, Issue 12 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 12 (2008)

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Editor's Corner

Editorial
Cover Caption
Page: i
Published online: 01 Dec 2008
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News

News
Johns Hopkins prostate cancer specialist William Nelson to head Institution's Cancer Center
Page: 1866
Published online: 01 Dec 2008
AbstractforJohns Hopkins prostate cancer specialist William Nelson to head Institution's Cancer Center | PDF (512.6 KB)
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Review

Review Article
Apoptosis and tumor resistance conferred by Par-4
Yanming Zhao & Vivek M. Rangnekar
Pages: 1867-1874
Published online: 01 Dec 2008
AbstractforApoptosis and tumor resistance conferred by Par-4 | PDF (1.5 MB)
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Review Article
Cancer cell killing via ROS: To increase or decrease, that is the question
Jie Wang & Jing Yi
Pages: 1875-1884
Published online: 01 Dec 2008
AbstractforCancer cell killing via ROS: To increase or decrease, that is the question | PDF (824 KB)
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Research Paper

Article
A survivin specific T-cell clone from a breast cancer patient displays universal tumor cell lysis
Rikke Bæk Sørensen, Inge Marie Svane, Per thor Straten & Mads Hald Andersen
Pages: 1885-1887
Published online: 01 Dec 2008
AbstractforA survivin specific T-cell clone from a breast cancer patient displays universal tumor cell lysis | PDF (435 KB)
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Commentary

Survivin as a universal tumor antigen for novel cancer immunotherapy: Functions of a killer clone
Nicole A. Aqui & Robert H. Vonderheide
Pages: 1888-1889
Published online: 01 Dec 2008
AbstractforSurvivin as a universal tumor antigen for novel cancer immunotherapy: Functions of a killer clone | PDF (154.8 KB)
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Research Paper

Article
Molecular expression of Gastrokine 1 in normal mucosa and in Helicobacter pylori-related preneoplastic and neoplastic gastric lesions
Gerardo Nardone, Giovanni Martin, Alba Rocco, Giovanna La Monica, Emilia Rippa, Flora Caruso & Paolo Arcari
Pages: 1890-1895
Published online: 01 Dec 2008
AbstractforMolecular expression of Gastrokine 1 in normal mucosa and in Helicobacter pylori-related preneoplastic and neoplastic gastric lesions | PDF (629.3 KB)
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Article
Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro
Jie Lin, Maode Lai, Qiong Huang, Wenjing Ruan, Yu Ma & Jing Cui
Pages: 1896-1900
Published online: 01 Dec 2008
AbstractforReactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro | PDF (502 KB)
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Article
Silencing survivin results in synergy between methylseleninic acid and paclitaxel against skov3 ovarian cancer cells
Rami G. Azrak, Cheryl L. Frank, Ali Ghadersohi & Youcef M. Rustum
Pages: 1901-1908
Published online: 01 Dec 2008
AbstractforSilencing survivin results in synergy between methylseleninic acid and paclitaxel against skov3 ovarian cancer cells | PDF (1.3 MB)
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Article
Two different HPV-11E6 fusion proteins trap p53 in the cytoplasm and induce apoptosis
Lina Sun, Ge Zhang, Ting Lei, Chen Huang, Tusheng Song & Lusheng Si
Pages: 1909-1915
Published online: 01 Dec 2008
AbstractforTwo different HPV-11E6 fusion proteins trap p53 in the cytoplasm and induce apoptosis | PDF (1.3 MB)
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Commentary

Low risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis
E. Christine Pietsch & Maureen E. Murphy
Pages: 1916-1918
Published online: 01 Dec 2008
AbstractforLow risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis | PDF (517.5 KB)
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Research Paper

Article
Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats
Andrea M Stringer, Rachel J Gibson, Richard M Logan, Joanne M Bowen, Ann SJ Yeoh & Dorothy MK Keefe
Pages: 1919-1925
Published online: 01 Dec 2008
AbstractforFaecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats | PDF (959.9 KB)
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Article
Protective role of Purα to cisplatin
Rafal Kaminski, Armine Darbinyan, Nana Merabova, Satish L. Deshmane, Martyn K. White & Kamel Khalili
Pages: 1926-1935
Published online: 01 Dec 2008
AbstractforProtective role of Purα to cisplatin | PDF (3.2 MB)
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Commentary

Could Purα be a cancer target?
Luca Esposito & Antonio Giordano
Pages: 1936-1937
Published online: 01 Dec 2008
AbstractforCould Purα be a cancer target? | PDF (229 KB)
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Research Paper

Article
Suppression of proliferation of two independent NF1 malignant peripheral nerve sheath tumor cell lines by the pan-ErbB inhibitor CI-1033
Joshua T. Dilworth, Jonathan W. Wojtkowiak, Patricia Mathieu, Michael A. Tainsky, John J. Reiners Jr, Raymond R. Mattingly & Chad N. Hancock
Pages: 1938-1946
Published online: 01 Dec 2008
AbstractforSuppression of proliferation of two independent NF1 malignant peripheral nerve sheath tumor cell lines by the pan-ErbB inhibitor CI-1033 | PDF (1 MB)
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Article
18F and 18FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation
Constadina Arvanitis, Pavan K. Bendapudi, Jeffrey R. Tseng, Sanjiv Sam Gambhir & Dean W. Felsher
Pages: 1947-1951
Published online: 01 Dec 2008
Abstractfor18F and 18FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation | PDF (1.4 MB)
  • 271 Views
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Article
Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors’ anticancer efficacy
Xuerong Wang, Natalyn Hawk, Ping Yue, John Kauh, Suresh S. Ramalingam, Haian Fu, Fadlo R. Khuri & Shi-Yong Sun
Pages: 1952-1958
Published online: 01 Dec 2008
AbstractforOvercoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors’ anticancer efficacy | PDF (1.3 MB)
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Article
Muc1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway
Deepak Raina, Rehan Ahmad, Dongshu Chen, Shailendra Kumar, Surender Kharbanda & Donald W. Kufe
Pages: 1959-1967
Published online: 01 Dec 2008
AbstractforMuc1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway | PDF (1.4 MB)
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Commentary

MUCing around with tumor suppression
Ralph R. Weichselbaum
Pages: 1968-1969
Published online: 01 Dec 2008
AbstractforMUCing around with tumor suppression | PDF (178.1 KB)
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Research Paper

Article
High expression of dopamine receptor subtype 2 in a large series of neuroendocrine tumors
Erika Grossrubatscher, Silvio Veronese, Paolo Dalino Ciaramella, Raffaele Pugliese, Marco Boniardi, Luciano De Carlis, Massimo Torre, Mario Ravini, Marcello Gambacorta & Paola Loli
Pages: 1970-1978
Published online: 01 Dec 2008
AbstractforHigh expression of dopamine receptor subtype 2 in a large series of neuroendocrine tumors | PDF (876.6 KB)
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Commentary

The potential role of D2 dopamine receptors as a target in the management of neuroendocrine tumors
Antonio Ribeiro-Oliveira Jr.Marta Korbonits & Ashley B. Grossman
Pages: 1979-1981
Published online: 01 Dec 2008
AbstractforThe potential role of D2 dopamine receptors as a target in the management of neuroendocrine tumors | PDF (258.1 KB)
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Research Paper

Article
Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD
Kerstin Grund, Rezvan Ahmadi, Fortunata Jung, Verena Funke, Georg Gdynia, Axel Benner, Jaromir Sykora, Henning Walczak, Stefan Joos, Jörg Felsberg, Guido Reifenberger, Otmar D. Wiestler, Christel Herold-Mende & Wilfried Roth
Pages: 1982-1990
Published online: 01 Dec 2008
AbstractforTroglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD | PDF (766.2 KB)
  • 235 Views
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Commentary

FLIPing the apoptosis switch on in brain tumors using Troglitazone and TRAIL
Andrew B. Hollander & Jay F. Dorsey
Pages: 1991-1993
Published online: 01 Dec 2008
AbstractforFLIPing the apoptosis switch on in brain tumors using Troglitazone and TRAIL | PDF (177.1 KB)
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Research Paper

Article
Activated STAT3 is a mediator and biomarker of VEGF endothelial activation
Shao-Hua Chen, Danielle Murphy, Wiem Lassoued, Gavin Thurston, Michael D. Feldman & William M.F. Lee
Pages: 1994-2003
Published online: 01 Dec 2008
AbstractforActivated STAT3 is a mediator and biomarker of VEGF endothelial activation | PDF (2.1 MB)
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Commentary

The current state of biomarkers to predict the response to anti-Angiogenic therapies
Phuoc T. Tran & Dean W. Felsher
Pages: 2004-2006
Published online: 01 Dec 2008
AbstractforThe current state of biomarkers to predict the response to anti-Angiogenic therapies | PDF (337.7 KB)
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Research Paper

Article
Molecular identity of a pan cancer marker, CA215
Gregory Lee, Emily Laflamme, Chin-Hsiang Chien & Hong Hoi Ting
Pages: 2007-2014
Published online: 01 Dec 2008
AbstractforMolecular identity of a pan cancer marker, CA215 | PDF (400.6 KB)
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Article
High throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers
See-Hyoung Park, Xiaobing Wang, Ruiwu Liu, Kit S. Lam & Robert H Weiss
Pages: 2015-2022
Published online: 01 Dec 2008
AbstractforHigh throughput screening of a small molecule one-bead-one-compound combinatorial library to identify attenuators of p21 as chemotherapy sensitizers | PDF (1.2 MB)
  • 582 Views
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Article
Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo
Niklas Finnberg, Chris Wambi, Jeffrey H. Ware & Ann R. Kennedy
Pages: 2023-2033
Published online: 01 Dec 2008
AbstractforGamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo | PDF (4.2 MB)
  • 459 Views
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Article
TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death
Kageaki Kuribayashi, Gabriel Krigsfeld, Wenge Wang, JIng Xu, Patrick A. Mayes, David T. Dicker, Gen Sheng Wu & Wafik S. El-Deiry
Pages: 2034-2038
Published online: 01 Dec 2008
AbstractforTNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death | PDF (1.7 MB)
  • 1096 Views
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Article
Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73
Chao Lu, Wenge Wang & Wafik S. El-Deiry
Pages: 2039-2046
Published online: 01 Dec 2008
AbstractforNon-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73 | PDF (1.9 MB)
  • 269 Views
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Article
Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis
John P. Plastaras, Jay F. Dorsey, Kristina Carroll, Seok-Hyun Kim, Morris J. Birnbaum & Wafik S. El-Deiry
Pages: 2047-2053
Published online: 01 Dec 2008
AbstractforRole of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis | PDF (2 MB)
  • 518 Views
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