Cancer Biology & Therapy, Volume 7, Issue 5 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 5 (2008)

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Editor's Corner

Editorial
Cover Image
Page: i
Published online: 01 Jun 2008
AbstractforCover Image | PDF (2.9 MB)
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Journal Club

Silent no more: Expression of RNA from telomeres may regulate telomere length
Andrew R Snyder
Pages: 619-621
Published online: 01 Jun 2008
AbstractforSilent no more: Expression of RNA from telomeres may regulate telomere length | PDF (493 KB)
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Clinical Study

Article
Clinical significance of B7-H1（PD-L1）expression in human acute leukemia
Xiangli Chen, Shuhu Liu, Liancai Wang, Wang-Gang Zhang, Yuqiang Ji & Xiaorong Ma
Pages: 622-627
Published online: 01 Jun 2008
AbstractforClinical significance of B7-H1（PD-L1）expression in human acute leukemia | PDF (638.1 KB)
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Article
Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans
John P. Plastaras, Neha Vapiwala, Mona S. Ahmed, Deborah Gudonis, George J. Cerniglia, Michael D. Feldman, Ian Frank & Anjali K. Gupta
Pages: 628-635
Published online: 01 Jun 2008
AbstractforValidation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans | PDF (663.4 KB)
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Commentary

Progress towards the use of HIV proteases in cancer therapy
Eric J. Bernhard & Thomas B. Brunner
Pages: 636-637
Published online: 01 Jun 2008
AbstractforProgress towards the use of HIV proteases in cancer therapy | PDF (585.7 KB)
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Research Paper

Article
Telomere length in lymphoblast cell lines derived from clinically radiosensitive cancer patients
Carl N. Sprung, Deborah S.P. Davey, Nimali P. Withana, Luitpold V. Distel & Michael J. McKay
Pages: 638-644
Published online: 01 Jun 2008
AbstractforTelomere length in lymphoblast cell lines derived from clinically radiosensitive cancer patients | PDF (1.1 MB)
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Article
XRCC1 codon 399 mutant allele: A risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy
Rama Devi Mittal, Ranjana Singh, Parmeet Kaur Manchanda, Dinesh Ahirwar, Ruchika Gangwar, Pravin Kesarwani & Anil Mandhani
Pages: 645-650
Published online: 01 Jun 2008
AbstractforXRCC1 codon 399 mutant allele: A risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy | PDF (595.4 KB)
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Article
Inhibition of tumor growth and metastasis by ATF-Fc, an engineered antibody targeting urokinase receptor
Xian-wen Hu, Hai-feng Duan, Hai-feng Duan, Shu-yuan Pan, Yong-mei Li, Yongyi Xi, Su-Rong Zhao, Liang Yin, Jin-feng Li, Hui-Peng Chen, Chu-Tse Wu & Li-Hua Gao
Pages: 651-659
Published online: 01 Jun 2008
AbstractforInhibition of tumor growth and metastasis by ATF-Fc, an engineered antibody targeting urokinase receptor | PDF (1 MB)
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Commentary

The feasibility of uPA/uPAR-targeting strategies in cancer treatment
Shijie Sheng
Pages: 660-662
Published online: 01 Jun 2008
AbstractforThe feasibility of uPA/uPAR-targeting strategies in cancer treatment | PDF (590.1 KB)
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Research Paper

Article
PBEF1/NAmPRTase/Visfatin: A potential malignant astrocytoma/glioblastoma serum marker with prognostic value
P. Sreekanth Reddy, Srikantha Umesh, Balaram Thota, Ashwani Tandon, Paritosh Pandey, A. S. Hegde, Anandh Balasubramaniam, B. A. Chandramouli, Vani Santosh, M. R. S Rao, Paturu Kondaiah & Kumaravel Somasundaram
Pages: 663-668
Published online: 01 Jun 2008
AbstractforPBEF1/NAmPRTase/Visfatin: A potential malignant astrocytoma/glioblastoma serum marker with prognostic value | PDF (778.8 KB)
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Article
RUNX3 inhibits growth of HCC cells and HCC xenografts in mice in combination with adriamycin
Xiaohua Li, Ying Zhang, Yafei Zhang, Taidong Qiao, Kaichun Wu, Jie Ding, Jie Liu & Daiming Fan
Pages: 669-676
Published online: 01 Jun 2008
AbstractforRUNX3 inhibits growth of HCC cells and HCC xenografts in mice in combination with adriamycin | PDF (1.1 MB)
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Article
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration
Masanao Murakami, Patricio I. Meneses, Ke Lan & Erle S. Robertson
Pages: 677-688
Published online: 01 Jun 2008
AbstractforThe suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration | PDF (1.2 MB)
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Article
The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells
Yunfeng Zou, Piye Niu, Jin Yang, Jing Yuan, Tangchun Wu & Xuemi Chen
Pages: 689-696
Published online: 01 Jun 2008
AbstractforThe JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells | PDF (1 MB)
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Commentary

Role of reactive oxygen species (ROS) and JNKs in selenite-induced apoptosis in HepG2 cells
Durga P. Cherukuri & Mark A. Nelson, V
Pages: 697-698
Published online: 01 Jun 2008
AbstractforRole of reactive oxygen species (ROS) and JNKs in selenite-induced apoptosis in HepG2 cells | PDF (522.4 KB)
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Research Paper

Article
Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination
Hanna Berglind, Yudi Pawitan, Shunsuke Kato, Chikashi Ishioka & Thierry Soussi
Pages: 699-708
Published online: 01 Jun 2008
AbstractforAnalysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination | PDF (2.9 MB)
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Article
Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO
Jennifer Alabran, Adam Cheuk, Karen Liby, Michael Sporn, Javed Khan, John Letterio & Konstantin S Leskov
Pages: 709-717
Published online: 01 Jun 2008
AbstractforHuman neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO | PDF (912 KB)
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Commentary

Therapeutic potential of synthetic triterpenoids in neuroblastoma
Shi-Yong Sun
Pages: 718-720
Published online: 01 Jun 2008
AbstractforTherapeutic potential of synthetic triterpenoids in neuroblastoma | PDF (499.7 KB)
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Research Paper

Article
Chemotherapy targeting regional lymphatic tissues to treat rabbits bearing VX2 tumor in the mammary glands
Jianghao Chen, Qing Yao, Dong Li, Bin Zhang, Liwen Li & Ling Wang
Pages: 721-725
Published online: 01 Jun 2008
AbstractforChemotherapy targeting regional lymphatic tissues to treat rabbits bearing VX2 tumor in the mammary glands | PDF (578.7 KB)
  • 404 Views
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Article
Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic MABS C225 and 425
Vishal Kamat, Joshua M. Donaldson, Csaba Kari, Marlene R.D. Quadros, Peter I. Lelkes, Irwin Chaiken, Simon Cocklin, John C. Williams, Elisabeth Papazoglou & Ulrich Rodeck
Pages: 726-733
Published online: 01 Jun 2008
AbstractforEnhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic MABS C225 and 425 | PDF (1.9 MB)
  • 690 Views
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Article
Effect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice
Shi-Ming Chen, Yan Wang, Bo-Kui Xiao & Ze-Zhang Tao
Pages: 734-739
Published online: 01 Jun 2008
AbstractforEffect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice | PDF (782.9 KB)
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Commentary

Targeting the hallmarks of cancer
Aisha Siddiqa & Robert Marciniak
Pages: 740-741
Published online: 01 Jun 2008
AbstractforTargeting the hallmarks of cancer | PDF (660.1 KB)
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Research Paper

Article
Comparison of radiolabeled choline and ethanolamine as probe for cancer detection
Akiva Mintz, Limin Wang & Datta E. Ponde
Pages: 742-747
Published online: 01 Jun 2008
AbstractforComparison of radiolabeled choline and ethanolamine as probe for cancer detection | PDF (1.4 MB)
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Commentary

Plasma membrane phospholipid labeling to estimate tumor burden and kinetics
David Dingli & Val J. Lowe
Pages: 748-749
Published online: 01 Jun 2008
AbstractforPlasma membrane phospholipid labeling to estimate tumor burden and kinetics | PDF (476.9 KB)
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Research Paper

Article
Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice
Ke Guo, Jie Li, Jing Ping Tang, Cheng Peow Bobby Tan, Haihe Wang, Haihe Wang & Qi Zeng
Pages: 750-757
Published online: 01 Jun 2008
AbstractforMonoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice | PDF (1.1 MB)
  • 772 Views
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Article
Functional significance of VEGF-a in human ovarian carcinoma: Role in vasculogenic mimicry
Jun-yan Wang, Tao Sun, Xiu-lan Zhao, Shi-wu Zhang, Qiang Gu, Xing-hui Wang, Nan Zhao, Shuo Qie & Bao-cun Sun
Pages: 758-766
Published online: 01 Jun 2008
AbstractforFunctional significance of VEGF-a in human ovarian carcinoma: Role in vasculogenic mimicry | PDF (1.1 MB)
  • 759 Views
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Article
Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol
Matthew J. Sikora, Joshua A. Bauer, ,Monique Verhaegen, Thomas J. Belbin, Michael B. Prystowsky, Joseph C. Taylor, J. Chad Brenner, Shaomeng Wang, Maria S. Soengas, Carol R. Bradford & Thomas E. Carey
Pages: 767-776
Published online: 01 Jun 2008
AbstractforAnti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol | PDF (1.3 MB)
  • 218 Views
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Article
Nuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis
Yi-Ju Chen, Chun-Ying Wu, Chia-Che Chang, Chieh-Ju Ma, Mu-Chun Li & Chuan-Mu Chen
Pages: 777-782
Published online: 01 Jun 2008
AbstractforNuclear Krüppel-like factor 4 expression is associated with human skin squamous cell carcinoma progression and metastasis | PDF (867.9 KB)
  • 447 Views
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Commentary

Bad things happen in the basal layer: KLF4 and squamous cell carcinoma
Wen Jiang, Susan M. Lobo-Ruppert & J. Michael Ruppert
Pages: 783-785
Published online: 01 Jun 2008
AbstractforBad things happen in the basal layer: KLF4 and squamous cell carcinoma | PDF (531.1 KB)
  • 188 Views
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Research Paper

Article
Characterization of infectivity of knob-modified adenoviral vectors in glioma
C.P.L. Paul, M. Everts, P. Dent, P.B. Fisher, I.V. Ulasov, M.S. Lesniak, M.A. Stoff-Khalili, J.C. Roth, J.N. Glasgow, M.A. Preuss, C.M.F. Dirven, M.L.M. Lamfers, Gene P. Siegal, Z.B. Zhu & D.T. Curiel
Pages: 786-793
Published online: 01 Jun 2008
AbstractforCharacterization of infectivity of knob-modified adenoviral vectors in glioma | PDF (1.6 MB)
  • 285 Views
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Commentary

Interspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas
Candelaria Gomez-Manzano, Marta Alonso, Hong Jiang & Juan Fueyo
Pages: 794-796
Published online: 01 Jun 2008
AbstractforInterspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas | PDF (633.8 KB)
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