Cancer Biology & Therapy, Volume 7, Issue 4 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 4 (2008)

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Editor's Corner

Editorial
Cover image
Page: i
Published online: 01 May 2008
AbstractforCover image | PDF (36.3 MB)
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Journal Club

Adenomatous Polyposis Coli mutations in colon cancer: Slipping off the brake and onto the gas pedal
Amelie Boquoi & Gregory Enders
Pages: 485-487
Published online: 01 May 2008
Abstractfor Adenomatous Polyposis Coli mutations in colon cancer: Slipping off the brake and onto the gas pedal | PDF (72.9 KB)
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Clinical Study

Article
Heterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: Results of a phase Ib/IIa study
Marta Osorio, Elías Gracia, Edmundo Rodríguez, Giselle Saurez, Maria del Carmen Arango, Elena Noris, Adriana Torriella, Alejandro Joan, Erasmo Gómez, Lorenzo Anasagasti, Jorge Luis González, María de los Angeles Melgares, Imilla Torres, Joel González, Dayamí Alonso, Enrique Rengifo, Adriana Carr, Rolando Pérez, Rolando Pérez & Luis Enrique Fernández
Pages: 488-495
Published online: 01 May 2008
AbstractforHeterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: Results of a phase Ib/IIa study | PDF (733.2 KB)
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Article
Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma
Keith T. Flaherty, Mark A. Rosen, Daniel F. Heitjan, Maryann L. Gallagher, Brian Schwartz, Mitchell D. Schnall & Peter J. O'Dwyer
Pages: 496-501
Published online: 01 May 2008
AbstractforPilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma | PDF (579.4 KB)
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Research Paper

Article
A comparative study of gene vaccines encoding different extracellular domains of the vascular endothelial growth factor receptor 2 in the mouse model of colon adenocarcinoma CT-26
Jian Dong, Jun Yang, Ming Qing Chen, Xi Cai Wang, Zhi Ping Wu, Yan Chen, Zhi Qiang Wang & Miao Li
Pages: 502-509
Published online: 01 May 2008
AbstractforA comparative study of gene vaccines encoding different extracellular domains of the vascular endothelial growth factor receptor 2 in the mouse model of colon adenocarcinoma CT-26 | PDF (1 MB)
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Article
Proteomic analysis of cervical cancer cells treated with adenovirus-mediated MDA-7
Lili Wei, Zhongtang Wang, Tao Cui, Faping Yi, Youquan Bu, Songtao Ding, Yongping Ma & Fangzhou Song
Pages: 510-516
Published online: 01 May 2008
AbstractforProteomic analysis of cervical cancer cells treated with adenovirus-mediated MDA-7 | PDF (698.8 KB)
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Article
Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: A potential therapeutic target in nasopharyngeal carcinoma
Song Zhang, Jian-Xin Yue, Ju-Hong Yang, Peng-Cheng Cai & Wei-Jia Kong
Pages: 517-522
Published online: 01 May 2008
AbstractforOverexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: A potential therapeutic target in nasopharyngeal carcinoma | PDF (1.2 MB)
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Article
Histone deacetylase (HDAC) encoding gene expression in pancreatic cancer cell lines and cell sensitivity to HDAC inhibitors
M. Ouaïssi, S. Cabral, J. Tavares, A. Cordeiro da Silva, F. Mathieu-Daude, E. Mas, JP Bernard, B. Sastre, D. Lombardo & A. Ouaissi
Pages: 523-531
Published online: 01 May 2008
AbstractforHistone deacetylase (HDAC) encoding gene expression in pancreatic cancer cell lines and cell sensitivity to HDAC inhibitors | PDF (961.7 KB)
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Article
A new rat model of human breast cancer for evaluating efficacy of new anti-cancer agents in vivo
Wieteke G.E. Direcks, Marcelle van Gelder, Adriaan A. Lammertsma & Carla Molthoff
Pages: 532-537
Published online: 01 May 2008
AbstractforA new rat model of human breast cancer for evaluating efficacy of new anti-cancer agents in vivo | PDF (795.2 KB)
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Commentary

A PET rat model for assessing the effectiveness of new chemotherapies
Paul T. Winnard Jr & Saraswati Sukumar
Pages: 538-539
Published online: 01 May 2008
AbstractforA PET rat model for assessing the effectiveness of new chemotherapies | PDF (514.9 KB)
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Research Paper

Article
Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp
Yafei Zhang, Yongquan Shi, Xiaohua Li, Rui Du, Guanhong Luo, Lin Xia, Wenqi Du, Huihong Zhai, Kaichun Wu, Daiming Fan & Bei Chen
Pages: 540-546
Published online: 01 May 2008
AbstractforProteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp | PDF (716.4 KB)
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Article
A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells
Rui Zhang, Tao Wang, Kai-Nan Li, Wei-Wei Qin, Rui Chen, Kai Wang, Lin-Tao Jia, Jing Zhao, Wei-Hong Wen, Yan-Ling Meng, Li-Bo Yao & An-Gang Yang
Pages: 547-554
Published online: 01 May 2008
AbstractforA survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells | PDF (779.8 KB)
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Commentary

Survivin: The promising target in hepatocellular carcinoma gene therapy
Jie Liu, Wenqi Du & Daiming Fan
Pages: 555-556
Published online: 01 May 2008
AbstractforSurvivin: The promising target in hepatocellular carcinoma gene therapy | PDF (443.9 KB)
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Research Paper

Article
Differential sensitivity of A549 non small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors
Maria L. Jaramillo, Myriam Banville, Catherine Collins, Beatrice Paul-Roc, Lucie Bourget & Maureen O'Connor-McCourt
Pages: 557-568
Published online: 01 May 2008
AbstractforDifferential sensitivity of A549 non small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors | PDF (948.8 KB)
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Article
Curcumin inhibits NFκB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells.
N Aravindan, Rakhesh Madhusoodhanan, S Ahmad, D Johnson & Terence S. Herman
Pages: 569-576
Published online: 01 May 2008
AbstractforCurcumin inhibits NFκB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. | PDF (589.9 KB)
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Article
Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells
Sylvia Fong, Mark Shoemaker, Jaclyn Cadaoas, Alvin Lo, Wayne Liao, Mary Tagliaferri, Isaac Cohen & Emma Shtivelman
Pages: 577-586
Published online: 01 May 2008
AbstractforMolecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells | PDF (869.9 KB)
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Article
Human chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo
Hossein Hamed, Clint Mitchell, Margaret A. Park, David Hanna, Aditi Pandya Martin, Benjamin Harrison, William Hawkins, David Curiel, Paul B. Fisher, Steven Grant, Adly Yacoub, Michael P. Hagan & Paul Dent
Pages: 587-593
Published online: 01 May 2008
AbstractforHuman chorionic gonadotropin (hCG) interacts with lovastatin and ionizing radiation to modulate prostate cancer cell viability in vivo | PDF (740.3 KB)
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Commentary

A multipronged approach to prostate cancer
Richard A. Franklin & James A. McCubrey
Pages: 594-595
Published online: 01 May 2008
AbstractforA multipronged approach to prostate cancer | PDF (436.9 KB)
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Research Paper

Article
Combination of metronomic gimatecan and CpG-oligodeoxynucleotides against an orthotopic pancreatic cancer xenograft
Giovanna Petrangolini, Monica Tortoreto, Paola Perego, Nives Carenini, Michelandrea De Cesare, Andrea Balsari, Franco Zunino & Graziella Pratesi
Pages: 596-601
Published online: 01 May 2008
AbstractforCombination of metronomic gimatecan and CpG-oligodeoxynucleotides against an orthotopic pancreatic cancer xenograft | PDF (605.2 KB)
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Commentary

Metronomic chemotherapy and tumor immunomodulation
Ralph J. Bernacki
Page: 602
Published online: 01 May 2008
AbstractforMetronomic chemotherapy and tumor immunomodulation | PDF (436 KB)
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Research Paper

Article
Proteasome inhibitor Bortezomib induces cell-cycle arrest and apoptosis in cell lines derived from Ewing’s sarcoma family of tumors and synergizes with TRAIL
Guangrong Lu, Vasu Punj & Preet M. Chaudhary
Pages: 603-608
Published online: 01 May 2008
AbstractforProteasome inhibitor Bortezomib induces cell-cycle arrest and apoptosis in cell lines derived from Ewing’s sarcoma family of tumors and synergizes with TRAIL | PDF (828.5 KB)
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Article
Somatic mutations to CSMD1 in colorectal adenocarcinomas
Christopher Farrell, Hampton Crimm, Paul Meeh, Randal Croshaw, Thomas Barbar, Jacob J. Vandersteenhoven, William Butler & Phillip Buckhaults
Pages: 609-613
Published online: 01 May 2008
AbstractforSomatic mutations to CSMD1 in colorectal adenocarcinomas | PDF (561.4 KB)
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Erratum

Correction
High-resolution analysis of genomic profiles of hepatocellular carcinoma cells with differential osteopontin expression
Bingsheng Sun, Jincai Wu, Ti Zhang & Changli Wang
Page: 614
Published online: 01 May 2008
AbstractforHigh-resolution analysis of genomic profiles of hepatocellular carcinoma cells with differential osteopontin expression | PDF (51.1 KB)
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